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Publications & Presentations

Peer-Reviewed Journal Publications

36. Jett, S.V., Hudson, L.T., Bohnstedt, B.N., Mir, A., Burkhart, H.M, Wu, Y., and Lee, C.-H., “Integration of polarized spatial frequency domain imaging (pSFDI) with a biaxial mechanical testing system for quantification of load-dependent collagen architecture in soft collagenous tissues,” Acta Biomaterialia (available online on November 14th 2019DOI: 10.1016/j.actbio.2019.11.028.

35. Duginski, G.A., Ross, C.J., Laurence, D.W., Johns, C.H., and Lee, C.-H., “An investigation of the effect of freezing storage on the biaxial mechanical properties of excised porcine tricuspid valve anterior leaflets,” Journal of the Mechanical Behavior of Biomedical Materials, 101: 103438, 2020.

34. Kramer, K.E., Ross, C.J., Laurence, D.W., Babu, A.R., Wu, Y., Towner, R.A., Mir, A., Burkhart, H.M., Holzapfel, G.A., and Lee, C.-H., “An investigation of layer-specific tissue biomechanics of porcine atrioventricular valve anterior leaflets,” Acta Biomaterialia, 96: 368-384, 2019.
Journal Website: https://www.sciencedirect.com/science/article/pii/S1742706119304714?via%3Dihub

33. Ross, C.J., Laurence, D.W., Richardson, J., Babu, A.R., Evans, L.E., Beyer, E.G., Childers, R.C., Wu, Y., Towner, R.A., Fung, K.-M., Mir, A., Burkhart, H.M., Holzapfel, G.A., and Lee, C.-H., “An investigation of the glycosaminoglycan contribution to biaxial mechanical behaviors of porcine atrioventricular heart valve leaflets,” Journal of the Royal Society Interface, 16(156), 20190069, 2019.

32. Lee, C.-H., Laurence, D.W., Ross, C.J., Kramer, K.E., Babu, A.R., Johnson, E.L., Hsu, M.-C., Aggarwal, A., Mir, A., Burkhart, H.M., Towner, R.A., Baumwart, B., and Wu, Y., “Mechanics of the tricuspid valve-From clinical diagnosis/treatment, in-vivo and in-vitro investigations, to patient-specific biomechanical modeling,” Bioengineering, 6(2), 47 (40 pages), 2019.

31. Wang, J., Luo, J., Li, Kunkel, R.P., Saha, M., Bohnstedt, B.N., Lee, C.-H., and Liu, Y., “Development of shape memory polymer nanocomposite foam for treatment of intracranial aneurysms,” Materials Letters, 250, 38-41, 2019.

30. Laurence, D.W., Ross, C.J., Jett, S.V., Johns, C.H., Echols, A.L., Baumwart, R., Towner, R.A., Liao, J., Bajona, P., Wu, Y., and Lee, C.-H., “Regional biaxial mechanical data of the mitral and tricuspid valve anterior leaflets,” Data in Brief, 24, 103961, 2019

29. Sacks, M.S., Drach, A., Lee, C.-H., Khalighi, A., Rego, B., Zhang, W., Ayoub, S., Yoganathan, A.P., Gorman, R.C., and Gorman, J.H., III, “On the simulation of mitral valve function in health, disease, and treatment,” Journal of Biomechanical Engineering, 141(7), 070804 (22 pages), 2019.

28. Wang, J., Kunkel, R.P., Luo, J., Li, Y., Liu, H., Bohnstedt, B.N., Liu, Y., and Lee, C.-H., “Shape memory polyurethane with porous architectures for potential applications in intracranial aneurysm treatment,” Polymers, 11(4), 631 (14 pages), 2019.

27. Laurence, D.W., Ross, C.J., Jett, S.V., Johns, C.H., Echols, A.L., Baumwart, R., Towner, R.A., Liao, J., Bajona, P., Wu, Y. & Lee, C.-H., “An investigation of regional variations in the biaxial mechanical properties and stress relaxation behaviors of porcine atrioventricular heart valve leaflets,” Journal of Biomechanics, 83: 16-27, 2019.

26. Ross, C.J., Laurence, D.W., Wu, Y., and Lee, C.-H., “Biaxial mechanical characterization of atrioventricular heart valves,” Journal of Visualized Experiments, 146: e59170, 2019.

25. Kunkel, R.P., Laurence, D.W., Wang, J., Robinson, D.O., Scherrer, J.H., Wu, Y., Bohnstedt, B.N., Chien, A., Liu, Y., and Lee, C.-H., “Synthesis and characterization of bio-compatible shape memory polymers with potential applications to endovascular embolization of intracranial aneurysms,” Journal of the Mechanical Behavior of Biomedical Materials, 88: 422-430, 2018. (This is an openly available post print for the article at: https://doi.org/10.1016/j.jmbbm.2018.08.037. This post print is available with a CC BY-NC-ND licensePost-Print)

24. Jett, S.J., Laurence, D.W., Kunkel, R.P., Babu, A.R., Kramer, K.E., Baumwart, R., Towner, R.A., Wu, Y., and Lee, C.-H., “An investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valves,” Journal of the Mechanical Behavior of Biomedical Materials, 87: 155-171, 2018. (This is an openly available post print for the article at: https://doi.org/10.1016/j.jmbbm.2018.07.024. This post print is available with a CC BY-NC-ND licensePost-Print)

23. Jett, S.J., Laurence, D.W., Kunkel, R.P., Babu, A.R., Kramer, K.E., Baumwart, R., Towner, R.A., Wu, Y., and Lee, C.-H., “Biaxial mechanical data of porcine atrioventricular valve leaflets,” Data in Brief, 21:358-363, 2018.

