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Faculty and Research

Faculty Member

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Ari Berkowitz

Chuanbin Mao

George Lynn Cross Research Professor, Chemistry & Biochemistry Stephenson Life Sciences Research Center 3310 405-325-4385 Ph.D., Materials Chemistry- Northeastern University, China, 1997

RESEARCH:

My research is focused on the use of nanotechnology in studying cell and neurobiology and developing biomedical technologies. Specifically, my research group is actively employing genetically engineered phage to understand cell-matrix interactions and develop nanomedicine. Phage can be genetically engineered to display foreign peptides site-specifically on the surface, enabling us to tune their surface chemistries to control their self-assembly behavior, recognition against mammalian cells and interaction with materials. We are interested in exploring the use of phage display techniques for cancer treatment, stem cell therapy, and nano/bio-materials synthesis/assembly. In particular, we will integrate phage display techniques and nanotechnology to study neurobiology and neuroregeneration.

Selected Publications:

Cao, B., Xu, H., and Mao, C. B. (2011) Controlled self-assembly of rod-like bacterial pili particles into ordered lattices. Angewandte Chemie International Edition 50: 6264-6268.

Zhu, H., Cao, B., Zhen, Z., Laxmi, A., Li, D., Liu, S., and Mao, C. B. (2011) Controlled growth and differentiation of mesenchymal stem cells on grooved films assembled from monodisperse biological nanofibers with genetically tunable surface chemistries. Biomaterials 32: 4744-4752 (doi: 10.1016/j.biomaterials.2011.03.030).

Sreeram, K. J., Narayan, S., Abbineni, G., Hayhurst, A., and Mao, C. B. (2010) Architectonics of phage-liposome nanowebs as optimized photosensitizer vehicles for photodynamic cancer therapy. Molecular Cancer Therapeutics 9: 2524-2535. (Selected as a Cover Story)

Abbineni, G., Modali, S., Safiejko-Mroczka, B., Petrenko, V. A., and Mao, C. B. (2010) Evolutionary selection of new breast cancer cell-targeting peptides and phages with the cell-targeting peptides fully displayed on the major coat and their effects on actin dynamics during cell internalization. Molecular Pharmaceutics 7: 1629–1642.

He, T., Abbineni, G., Cao, B., and Mao, C. B. (2010) Nanofibrous bio-inorganic hybrid structures formed through self-assembly and oriented mineralization of genetically engineered phage nanofibers. Small 6: 2230-2235.

Abbineni, G., Safiejko-Mroczka, B., and Mao, C. B. (2010) Development of an optimized protocol for studying the interaction of filamentous bacteriophage with mammalian cells by fluorescence microscopy. Microscopy Research & Technique 73: 548-554.

Sun, P., Zhang, H., Liu, C., Fang, J., Wang, M., Chen, J., Zhang, J., Mao, C. B. , and Xu, S. K. (2010) Preparation and characterization of Fe3O4/CdTe magnetic/fluorescent nanocomposites and their applications in immuno-labeling and fluorescent imaging of cancer cells. Langmuir 26: 1278-1284.

Mao, C. B., Liu, A., and Cao, B. (2009) Virus-based chemical and biological sensing. Angewandte Chemie International Edition 48: 6790-6810.

Wang, M., Mi, C., Wang, W., Liu, C., Wu, Y., Xu, Z., Mao, C. B., and Xu, S. K. (2009) Immunolabelling and NIR-excited fluorescent imaging of HeLa cells by using NaYF4:Yb,Er upconversion nanoparticles. ACS Nano 3: 1580-1586.

Cao, B., and Mao, C. B. (2009) Identification of microtubule-binding domains on microtubule-associated proteins by major coat phage display technique. Biomacromolecules 10: 555-564.