A. True/False; multiple choice questions:

1. a.
2. d.
3. a.
4. e.
5. c.
6. b .
7. b.
8. c.
9. c.
10. b.
11. b.
12. d.
13. a.
14. d.
15. b.
16. a.
17. b.
18. d.
19. e.
20. d.

B. Match and Identify:

(See text and notes)

C. Short Problems:

1a. Yes, Mrs. Denton is a reciprocal translocation heterozygote.
1b. A normal 6 and a translocation chromosome were donated by the mother to the egg.
1c. The child is trisomic and monosomic for regions of chromosomes 6 and 12.
1d. Although they may have similarly affected fetuses, they can also potentially have phenotypically normal children, some of which might be translocation heterozygotes like Mrs. Denton.
1e. See above; the karyotype of the fetus can be monitored by amniocentesis or CVS.

2a. False.
2b. His-Leu-Trp
2c. to kill off donor cells.
2d. the Trp marker will enter the cell in lowest frequency and only a fraction of the Trp+ cells will also carry the Leu marker, since that requires recombination to occur to the outside of both these loci.