22. Kamensky, D., Xu, F., Lee, C.-H., Yan, J., Bazilevs, Y., and Hsu, M.-C. “A new contact formulation based on a volumetric potential: Application to isogeometric simulations of atrioventricular valves,” Computer Methods in Applied Mechanics and Engineering, 330(1): 522-546, 2018.

21. Chen, J., Zhou, B., Qiu, S., Ma, S., Lee, C.-H., Aggarwal, A., Zeng, J., Gao, M., Feng, Y., Li, D., and Shan, H., “Evaluation of the laser-induced thermotherapy (LITT) treatment effect of breast cancer based on tissue viscoelastic properties.” Journal of Engineering and Science in Medical Diagnostics and Therapy, 1(4): 041009, 2018.

20. Ayoub, S., Lee, C. -H., Driesbaugh, K.H., Anselmo, W., Hughes, C.T., Ferrari, G., Gorman, R.C., Gorman, J.H., III, and Sacks, M.S., “Regulation of valve interstitial cell homeostasis by mechanical deformation: Implications for heart valve disease and surgical repair,” Journal of Royal Society – Interface, 14(135): 20170580, 2017.

19. Wang, J., Chowdhury, S., Wu, D., Bohnstedt, B.N., Liu, Y., and Lee, C.-H. “Carbon nanotube enhanced shape memory polymer nanocomposites for development of biomedical devices,” Journal of Nanomedical Research, 6(1): 00141, 2017.

18. Lee, C.-H., Zhang, W., Feaver, K., Gorman, R.C., Gorman, III, J.H., and Sacks, M.S., “On the in vivo function of the mitral heart valve leaflet: insight into tissue-interstitial cell biomechanical coupling,” Biomechanical Modeling and Mechanobiology, 16(5): 00141, 2017.

16. Feng, Y., Qiu, S., Xia, X., Ji, S., and Lee, C.-H., “A computational study of invariant I5 in a nearly incompressible transversely isotropic model for white matter,” Journal of Biomechanics, 57: 146-151, 2017.

15. Rego, B.V., Wells, S.M., Lee, C.-H., and Sacks, M. ., “Mitral valve remodeling during pregnancy: insights into cell-mediated recovery of tissue homeostasis,” Journal of the Royal Society Interface, 13(125): 20160709, 2016.

14. Lee, C.-H., Rabbah, J.P., Yoganathan, A.P., Gorman, R.C., Gorman, III, J.H., and Sacks, M.S., “On the effect of leaflet microstructure and constitutive model on the closing behavior of the mitral valve.” Biomechanical Modeling and Mechanobiology, 14(6): 1281-1302, 2015.

13. Lee, C.-H., Zhang, W., Carruthers, C.A., Sacks, J.I., and Sacks, M.S., “On the presence of affine fiber and fibril kinematics in the mitral valve anterior leaflet under simulated physiological loading.” Biophysical Journal, 108(8): 2074-2087, 2015.

12. Lee, C.-H., Carruthers, C.A., Ayoub, S., Gorman, R.C., Gorman, III, J.H., and Sacks, M.S., “Quantification and simulation of the layer-specific mitral valve interstitial cell deformations under physiological loading.” Journal of Theoretical Biology, 373: 26-39, 2015.

11. Khalighi, A.H., Drach, A., ter Huurne, F.M., Lee, C.-H., Bloodworth, C.H., Pierce, E.L., Jensen, M.O., Yoganathan, A.P., and Sacks, M.S., “A comprehensive framework for the characterization of the complete mitral valve geometry for the development of a population-averaged model.” Lecture Notes in Computer Science, 9126: 164-171, 2015.

10. Zhang, W., Feng, Y., Lee, C.-H., Billiar, K.L., and Sacks, M.S., “A generalized method for the analysis of planar biaxial mechanical data using tethered testing configurations.” Journal of Biomechanical Engineering, 137: 064501-1-13, 2015.

9. Drach, A., Khalighi, A.H., ter Huurne, F.M., Lee, C.-H., Bloodworth, C.H., Pierce, E.L., Jensen, M.O., Yoganathan, A.P., and Sacks, M.S., “Population-averaged geometric model of mitral valve from patient-specific imaging data.” Journal of Medical Devices, 9(3): 030952-1-3, 2015.

8. Chi, S.-W., Lee, C.-H., Guan, P.-C., and Chen, J.S., “A level set enhanced natural kernel contact algorithm for impact and penetration modeling.” International Journal for Numerical Methods in Engineering, 102: 839-866, 2015.

7. Lee, C.-H., Amini, R., Gorman, R.C., Gorman, III, J.H., and Sacks, M.S., “An inverse modeling approach for stress estimation in mitral valve anterior leaflet valvuloplasty for in-vivo valvular biomaterial assessment.” Journal of Biomechanics, 47(9): 2055-2063, 2014.

6. Lee, C.-H., Oomen, P.J.A., Rabbah, J.P., Yoganathan, A.P., Gorman, R.C., Gorman, III, J.H.,  Amini, R., and Sacks, M.S., “A high-fidelity and micro-anatomically accurate 3D finite element model for simulations of functional mitral valve.” Lecture Notes in Computer Science,7945: 416-424, 2013.

5. Aggarwal, A., Aguilar, V.S., Lee, C.-H., Ferrari, G., Gorman, III, J.H., Gorman, R.C., and Sacks, M.S., “Patient-specific modeling of heart valves: from images to simulation.” Lecture Notes in Computer Science, 7945: 141-149, 2013.

4. Lee, C.-H., and Chen, J.S., “Proper orthogonal decomposition-based model order reduction via radial basis functions for molecular dynamics systems.” International Journal for Numerical Methods in Engineering, 96: 599-627, 2013.

