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Integrative Immunology Center

OU-Tulsa Schusterman Center
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Integrative Immunology Center

Integrative Immunology Center

The threefold mission of the Integrative Immunology Center is to:

  • Facilitate interdisciplinary research in community medicine focused on understanding the long-term biological effects of psychosocial and physical stress
  • Deliver educational support and specialized expertise in the field of immunology to the Tulsa community
  • Provide state-of-the-art core laboratory services for faculty and students engaged in translational research

Integrative Immunology Center

University of Oklahoma-Tulsa
4502 E 41st St.
Tulsa, OK 74135


Phone: 918-660-3920
Fax: 918-660-3928

Kent Teague
researcher ID

Kent Teague, Ph.D.

Center Director

Kent Teague, Ph.D. is the Center Director and also the Associate Dean for Research at the University of Oklahoma School of Community Medicine.  Dr. Teague is a professor in the Department of Surgery and an adjunct professor in the Department of Psychiatry at the School of Community Medicine.  He is also an adjunct associate professor at the Oklahoma State University Center for Health Sciences and an adjunct professor at the University of Oklahoma College of Pharmacy.  He holds the George Kaiser Family Foundation Chair in Community Medicine Research.  He completed his Ph.D. in Biological Sciences at the University of Texas M.D. Anderson Cancer Center in Houston.  He completed a postdoctoral fellowship in Immunology at the Howard Hughes Medical Institute at the National Jewish Research Center in Denver.  


Kent-teague@ouhsc.edu  

Julie Marino

Julie Marino, Ph.D.

Instructor

Dr. Julie H. Marino is a faculty member in the Department of Surgery at the University of Oklahoma, School of Community Medicine, Tulsa.  She received her Bachelor of Arts in Biology from Covenant College before completing her PhD in Immunology at the University of Tulsa. She completed post-doctoral training in the Department of Surgery at the University of Oklahoma College of Medicine in Tulsa.  She is an expert in gene expression analysis and directs the genomics research efforts at the Integrative Immunology Center.

Julie-marino@ouhsc.edu  

ashlee taylor

Ashlee Rempel, B.S., M.B.A.

Laboratory Business Manager

Ashlee Rempel serves as the Integrative Immunology Center Laboratory Manager and Business Manager.  Ashlee has been employed at the University of Oklahoma since 2002, beginning as a Research Assistant II in the Department of Pediatrics at the OUHSC in Oklahoma City.  She joined OU - Tulsa as a Research Assistant II in 2005.  She assumed the role of Research Associate and Laboratory Manager in 2009.  She has a Bachelor of Science in Microbiology and a Master's in Business Administration from Oklahoma State University.  She is a certified flow cytometrist and an expert in flow-based cytokine bead arrays, ELISA, MSD arrays, and other biomarker technologies.

Ashlee-rempel@ouhsc.edu 

 

chibing tan

Chibing Tan, Ph.D.

Research Associate

Dr. Chibing Tan directs the Flow Cytometry Laboratory at the Integrative Immunology Center.  He is an expert in multiparametric flow cytometry.  He is a certified operator of the MoFlo™ XDP high-speed cell sorter.  He earned his PhD in Polymer Chemistry and Physics at the Chinese Academy of Sciences, Beijing, China.  He completed a postdoctoral fellowship in Biochemistry and Biophysics at the OUHSC in Oklahoma City and a second postdoctoral fellowship in Immunology at the University of Oklahoma School of Community Medicine in Tulsa.

Chibing-tan@ouhsc.edu

brenda davis

Brenda Davis, B.S.

Research Assistant II

Brenda Davis is a senior research technician with extensive experience in molecular biology and recombinant DNA technology.  She serves as the Integrative Immunology Center’s clinical studies coordinator and oversees human tissue processing and cryogenic storage. She earned a Bachelor of Science in Biochemistry from The Oklahoma State University.  Brenda Davis also serves as the Oklahoma Willed Body Program’s OU-Tulsa campus representative and is responsible for scheduling and coordination of the OU-Tulsa Anatomy Laboratory.

Brenda-davis@ouhsc.edu      

Debbie Neal

Debbie Neal, B.S.

Senior Administrative Assistant

Debbie Neal serves as the senior administrative assistant for the Integrative Immunology Center.  She also assists the Laboratory Manager in ensuring laboratory regulatory compliance.  She has a Bachelor of Science in Environmental Management at Northeastern Oklahoma State University.  

Debbie-neal@ouhsc.edu

 

Michael Torres

Michael Torres, B.S.

Research Technician

Michael Torres is a Research Technician at the Integrative Immunology Center. He assists the lab in blood/tissue processing and biomarker assays. He earned his BS in Health Science from the University of Oklahoma in 2016.

