Adenophora is a morphologically diverse genus of approximately 50 species of eastern Asia; the greatest diversity of Adenophora species is found in China. Several taxonomic treatments have proposed alternative subgeneric divisions within the genus. In order to resolve the taxonomic ambiguities of Adenophora, a molecular phylogenetic analysis was carried out using sequences of the internal transcribed spacers (ITS) of nuclear ribosomal DNA. Twenty-four species of Adenophora were sampled, representing all of the previously recognized sections and subsections. Three species of Campanula were used as outgroups. Among the Adenophora species, the length of combined ITS-1 and ITS-2 sequences ranged from 537 to 542 nucleotides; 5.7% of nucleotide substitutions was phylogenetically informative. Parsimony analyses suggested that none of the four sections recognized by Federov (1957) and Tu (1993) is monophyletic. Hong(1983)'s two-section classification, however, is generally concordant with the ITS phylogeny except that A. triphylla of sect. Adenophora is nested within sect. Microdiscus and A. trachelioides of sect. Microdiscus forms a clade with species in sect. Adenophora. Pairwise comparisons at unambiguously aligned sites showed that the sequence divergence was relatively low among Adenophora species with the values ranging from 0.0 to 3.9%. In contrast, high sequence divergence was found among Adenophora and Campanula species with the values ranging from 17.8 to 19.2%. These findings suggest a relatively recent origin of Adenophora coupled with rapid morphological diversification within the genus.

Key words: Adenophora, Campanulaceae, classification, ITS, phylogeny