3.  Lee, C.-H., and Chen, J.S., “RBF-POD reduced-order modeling of DNA molecules under stretching and bending.” Interaction. Multiscale Mechanics, 6(4): 395-409, 2013.

2. Teng, H., Lee, C.-H., and Chen, J.S., “On the continuum formulation for modeling DNA loop formation.” Interaction. Multiscale Mechanics, 4: 219-237, 2012.

1. Leu, L.J., and Lee, C.-H., “Optimal design system using finite element package as the analysis engine.”  Advances in Structural Engineering, 10: 713-723, 2007.

    

Book Chapters

6. Khang, A., Buchanan, R.M., Ayoub, S., Rego, R.V., Lee, C. H., Ferrari, G., Anseth, K.S., and Sacks, M.S., “Mechanobiology of the heart valve interstitial cell: Simulation, experiment, and discovery.” Mechanobiology in Health and Disease, Springer, pgs. 249-283, 2018.

5. Rego, B.V., Wells, S.M., Lee, C.-H., and Sacks, M.S., “Remodelling potential of the mitral heart valve leaflet.” Advances in Heart Valve Biomechanics, Springer, pgs. 181-206, 2018.

4. Khang, A., Buchanan, R.M., Ayoub, S., Rego, R.V., Lee, C.-H., and Sacks, M.S., “Biological mechanics of the heart valve interstitial cells.” Advances in Heart Valve Biomechanics, Springer, pgs. 3-36, 2018.

3. Lee, C. H., and Sacks, M.S., “Fiber to organs: how collagen fiber properties modulate the closing behavior of the mitral valve.” Structure-Based Mechanics of Tissues and Organs, Springer, pgs. 365-381, 2016.

2. Lee, C. H., Amini, R., Sakamoto, Y., Carruthers, C.A., Gorman, R.C., Gorman, III, J. H., and  Sacks, M.S., “Mitral valve: a computational framework.” Multiscale Modeling in Biomechanics and Mechanobiology, Springer, pgs. 223-256, 2015.

1. Chen, J. S., Lee, C. H., Teng, H., and Wang, H., “Atomistic to continuum modeling of DNA molecules.” Advances in Soft Matter Mechanics, Springer, pgs. 1-53, 2012.

    

Technical Reports

3. Lee, C. H., “A novel high-fidelity micro-anatomically accurate model for the improved design of mitral valve repair and remodeling,” Scientific Report, SWA Summer 2013 Postdoctoral Fellowship (14POST18160013), the American Heart Association, 2015.

2. Chi, S. W., Lee, C. H., Chen, J. S., Roth, M. J., and Slawson, T. R., “User’s Manual for Nonlinear Meshfree Analysis Program (NMAP) Version 1.0,” Technical Report, U.S. Army Corps of Engineer Research and Development Center (ERDC/GSL TR-12-36), 2012

1. Chen, J. S., Chi, S. W., Lee, C. H., Lin, S. P., Marodon, C., and Roth, M. J., “A Multi-scale Meshfree Approach for Modeling Fragment Penetration into Ultra High Strength Concrete,” Technical Report, U.S. Army Corps of Engineer Research and Development Center (ERDC/GSL TR-11-35), 2011

    

Presentations/Abstracts in Conferences and Proceedinds

95. Hudson, L., Jett, S., Kramer, K., Mir, A., Burkhart. H.M., and Lee, C.-H., “Dynamic microstructural and mechanical examination of tricuspid valve leaflet tissues,” 2019 BMES Annual Meeting, Philadelphia, October 16-19, 2019.

94. Laurence, D., Johnson, E., Hsu, M.-C., Mir, A., Burkhart, H.A., and Lee, C.-H., “Finite element-based computational studies of the healthy and diseased tricuspid valve function,” 2019 BMES Annual Meeting, Philadelphia, October 16-19, 2019.

93. Ross, C., Mir, A., Burkhart, H.M., Wu, Y., and Lee, C.-H., “Contributions of porcine heart valve leaflet microstructure to stress-stretch behaviors of chordae tendineae groups,” 2019 BMES Annual Meeting, Philadelphia, October 16-19, 2019.

92. Kunkel, R.P., Wang, J., Luo, J., Bohnstedt, B.N., Liu, Y., and Lee, C.-H., “Synthesis and characterization of porous shape memory polymer materials for use in the design of implantable medical devices.” Summer Biomechanics, Bioengineering, Biotransport Conference (SB3C2019), Seven Springs, PA, June 25-28, 2019.

91. Ross, C.J., Laurence, D.W., Zhao, Y.D., Hsu, M.-C., Baumwart, R., Wu, Y., and Lee, C.-H., “Investigations of the chordae tendineae’s mechanical properties of porcine atrioventricular heart valves.” Summer Biomechanics, Bioengineering, Biotransport Conference (SB3C2019), Seven Springs, PA, June 25-28, 2019.

90. Johns, C.H., Kramer, K.E., Anju, B.R., and Lee, C.-H., “An investigation of layer-specific tissue biomechanics of porcine atrioventricular valve anterior leaflets.” Summer Biomechanics, Bioengineering, Biotransport Conference (SB3C2019), Seven Springs, PA, June 25-28, 2019.

89. Laurence, D.W., Johnson, E.L., Hsu, M.-C., Mir, A., Burkhart, H.M., Wu, Y., and Lee, C.-H., “Finite element simulation framework for investigating pathological effects on organ-level tricuspid valve biomechanical function.” Summer Biomechanics, Bioengineering, Biotransport Conference (SB3C2019), Seven Springs, PA, June 25-28, 2019.

88. Jett, S.V., Schuermann, Z., Mir, A., Burkhart, H.M., and Lee, C.-H., “An integrated opto-mechanical system for quantification of dynamic microstructure and mechanics of heart valve tissues.” Summer Biomechanics, Bioengineering, Biotransport Conference (SB3C2019), Seven Springs, PA, June 25-28, 2019.