Michael-Torres@ouhsc.edu

Laureate Institute for Brain Research

Jonathan Savitz, Ph.D. Principal Investigator, Laureate Institute for Brain Research and Associate Professor, University of Tulsa

Projects: Neuroimaging abnormalities in major depressive disorder: Effect of inflammation (NIH - 1K01MH096077); Response to Inflammatory Challenge in Major Depressive Disorder (NIH - P20GM131212-01); Inflammatory transcripts, genes and positive valence system function in anhedonia (NIMH - 1R01MH098099)  

 

Jerzy Bodurka, Ph.D. Chief Technology Officer, Laureate Institute for Brain Research, Associate Professor, University of Oklahoma College of Engineering

Project: Neuroscience-Based Mental Health Assessment and Prediction (NeuroMAP)- Center of Biomedical Research Excellence - (NIH - P20GM131212-01); Inflammatory transcripts, genes and positive valence system function in anhedonia (NIMH - 1R01MH098099)  

 

Medical College of Wisconsin

Timothy Meier, Ph.D Assistant Professor of Neurosurgery, Department of Neurosurgery

Project: Inflammation and kynurenine metabolites in the acute sequelae of concussion (NIMH - 1R21NS099789)

 

Oklahoma State University Center for Health Sciences

Jennifer Hays-Grudo, Ph.D. Professor, Department of Human Development and Family Science

Projects: Child Cortisol Levels and Family Stress; Center for Integrated Research on Childhood Adversity Administrative Core - (NIH - P20GM109097)

 

Kenneth E. Miller, Ph.D. Professor and Chair of Anatomy & Cell Biology, College of Osteopathic Medicine

Project: The Role of Glutamatergic Sensory Neurons in the Initiation of and Response to Colitis. (OCAST HR16-003)

 

Oklahoma State University - Stillwater

Ronald Cox, Ph.D. Associate Professor, Center for Family Resilience, Department of Human Development and Family Science

Project: Juntos Se Puede - Center for Integrated Research on Childhood Adversity (NIH - P20GM109097)

 

Julie Croff, Ph.D. Assistant Professor, School of Applied Health and Education Psychology

Project: Examining Epidemiology of Folate Status Attributable to Adolescent Alcohol Use - Center for Integrated Research on Childhood Adversity  (NIH - P20GM109097)

 

Isaac Washburn, Ph.D. Assistant Professor, Department of Human Development and Family Science

Project: Center for Integrated Research on Childhood Adversity Statistics Core (NIH - P20GM109097)

 

Oklahoma State University - Tulsa

Amanda Sheffield Morris, Ph.D. Regents' Professor and George Kaiser Family Foundation Endowed Chair in Child Development, Center for Family Resilience, Department of Human Development and Family Science

Project: The Dyadic Inter-Brain Signaling (DIBS) Project: Modeling Parent-Child Inter-Brain Regulation in the Prediction of Adolescent Depressive Symptoms - Center for Integrated Research on Childhood Adversity (NIH - P20GM109097)

 

Karina Shreffler, Ph.D. Professor, Center for Family Resilience, Department of Human Development and Family Science

Project: Holistic Assessment of Tulsa Children's Health (HATCH) - Center for Integrated Research on Childhood Adversity (NIH - P20GM109097)

 

University of Nebraska

Hideo Suzuki, Ph.D Assistant Professor, Department of Educational Psychology, University of Nebraska-Lincoln; Faculty Affiliate, Center for Brain, Biology and Behavior

Project: Inflammatory transcripts, genes and positive valence system function in anhedonia (NIMH - 1R01MH098099)  

 

University of Oklahoma Health Sciences Center

David Bard, Ph.D. Director, Biomedical and Behavioral Methodology Core (BBMC) , Associate Professor, Department of Pediatrics, OU College of College of Medicine

Project: Maternal, Infant, and Early Childhood Home Visiting Program: A Collaborative Learning Innovation for Addressing Engagement/ Retention of Home Visiting (HRSA/OSDH UH4MC307450100)  

 

Alicia Salvatore, Dr.PH, M.P.H. Assistant Professor, Department of Health Promotion Sciences, OU College of Public Health

Project: Examining Work Stress and Health Among Latinas (NIGMS U54 GM104938)  

 

University of Oklahoma - Tulsa

Jameca Price, M.D., M.P.H., M.C.R. Assistant Professor, Associate Director of Clinical Resarch, Department of Obstetrics and Gynecology, School of Community Medicine

Projects: Recurrent urinary tract infections and heparin: a double-blind randomized trial

(COMAA 20171706)

 

Julie Miller-Cribbs, Ph.D. Professor, Director, Anne and Henry Zarrow School of Social Work

Projects: Child Cortisol Levels and Family Stress; School of Community Medicine Summer Institute Evaluation

 

Diane Horm, Ph.D. George Kaiser Family Foundation Professor of Early Childhood Education
; Director, Early Childhood Education Institute

Project: Child Cortisol Levels and Family Stress

 

University of Tulsa

Brett McKinney, Ph.D Associate Professor, William K. Warren, Jr. