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Research Projects

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BBDL Research Projects

Dr. Lee's Biomechanics and Biomaterials Design Laboratory (BBDL) at the University of Oklahoma aims to interfaces multi-scale cardiovascular biomechanical modeling and experimental tissue mechanics with biomedical engineering and promotes bioengineering and STEM research in two main research areas: (i) Cardiovascular Tricuspid Heart Valve Biomechanics, and (ii) Personalized Diagnosis and Treatment of Intracranial Aneurysms.

Our long-term scientific vision is to advance the fundamental understanding of the biomechanics, morphology, and tissue-microstructure interactions of the tricuspid heart valve, especially when the tricuspid valve (TV) is under a hyper- or hypo-physiological environment. All these biomechanical and microstructural aspects are essential to maintain the tricuspid valve’s homeostasis in response to disease-induced growth and remodeling (G&R) processes.

Project 1 - Biaxial Mechanical Testing for Soft Biological Tissues

  • Jounal Publications:
    (1) Colton Ross, Devin Laurence, Yi Wu, and Chung-Hao Lee, "Biaxial mechanical characterizations of atrioventricular heart valves." JoVE (Journal of Visualized Experiments) 146 (2019): e59170.
    (2) Samuel Jett, Devin Laurence, Robert Kunkel, Anju R. Babu, Katherine
    Kramer, Ryan Baumwart, Rheal Towner, Yi Wu, and Chung-Hao Lee, "Biaxial mechanical data of porcine atrioventricular valve leaflets." Data in Brief 21 (2018): 358-363.
    (3) Devin Laurence, Colton Ross, Samuel Jett, Cortland Johns, Allyson Echols, Ryan Baumwart, Rheal Towner, Jun Liao, Pietro Bajona, Yi Wu, and Chung-Hao Lee, "Regional biaxial mechanical data of the mitral and tricuspid valve anterior leaflets." Data in Brief 24 (2019): 103961.
    (4) Chung-Hao Lee, Devin Laurence, Colton Ross, Katherine Kramer, Anju Babu, Emily Johnson, Ming-Chen Hsu, Ankush Aggarwal, Arshid Mir, Harold Burkhart, Rheal Towner, Ryan Baumwart, and Yi Wu, "Mechanics of the tricuspid valve—From clinical diagnosis/treatment, in-vivo and in-vitro investigations, to patient-specific biomechanical modeling." Bioengineering 6(2) (2019): 47.
     

Project 2 - Biaxial Mechanical Behaviors of Porcine TV Leaflets

Project 3 - Regional Variations in the TV Tissue's Biaxial Mechanics

  • Jounal Publication:  Devin Laurence, Colton Ross, Samuel Jett, Cortland Johns, Allyson Echols, Ryan Baumwart, Rheal Towner, Jun Liao, Pietro Bajona, Yi Wu, and Chung-Hao Lee, "An investigation of regional variations in the biaxial mechanical properties and stress relaxation behaviors of porcine atrioventricular heart valve leaflets." Journal of biomechanics 83 (2019): 16-27.
     

Project 4 - Layer-Specific TV Biomechanics

  • Jounal Publication:  Katherine Kramer, Ross, Colton, Laurence, Devin, Babu Anju, Yi Wu, Rheal Towner, Arshid Mir, Harold Burkhart, Gerhard Holzapfel, and Chung-Hao Lee, "An investigation of layer-specific tissue biomechanics of porcine atrioventricular valve anterior leaflets." Acta Biomaterialia (2019).
     

Project 5 - GAG's Contribution to Tissue Biomechanics of the TV

  • Jounal Publication:  Colton, Ross, Devin Laurence, Jacob Richardson, Anju Babu, Lauren Evans, Ean Beyer, Rachel Childers, Yi Wu, Rheal Towner, Kar-Ming Fung, Arshid Mir, Harold Burkhart, Gerhard Holzapfel, and Chung-Hao Lee, "An investigation of the glycosaminoglycan contribution to biaxial mechanical behaviours of porcine atrioventricular heart valve leaflets." Journal of the Royal Society Interface 16(156) (2019): 20190069
     

Project 6 - Isogeometric Analysis-Based Simulations of TV Function

The long-term goals of our research program in this research area are (i) to significantly improve endovascular embolization treatment outcomes for individuals with a brain aneurysm, based on advances in shape memory polymers and a better understanding of how arterial and aneurysm tissues interact with intracranial circulation, and (ii) to to facilitate personalized diagnosis and management of unruptured aneurysms and their potentially rupture-induced subarachnoid hemorrhage (SAH).

Project 1 - Characterization of Pristine Aliphatic Urethane SMPs

  • Jounal Publication:  Robert, Kunkel, Devin Laurence, Jingyu Wang, Donnie Robinson, Joshua Scherrer, Yi Wu, Bradley Bohnstedt, Aichi Chien, Yingtao Liu, and Chung-Hao Lee, "Synthesis and characterization of bio-compatible shape memory polymers with potential applications to endovascular embolization of intracranial aneurysms." Journal of the mechanical behavior of biomedical materials 88 (2018): 422-430.
     

Project 2 - Development of Highly Porous Shape Memory Polymer Foams

  • Jounal Publications:
    (1)  Jingyu Wang, Robert Kunkel, Jishan Luo, Yuhua Li, Hong Liu, Bradley N. Bohnstedt, Yingtao Liu, and Chung-Hao Lee, "Shape memory polyurethane with porous architectures for potential applications in intracranial aneurysm treatment." Polymers 11, no. 4 (2019): 631.
    (2) Jingyu Wang, Jishan Luo, Robert Kunkel, Mrinal Saha, Bradley N. Bohnstedt, Chung-Hao Lee, and Yingtao Liu, "Development of shape memory polymer nanocomposite foam for treatment of intracranial aneurysms." Materials Letters 250 (2019): 38-41