87. Lee, C.-H., Ross, C.J., Laurence, D.W., Evans, L.E., Richardson, J., Babu, A.R., Beyer, E.G., Wu, Y., Holzapfel, G.A., Mir, A., Burkhart, H.M., “Role of glycosaminoglycans in biaxial mechanical behaviors of porcine atrioventricular heart valve leaflets.” Summer Biomechanics, Bioengineering, Biotransport Conference (SB3C2019), Seven Springs, PA, June 25-28, 2019.

86. Ayoub, S., Graves, J., Lee, C.-H., and Sacks, M.S., “A physiologically-driven biaxial bioreactor system to investigate valve interstitial cell phenotypic state after surgical repair.” Summer Biomechanics, Bioengineering, Biotransport Conference (SB3C2019), Seven Springs, PA, June 25-28, 2019.

85. Laurence, D.W., Johnson, E.L., Hsu, M.-C., Mir, A., Burkhart, H.M., Wu, Y., and Lee, C.-H., “Finite element biomechanical investigations of pathological effects on organ-level tricuspid valve function.” 6th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2019), Sendai, Japan, June 10-12, 2019.

84. Lee, C.-H., “My journey to brain aneurysm research.” Workshop on Meshfree Method and Advances in Computational Mechanics, Pleasanton, CA, March 10-12, 2019.

83. He, Q., Chen, J.S., and Lee, C.-H., “Physics-informed data-driven meshfree modelling for biomaterials.” Workshop on Meshfree Method and Advances in Computational Mechanics, Pleasanton, CA, March 10-12, 2019.

82. Laurence, D., Johnson, E., Hsu, M. C., Lee, C. H., “Development of a finite element model for quantifying the tricuspid valve pathological effect on valve function.” OU Gallogly College of Engineering Graduate Student Poster Fair, Norman, OK, November 9, 20181.

81. Kunkel, R., Laurence, D., Robinson, D., Scherrer, J., Chien, A., Bohnstedt, B.N., Wu, Y., Liu, Y., and Lee, C. H., “Particle image velocimetry-based validation of a CFD model for the treatment of intracranial aneurysms using a shape memory polymer embolization device.” 13th World Congress on Computational Mechanical (WCCM XIII), New York, NY, July 22-27, 2018.

80. Laurence, D., Wu, Y., and Lee, C. H., “Development of a multiscale computational modeling framework for the tricuspid valve – linking valvular interstitial cell mechanobiology with organ-level function.” 13th World Congress on Computational Mechanical (WCCM XIII), New York, NY, July 22-27, 2018.

79. Babu, A.R., Kramer, K., Laurence, D., Wu, Y., and Lee, C. H., “Layer-specific mechanical responses and morphological structure of atrioventricular valve leaflets.” 8th World Congress of Biomechanics, Dublin, Ireland, July 8-12, 2018.

78. Kramer, K., Babu, A., Hsu, M. C., Aggarwal, A., Wu, Y., and Lee, C. H., “A layer-specific constitutive model for atrioventricular valve leaflets.” Engineering Mechanics Institute Conference 2018, Boston, MA, May 29-June 1, 2018.

77. Laurence, D. W., Wu, Y., and Lee, C. H., “Development of a multiscale computational model for the tricuspid valve – linking valvular interstitial cell mechanobiology with organ-level function.” Engineering Mechanics Institute Conference 2018, Boston, MA, May 29-June 1, 2018.

76. Jett, S., Laurence, D. W., Kramer, K., Babu, A., Wu, Y., and Lee, C. H., “Biaxial mechanical testing and constitutive model development of atrioventricular valve leaflets.” Engineering Mechanics Institute Conference 2018, Boston, MA, May 29-June 1, 2018.

75. Kunkel, R. P., Robinson, D., Laurence, D. W., Scherrer, J., Wang, J., Bohnstedt, B. N., Liu, Y., and Lee, C. H., “Synthesis and characterization of aliphatic urethane shape memory polymers for endovascular embolization of intracranial aneurysms.” Engineering Mechanics Institute Conference 2018, Boston, MA, May 29-June 1, 2018.

74. Jett, S., Laurence, D. W., Ross, C., Richardson, J., Johns, C., Echols, A., Bodlak, R., and Lee, C. H., “A study on the spatial variance in heart valve mechanics.” The 2nd Curiosity to Creativity Spring Symposium, The University of Oklahoma, Norman, OK, April 25, 2018.

73. Kramer, K., Babu, A., Laurence, D. W., Johns, C., Wu, Y., and Lee, C. H., “Layer-specific mechanical responses and morphological structure of atrioventricular valve leaflets.” The 2nd Curiosity to Creativity (C2C) Spring Symposium, The University of Oklahoma, Norman, OK, April 25, 2018.

72. Kunkel, R. P., Liu, Y., Bohnstedt, B. N., Wang, J., Robinson, D., Laurence, D. W., Scherrer, J., and Lee, C. H., “Synthesis and characterization of aliphatic urethane shape memory polymers for treatment of intracranial aneurysms.” The 2nd Curiosity to Creativity Spring (C2C) Symposium, The University of Oklahoma, Norman, OK, April 25, 2018.

71. Laurence, D. W., Wu, Y., and Lee, C. H., “Development of a multiscale computational modeling framework for the tricuspid valve.” The 2nd Curiosity to Creativity (C2C) Spring Symposium, The University of Oklahoma, Norman, OK, April 25, 2018.

70. Richardson, J., and Lee, C. H., “The essential role of glycosaminoglycans in the biomechanics of heart valve leaflets.” The 2nd Curiosity to Creativity (C2C) Spring Symposium, The University of Oklahoma, Norman, OK, April 25, 2018.

