PPFMs (pink-pigmented facultative methylotrophs - especially Methylobacterium spp.) are bacterial symbionts of plants, shown previously to participate in plant metabolism. One on-going theme of research in our lab is the development of methods for exploiting the relationship between these bacteria and their host plants for plant improvement. We report here on our efforts to alter the nutritional quality of crop plants by replacing their native PPFMs with selected mutant strains of the bacteria. Using a combination of selective media and auxotrophic mutants of E.coli and Arthrobacter sp., we isolated methionine- and vitamin B12-overproducing PPFM mutants and have colonized plants with them. Our hope is that the PPFM overproducers will feed the host, resulting in an increase of B12 or methionine in host tissues. Analysis of these plants is in progress. The significance of this strategy for improvement of crop plants is discussed.

Key words: Methylobacterium, mutant selection, nutrition, PPFM, symbiosis