BBDL Research Projects
Dr. Lee's Biomechanics and Biomaterials Design Laboratory (BBDL) at the University of Oklahoma aims to interfaces multi-scale cardiovascular biomechanical modeling and experimental tissue mechanics with biomedical engineering and promotes bioengineering and STEM research in two main research areas: (i) Cardiovascular Tricuspid Heart Valve Biomechanics, and (ii) Personalized Diagnosis and Treatment of Intracranial Aneurysms.
Our long-term scientific vision is to advance the fundamental understanding of the biomechanics, morphology, and tissue-microstructure interactions of the tricuspid heart valve, especially when the tricuspid valve (TV) is under a hyper- or hypo-physiological environment. All these biomechanical and microstructural aspects are essential to maintain the tricuspid valve’s homeostasis in response to disease-induced growth and remodeling (G&R) processes.
Project 1 - Biaxial Mechanical Testing for Soft Biological Tissues
- Jounal Publications:
(1) Colton Ross, Devin Laurence, Yi Wu, and Chung-Hao Lee, "Biaxial mechanical characterizations of atrioventricular heart valves." JoVE (Journal of Visualized Experiments) 146 (2019): e59170.
(2) Samuel Jett, Devin Laurence, Robert Kunkel, Anju R. Babu, Katherine
Kramer, Ryan Baumwart, Rheal Towner, Yi Wu, and Chung-Hao Lee, "Biaxial mechanical data of porcine atrioventricular valve leaflets." Data in Brief 21 (2018): 358-363.
(3) Devin Laurence, Colton Ross, Samuel Jett, Cortland Johns, Allyson Echols, Ryan Baumwart, Rheal Towner, Jun Liao, Pietro Bajona, Yi Wu, and Chung-Hao Lee, "Regional biaxial mechanical data of the mitral and tricuspid valve anterior leaflets." Data in Brief 24 (2019): 103961.
(4) Chung-Hao Lee, Devin Laurence, Colton Ross, Katherine Kramer, Anju Babu, Emily Johnson, Ming-Chen Hsu, Ankush Aggarwal, Arshid Mir, Harold Burkhart, Rheal Towner, Ryan Baumwart, and Yi Wu, "Mechanics of the tricuspid valve—From clinical diagnosis/treatment, in-vivo and in-vitro investigations, to patient-specific biomechanical modeling." Bioengineering 6(2) (2019): 47.
Project 2 - Biaxial Mechanical Behaviors of Porcine TV Leaflets
- Jounal Publication: Jett, Samuel, Devin Laurence, Robert Kunkel, Anju R. Babu, Katherine Kramer, Ryan Baumwart, Rheal Towner, Yi Wu, and Chung-Hao Lee, "An investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valves." Journal of the mechanical behavior of biomedical materials 87 (2018): 155-171.
Project 3 - Regional Variations in the TV Tissue's Biaxial Mechanics
- Jounal Publication: Devin Laurence, Colton Ross, Samuel Jett, Cortland Johns, Allyson Echols, Ryan Baumwart, Rheal Towner, Jun Liao, Pietro Bajona, Yi Wu, and Chung-Hao Lee, "An investigation of regional variations in the biaxial mechanical properties and stress relaxation behaviors of porcine atrioventricular heart valve leaflets." Journal of biomechanics 83 (2019): 16-27.
Project 4 - Layer-Specific TV Biomechanics
- Jounal Publication: Katherine Kramer, Ross, Colton, Laurence, Devin, Babu Anju, Yi Wu, Rheal Towner, Arshid Mir, Harold Burkhart, Gerhard Holzapfel, and Chung-Hao Lee, "An investigation of layer-specific tissue biomechanics of porcine atrioventricular valve anterior leaflets." Acta Biomaterialia (2019).
Project 5 - GAG's Contribution to Tissue Biomechanics of the TV
- Jounal Publication: Colton, Ross, Devin Laurence, Jacob Richardson, Anju Babu, Lauren Evans, Ean Beyer, Rachel Childers, Yi Wu, Rheal Towner, Kar-Ming Fung, Arshid Mir, Harold Burkhart, Gerhard Holzapfel, and Chung-Hao Lee, "An investigation of the glycosaminoglycan contribution to biaxial mechanical behaviours of porcine atrioventricular heart valve leaflets." Journal of the Royal Society Interface 16(156) (2019): 20190069.
Project 6 - Isogeometric Analysis-Based Simulations of TV Function
- Jounal Publication: David Kamensky, Fei Xu, Chung-Hao Lee, Jinhui Yan, Yuri Bazilevs, and Ming-Chen Hsu. "A contact formulation based on a volumetric potential: Application to isogeometric simulations of atrioventricular valves." Computer methods in applied mechanics and engineering 330 (2018): 522-546.
The long-term goals of our research program in this research area are (i) to significantly improve endovascular embolization treatment outcomes for individuals with a brain aneurysm, based on advances in shape memory polymers and a better understanding of how arterial and aneurysm tissues interact with intracranial circulation, and (ii) to to facilitate personalized diagnosis and management of unruptured aneurysms and their potentially rupture-induced subarachnoid hemorrhage (SAH).
Project 1 - Characterization of Pristine Aliphatic Urethane SMPs
- Jounal Publication: Robert, Kunkel, Devin Laurence, Jingyu Wang, Donnie Robinson, Joshua Scherrer, Yi Wu, Bradley Bohnstedt, Aichi Chien, Yingtao Liu, and Chung-Hao Lee, "Synthesis and characterization of bio-compatible shape memory polymers with potential applications to endovascular embolization of intracranial aneurysms." Journal of the mechanical behavior of biomedical materials 88 (2018): 422-430.
Project 2 - Development of Highly Porous Shape Memory Polymer Foams
- Jounal Publications:
(1) Jingyu Wang, Robert Kunkel, Jishan Luo, Yuhua Li, Hong Liu, Bradley N. Bohnstedt, Yingtao Liu, and Chung-Hao Lee, "Shape memory polyurethane with porous architectures for potential applications in intracranial aneurysm treatment." Polymers 11, no. 4 (2019): 631.
(2) Jingyu Wang, Jishan Luo, Robert Kunkel, Mrinal Saha, Bradley N. Bohnstedt, Chung-Hao Lee, and Yingtao Liu, "Development of shape memory polymer nanocomposite foam for treatment of intracranial aneurysms." Materials Letters 250 (2019): 38-41.