69. Ross, C., Wu, Y., and Lee, C. H., “Development of a novel testing procedure for investigations of chordae mechanical properties of the tricuspid heart valve.” 38th Oklahoma AIAA/ASME Symposium, Edmond, OK, April 14, 2018.

68. Kunkel, R. P., Robinson, D., Laurence, D. W., Scherrer, J., Wang, J., Bohnstedt, B. N., Liu, Y, and Lee, C. H., “Synthesis and characterization of shape memory polymers for the embolization of intracranial aneurysms.” 38th Oklahoma AIAA/ASME Symposium, Edmond, OK, April 14, 2018.

67. Laurence, D. W., Wu, Y., and Lee, C. H., “Development of a multiscale computational modeling framework for the tricuspid valve.” 38th Oklahoma AIAA/ASME Symposium, Edmond, OK, April 14, 2018.

66. Ross, C., and Lee, C. H., “Development of a novel mechanical testing procedure for investigations of chordae mechanical properties of the tricuspid heart valve.” The 30th OU Undergraduate Research Day, The University of Oklahoma, Norman, OK, April 7, 2018.

65. Jett, S., and Lee, C. H., “A study on the spatial variation in the heart valve mechanical properties and microstructure.” National Conference on Undergraduate Research (NCUR 2018), Edmond, April 4-7, 2018.

64. Kramer, K., Babu, A., and Lee, C. H., “An experimental study for layer separation of the tricuspid and mitral valves to investigate their biomechanical properties.” National Conference on Undergraduate Research (NCUR 2018), Edmond, April 4-7, 2018.

63. Laurence, D. W., Mobaraki, M., and Lee, C. H., “Development of a novel integrated MRI-beating heart model for investigations into pathophysiological factors linked to tricuspid regurgitation.” National Conference on Undergraduate Research (NCUR 2018), Edmond, April 4-7, 2018.

62. Kunkel, R. P., Liu, Y., Bohnstedt, B. N., and Lee, C. H., “Synthesis and characterization of aliphatic urethane shape memory polymers for the treatment of intracranial aneurysms.” National Conference on Undergraduate Research (NCUR 2018), Edmond, April 4-7, 2018.

61. Ross, C., and Lee, C. H., “Investigations of the mechanical properties of chordae tendineae of atrioventricular heart valves.” National Conference on Undergraduate Research (NCUR 2018), Edmond, April 4-7, 2018.

60. Ross, C., Wu, Y., and Lee, C. H., “Development of a novel mechanical testing procedure for investigations of chordae mechanical properties of the tricuspid heart valve.” The 2nd OU-OUHSC Biomedical Engineering Symposium, Oklahoma City, OK, March 30, 2018.

59. Laurence, D. W., Wu, Y., and Lee, C. H., “An integrated experimental-computational framework for multiscale modeling of atrioventricular heart valves.” The 2nd OU-OUHSC Biomedical Engineering Symposium, Oklahoma City, OK, March 30, 2018.

58. Jett, S. and Lee, C. H., “Integration of biaxial mechanical testing and microstructural imaging for correlation of mechanical performance and collagen microstructure — applications to prosthetic tissue design and tissue engineering.” OU Gallogly College of Engineering Graduate Student Poster Fair, Norman, OK, November 10, 2017.

57. Wang, J., Chowdhury, S., Liu, Y., Bohnstedt, B., and Lee, C. H., “Development of thermally-activated shape memory polymers and composites for biomedical devices.” ASME 2017 International Mechanical Engineering Congress & Exposition, Tampa, FL, November 3-9, 2017.

56. Laurence, D. W., and Lee, C. H.,An integrated experimental-computational approach for multi-scale investigations of heart valve function - linking valve interstitial cell responses with tissue biomechanical behavior.” 2017 BMES Annual Meeting, Phoenix, AZ, October 11-14, 2017.

55. Ayoub, S., Lee, C. H., Potter, S. T., Graves, J. L., and Sacks, M. S., “A physiologically-driven biaxial bioreactor system to investigate valve interstitial cell phenotypic state after surgical repair.” 2017 BMES Annual Meeting, Phoenix, AZ, October 11-14, 2017.

54. Laurence, D. W., and Lee, C. H., “In-vivo stress estimation of the functioning heart valve and its implication for annuloplasty ring-based surgical repair.” The 2nd Curiosity to Creativity (C2C) Summer Symposium, The University of Oklahoma, Norman, OK, July 27, 2017.

53. Serrano, O., and Lee, C. H., “Biomechanical testing of heart valve tissues.” The 2nd Curiosity to Creativity (C2C) Summer Symposium, The University of Oklahoma, Norman, OK, July 27, 2017.

52. Sacks, M. S., Lee, C. H., and Zhang, W. “On the in-vivo function of the heart valve leaflet: insights into tissue-interstitial cell biomechanical modeling.” 14th U.S. National Congress on Computational Mechanics, Montreal, Canada, July 17-20, 2017.

51. Wang, J., Chowdhury, S., Liu, Y., Bohnstedt, B., and Lee, C. H., “Characterization of aliphatic urethane shape memory polymers for biomedical device design.” Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), Tucson, AZ, June 21-24, 2017.

50. Lee, C. H., and Sacks, M. S., “In-vivo stress estimation of the functioning heart valves and its implications for annuloplasty ring-based valve surgical repair.” Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), Tucson, AZ, June 21-24, 2017.

49. Lee, C. H., and Sacks, M. S., “An inverse modeling-based framework for in vivo modeling of the heart valves with investigations of the pre-strain effects.” Engineering Mechanics Institute Conference 2017, San Diego, CA, June 4-7, 2017

48. Ayoub, S., Lee, C. H., Potter, S. T., Graves, J. L., and Sacks, M. S., “Valve interstitial cell phenotypic state after surgical repair: an integrated experimental-computational approach.” 2017 BMES/FDA Frontiers in Medical Devices Conference, Washington, DC, May 16-18, 2017.

