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Faculty and Research

Faculty Member

Ari Berkowitz

Chuanbin Mao

George Lynn Cross Research Professor, Chemistry & Biochemistry Stephenson Life Sciences Research Center 3310 405-325-4385 Ph.D., Materials Chemistry- Northeastern University, China, 1997


My research is focused on the use of nanotechnology in studying cell and neurobiology and developing biomedical technologies. Specifically, my research group is actively employing genetically engineered phage to understand cell-matrix interactions and develop nanomedicine. Phage can be genetically engineered to display foreign peptides site-specifically on the surface, enabling us to tune their surface chemistries to control their self-assembly behavior, recognition against mammalian cells and interaction with materials. We are interested in exploring the use of phage display techniques for cancer treatment, stem cell therapy, and nano/bio-materials synthesis/assembly. In particular, we will integrate phage display techniques and nanotechnology to study neurobiology and neuroregeneration.

Selected Publications:

Cao, B., Xu, H., and Mao, C. B. (2011) Controlled self-assembly of rod-like bacterial pili particles into ordered lattices. Angewandte Chemie International Edition 50: 6264-6268.

Zhu, H., Cao, B., Zhen, Z., Laxmi, A., Li, D., Liu, S., and Mao, C. B. (2011) Controlled growth and differentiation of mesenchymal stem cells on grooved films assembled from monodisperse biological nanofibers with genetically tunable surface chemistries. Biomaterials 32: 4744-4752 (doi: 10.1016/j.biomaterials.2011.03.030).

Sreeram, K. J., Narayan, S., Abbineni, G., Hayhurst, A., and Mao, C. B. (2010) Architectonics of phage-liposome nanowebs as optimized photosensitizer vehicles for photodynamic cancer therapy. Molecular Cancer Therapeutics 9: 2524-2535. (Selected as a Cover Story)

Abbineni, G., Modali, S., Safiejko-Mroczka, B., Petrenko, V. A., and Mao, C. B. (2010) Evolutionary selection of new breast cancer cell-targeting peptides and phages with the cell-targeting peptides fully displayed on the major coat and their effects on actin dynamics during cell internalization. Molecular Pharmaceutics 7: 1629–1642.

He, T., Abbineni, G., Cao, B., and Mao, C. B. (2010) Nanofibrous bio-inorganic hybrid structures formed through self-assembly and oriented mineralization of genetically engineered phage nanofibers. Small 6: 2230-2235.

Abbineni, G., Safiejko-Mroczka, B., and Mao, C. B. (2010) Development of an optimized protocol for studying the interaction of filamentous bacteriophage with mammalian cells by fluorescence microscopy. Microscopy Research & Technique 73: 548-554.

Sun, P., Zhang, H., Liu, C., Fang, J., Wang, M., Chen, J., Zhang, J., Mao, C. B. , and Xu, S. K. (2010) Preparation and characterization of Fe3O4/CdTe magnetic/fluorescent nanocomposites and their applications in immuno-labeling and fluorescent imaging of cancer cells. Langmuir 26: 1278-1284.

Mao, C. B., Liu, A., and Cao, B. (2009) Virus-based chemical and biological sensing. Angewandte Chemie International Edition 48: 6790-6810.

Wang, M., Mi, C., Wang, W., Liu, C., Wu, Y., Xu, Z., Mao, C. B., and Xu, S. K. (2009) Immunolabelling and NIR-excited fluorescent imaging of HeLa cells by using NaYF4:Yb,Er upconversion nanoparticles. ACS Nano 3: 1580-1586.

Cao, B., and Mao, C. B. (2009) Identification of microtubule-binding domains on microtubule-associated proteins by major coat phage display technique. Biomacromolecules 10: 555-564.