A dominant 2R wing mutation in Drosophila melanogaster.

Rusev, D.¹, R. Atanasova¹, A. Wolstenholme², and E. Semenov¹.  ¹Institute of Molecular Biology, Sofia, Bulgaria;  ²University of Bath, Bath, UK;  esen@obzor.bio21.bas.bg

     The phenotype of an EMS-induced dominant mutation Cul (Curled-like) is very similar to that of Curled (2-54.6):  wings are strongly curved upward (see Lindsley and Zimm, 1985).  The results of recombinational mapping showed 556 recombinants with brown among 1797 flies analyzed, which placed Cul at approximately 2-73.6 ± 2.1 of the genetic map.  Both the fertility and sex ratio of the mutant flies are near to normal.  Light microscopy examination of the entire polytene chromosome 2 has not revealed detectable rearrangements.  More detailed analysis of the 49E-53F region (corresponding to the 67.0-77.3 region, where Cul was mapped genetically), also did not show any changes in the chromosome banding pattern.  The mutant stock is maintained and available as Cul;st. 

     Acknowledgments:  The work was supported by a Collaborative Research Initiative grant from the Wellcome Trust (award no. 056780).

     References:  Lindsley, D., and G. Zimm 1985, Dros. Inf. Serv. 62: 75-76.