47. Laurence, D. W., and Lee, C. H., “A multi-scale computational model for patient-specific treatment of valvular heart diseases.” 37th Oklahoma AIAA/ASME Symposium, Tulsa, OK, April 15, 2017.

46. Lee, C. H., Liu, Y., and Bohnstedt, B. N., “Novel shape memory polymer devices for optimal endovascular embolization of intracranial aneurysms.” 1st OU-OUHSC Biomedical Engineering Symposium, Oklahoma City, OK, March 24, 2017.

45. Laurence, D. W., and Lee, C. H., “Development of a multi-scale mitral valve computational model for patient-specific treatment planning.” 1st OU-OUHSC Biomedical Engineering Symposium, Oklahoma City, OK, March 24, 2017.

44. Lee, C. H., and Sacks, M. S., “Effects of annuloplasty on in vivo MV tissue stress and cellular phenotype.” Heart Valve Society (HVS) Scientific Meeting, Grimaldi Forum, Monaco, March 2-4, 2017.

43. Lee, C. H., Feaver, K., Zhang, W., Gorman, R. C., Gorman, III, J. H., and Sacks, M. S., “Interrelationships between in vivo tissue stress and interstitial cell deformations in the mitral valve anterior leaflet in normal and surgically modified states.” 2016 BMES Annual Meeting, Minneapolis, MN, October 5-8, 2016.

42. Ayoub, S., Lee, C. H., Driesbaugh, K., Anselmo, W., Hughes, C. T., Ferrari, G., and Sacks, M. S., “Linking cell deformation to biosynthetic response: implications for mitral valve repair.” 2016 BMES Annual Meeting, Minneapolis, MN, October 5-8, 2016.

41. Lee, C. H., Feaver, K., Zhang, W., Gorman, R. C., Gorman, III, J. H., and Sacks, M. S., “Inverse modeling based estimation of in-vivo stresses and their relation to simulated layer-specific interstitial cell deformations in the mitral valve.” The Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C 2016), National Harbor, MD, June 29-July 2, 2016.

40. Feng, Y., Lee, C. H., Sun, L., and Fu, S., “Characterization of white matter using asymmetric indentation and inverse modeling in large strain.” The Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C 2016), National Harbor, MD, June 29-July 2, 2016.

39. Ayoub, S., Lee, C. H., Hughes, C. T., Ferrari, G., and Sacks, M. S., “Linking mitral valve interstitial cell deformation to biosynthetic response: implications for mitral valve repair.” The Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C 2016), National Harbor, MD, June 29-July 2, 2016.

38. Feng, Y., Lee, C. H., Sun, L., Okamoto, R. J., and Ji, S., “Automated estimation of elastic material parameters of a transversely isotropic material using asymmetric indentation and inverse finite element analysis.” ASME 2015 International Mechanical Engineering Congress and Exposition (ASME 2015 IMECE), Houston, TX, November 13-19, 2015.

37. Lee, C. H., Feaver, K., Zhang, W., and Sacks, M. S., “Inverse models for characterization of the in-vivo valvular mechanical behaviors.” 52nd Society of Engineering Science Annual Technical Meeting, College Stations, TX, October 26-28, 2015.

36. Ayoub, S., Khalighi, A. H., Lee, C. H., and Sacks, M. S., “The micro-geometric environment of mitral valve interstitial cells under physiological loading.” 52nd Society of Engineering Science Annual Technical Meeting, College Stations, TX, October 26-28, 2015.

35. Lee, C. H., Feaver, K., Zhang, W., and Sacks, M. S., “Estimation of the mitral valve in vivo stresses in the normal and surgically modified states.” 2015 BMES Annual Meeting, Tampa, FL, October 7-10, 2015.

34. Khalighi, A. H., Drach, A., Lee, C. H., Bloodworth, C. H., Pierce, E. L., Jensen, M. O., Yoganathan, A. P., Gorman, R. C., Gorman, III, J. H., and Sacks, M. S., “Development of a population-averaged model of the complete mitral valve geometry.” 2015 BMES Annual Meeting, Tampa, FL, October 7-10, 2015.

33. Lee, C. H., and Sacks, M. S., “On the effect of leaflet microstructure and constitutive model on the closing behavior of the mitral valve.” 13th U.S. National Congress on Computational Mechanics, San Diego, CA, July 26-30, 2015.

32. Khalighi, A. H., Drach, A., ter Huurne, F. M., Lee, C. H., Bloodworth, C. H., Pierce, E. L., Jensen, M. O., Yoganathan, A. P., and Sacks, M. S., “A comprehensive framework for the characterization of the complete mitral valve geometry for the development of a population-averaged model.” 8th International Conference on Functional Imaging and Modeling of the Heart (FIMH2015), Maastricht, the Netherlands, June 25-27, 2015.

31. Lee, C. H., Bloodworth, C. H., Jensen, M. O., Yoganathan, A. P., and Sacks, M. S., “Effects of leaflet microstructure and constitutive model on the closing behavior of the mitral valve.” The Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C2015), Snowbird, UT, June 17-20, 2015.

30. Lee, C. H., Carruthers, C. A., Ayoub, S., Gorman, R. C., Gorman, III, J. H., and Sacks, M. S., “Layer-specific mitral valve interstitial cell deformations under physiological loading.” The Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C2015), Snowbird, UT, June 17-20, 2015.

29. Ayoub, S., Khalighi, A. H., Lee, C. H., and Sacks, M. S., “Microgeometry and microenvironment of mitral valve interstitial cells under physiological loads.” The Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C2015), Snowbird, UT, June 17-20, 2015.

28. Lee, C. H., Bloodworth, C. H., Jensen, M. O., Yoganathan, A. P., and Sacks, M. S., “Predictive computational simulations of the functioning mitral valve.” BMES/FDA Frontiers in Medical Devices Conference, Washington, DC, May 18-20, 2015.

27. Khalighi, A. H., Drach, A., ter Huurne, F. M., Lee, C. H., Bloodworth, C. H., Pierce E. L., Jensen, M. O., Yoganathan, A. P., and Sacks, M. S., “Multi-scale geometric framework for population-averaging of the mitral valve apparatus.” BMES/FDA Frontiers in Medical Devices Conference, Washington, DC, May 18-20, 2015.

26. Drach, A., Khalighi, A. H., Lee, C. H., Jensen, M. O., Bloodworth, C. H., Yoganathan, A. P., and Sacks, M. S., “Population-averaged geometric model of mitral valve from patient-specific imaging data.” 14th Annual Design of Medical Devices Conference, Minneapolis, MN, April 13-16, 2015.

25. Lee, C. H., Carruthers, C. A., Good, B., Ayoub, S., Gorman, R. C., Gorman, III, J. H., and Sacks, M. S., “Integrated experimental-computational modeling of mitral valve interstitial cell deformation under in-situ physiological loading.” 2014 BMES Annual Meeting, San Antonio, TX, October 22-25, 2014.

24. Bloodworth, C. H., Pierce, E. L., Easley, T. F., Toma, M., Khalighi, A., Lee, C. H., Sacks, M. S., Siefert, A., Jensen, M. O., and Yoganathan, A. P., “Design of in vitro simulation pipeline for the development of computational mitral valve modeling.” 2014 BMES Annual Meeting, San Antonio, TX, October 22-25, 2014.

23. Lee, C. H., and Sacks, M. S., “A computational framework for Multiscale modeling of the mitral valve.” 6th Biennial Meeting on Heart Valve Biology & Tissue Engineering, London, the United Kingdom, September 10-12, 2014.

22. Lee, C. H., and Sacks, M. S., “A computational framework for Multiscale modeling of the mitral valve.” 11th World Congress on Computational Mechanics (WCCM XI), Barcelona, Spain, July 20-25, 2014.

21. Chi, S. W., Lee, C. H., Lin, S. P., and Chen, J. S., “Level set enhanced frictional kernel contact algorithm for impact and penetration modeling.” 11th World Congress on Computational Mechanics (WCCM XI), Barcelona, Spain, July 20-25, 2014.

20. Lee, C. H., Rabbah, J. P., Yoganathan, A. P., Amini, R., Gorman, III, J. H., Gorman, R. C., and Sacks, M. S., “A computational paradigm for modeling the functional mitral valve (MV) and MV surgical repair.” 7th World Congress of Biomechanics (WCB 2014), Boston, MA, July 6-11, 2014.

19. Lee, C. H., and Sacks, M. S., “A computational framework for Multiscale modeling of the mitral valve.” 17th U.S. National Congress on Theoretical & Applied Mechanics, East Lansing, MI, June 15-20, 2014.

18. Feaver, K., Zhang, W., Lee, C. H., Tam, H., McGarvey, J. R., Kondo, N., Gorman, R. C., Gorman, III, J. H., Vyavahare, N., and Sacks, M. S., “A novel experimental/numerical method to assess BHV biomaterial fatigue response in-vivo.” Society for Biomaterials 2014 Annual Meeting & Exposition, Denver CO, April 16-19, 2014.

17. Lee, C. H., Amini, R., Aggarwal, A., Gorman, R. C., Gorman, III, J. H., and Sacks, M. S., “Effects of local architectural mapping and material model on modeling the mitral valve.” 3rd International Conference on Computational and Mathematical Biomedical Engineering, Hong Kong, China, December 16-18, 2013.

16. Lee, C. H., Gorman, III, J. H., Gorman, R. C., Amini, R., and Sacks, M. S., “A micro-anatomically accurate finite element model for investigation of functioning mitral valve and its relationship to interstitial cell deformations.” 2013 BMES Annual Meeting, Seattle, WA, September 25-28, 2013

15. Lee, C. H., and Chen, J. S., “Multi-scale simulation of protein-induced DNA loop formation.” 12th U.S. National Congress on Computational Mechanics, Raleigh, NC, July 22-25, 2013 (keynote presentation).

14. Lee, C. H., Oomen, P. J. A., Rabbah, J. P., Saikrishnan, N., Yoganathan, A. P., Gorman, R. C., Gorman, III, J. H., and Sacks, M. S., “A high-fidelity, micro-structurally & anatomically accurate 3D finite element model for functioning heart mitral valve.” Proceedings of the ASME 2013 Summer Bioengineering Conference (SBC2013), Sun River, OR, June 26-29, 2013.

13. Aggarwal, A., Aguiliar, V. S., Lee, C. H., Ferrari, G., Gorman, III, J. H., Gorman, R. C., and Sacks, M. S., “Spline based microstructural mapping for soft biological tissues: application to aortic valves.” Proceedings of the ASME 2013 Summer Bioengineering Conference (SBC2013), Sun River, OR, June 26-29, 2013.

12. Sacks, M. S., Lee, C. H., Gorman, III, J. H., Gorman, R. C., and Yoganathan, A. P., “A high-fidelity micro-structurally and anatomically accurate 3D finite element model for functioning heart mitral valve.” 7th Biennial Congress of the Society of Heart Valve Disease, Venice, Italy, June 22-25, 2013.

11. Lee, C. H., Oomen, P. J. A., Rabbah, J. P., Yoganathan, A. P., Gorman, R. C., Gorman, III, J. H., Amini, R., and Sacks, M. S., “A high-fidelity and micro-anatomically accurate 3D finite element model for simulations of functional mitral valve.” 7th International Conference on Functional Imaging and Modeling of the Heart (FIMH2013), London, United Kingdom, June 20-22, 2013.

10. Aggarwal, A., Aguiliar, V. S., Lee, C. H., Ferrari, G., Gorman, III, J. H., Gorman, R. C., and  Sacks, M. S., “Patient-specific modeling of heart valves: from images to simulation.” 7th International Conference on Functional Imaging and Modeling of the Heart (FIMH2013), London, United Kingdom, June 20-22, 2013.

9. Chi, S. W., Lee, C. H., Lin, S. P., and Chen, J. S., “A level set enhanced kernel contact algorithm for fragment-impact problems.” 3rd South-East European Conference on Computational Mechanics, Kos Island, Greece, June 12-14, 2013.

8. Lee, C. H., and Chen, J. S., “Multi-scale modeling of protein-mediated DNA loop formation.” ASME 2012 International Mechanical Engineering Congress & Exposition, Houston, TX, November 9-15, 2012 (keynote presentation).

7. Lee, C. H., and Chen, J. S., “POD-based model order reduction for molecular dynamics with radial basis represented force fields.” 3rd International Symposium on Computational Mechanics and 2nd Symposium on Computational Structural Engineering (ISCM III & CSE II), Taipei, Taiwan, December 5-7, 2011.

6. Lee, C. H., and Chen, J. S., “POD-based reduced-order simulation for DNA molecules.” 11th U.S. National Congress on Computational Mechanics, Minneapolis, MN, July 25-29, 2011.

5. Roth, J. M., Chen, J. S., Slawson, T. R., Roone, N., Ren, X., Chi, S. W., Lee, C. H., and Guan, P. C., “Multiscale RKPM formulation for modeling penetration of an ultra-high strength concrete material.” 3rd International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering (COMPDYN 2011), Corfu, Greece, May 26-28, 2011.

4. Chen, J. S., Chi, S. W., Lee, C. H., Roth, J. M., and Slawson, T. R., “Micro-crack informed multi-scale damage model for fragment-impact modeling.” International Union of Theoretical and Applied Mechanics Symposium Linking Scales in Computations: From Microstructure to Macro-Scale Properties, Pensacola, FL, May 17-19, 2011.

3. Lee, C. H., Teng, H., and J.S. Chen, J. S., “Atomistic to continuum modeling of DNA molecules.” 1st Global Congress on NanoEngineering for Medicine and Biology (NEMB 2010), Houston, TX, February 7-10, 2010.

2. Lee, C. H., Teng, H., and Chen, J. S., “Atomistic to continuum modeling of DNA molecules.” 10th U.S. Congress on Computational Mechanics, Columbus, OH, July 16-19, 2009.

1. Leu, L. J., Lee, C. H., Wang, C. K., and Zhang, M. K., “Object-oriented optimization system using commercial package as the analysis engine.” the 8th U.S. National Congress on Computational Mechanics (USNCCM-8), Austin, TX, July 25-27, 2005.

    

Invited Seminars/Talks

13. Towards Biomechanical Simulation-Guided Diagnosis and Treatment of Valvular Heart Disease, Invited Lecture in the Department of Structural Engineering & Computational Mechanics Seminar, University of California, San Diego (UCSD), La Jolla, CA, January 23, 2019

12. Precision Medicine for Cardiovascular Heart Valve Biomechanics, Invited Lecture in the MAE Seminar Series, Mechanical and Aerospace Engineering, Oklahoma State University, Stillwater, OK, April 13, 2018

11. Multiscale Modeling of DNA Molecules, Invited Lecture in the Applied Mathematics Seminar, Department of Mathematics, The University of Oklahoma, Norman, OK, October 17, 2017

10. Biomechanical Modeling for Heart Valves, Guest Lecture in BME 2333 (Biomedical Engineering Fundamentals), Stephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK, November 17, 2106

9. What We Can Learn From Biomechanical Modeling – Insights Into Physiological Functioning of the Heart Valves? Guest Lecture in Graduate Student Community Seminar Series, School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK, November 8, 2016

8. Integrated Computational-Experimental Modeling for Heart Valve Biomechanics, School of Mechanical and Electrical Engineering, Robotics and Microsystems Center, Soochow University, Suzhou, China, June 7, 2016

7. Multiscale Biomechanics – Bridging Molecular Biology, Cell Mechanobiology, Tissue Mechanics with Organ-Level Function, Department of Civil Engineering, National Taiwan University, Taipei, Taiwan, March 17, 2016

6. Computational & Experimental Modeling for Multiscale Biomechanics – Bridging Molecular Biology, Cell Mechanobiology, Tissue Micromechanics with Organ-Level Function, School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK, March 8, 2016

5. Multiscale Biomechanical Modeling – Bridging Molecular Biology, Cell Mechanobiology, Tissue Mechanics with Organ-Level Function, Department of Biomedical Engineering, Pennsylvania State University, State College, PA, February 24, 2016

4. Computational and Experimental Modeling for Multiscale Biomechanics – Bridging Molecular Biology, Cell Mechanobiology, Tissue Micromechanics with Organ-Level Function, Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, February 11, 2016

3. Multiscale Computational Biomechanical Modeling – Bridging Molecular Biology, Cell Mechanobiology, Tissue Mechanics with Organ-Level Function, Department Agricultural and Biomedical Engineering, Louisiana State University, Baton Rouge, LA, January 27, 2016

2. Predictive Computational Modeling & Design for Engineering and Sciences, Department of Civil Engineering, National Taiwan University, Taipei, Taiwan, March 13, 2014

1. Atomistic to Continuum Modeling of DNA Molecules, Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, December 15, 2011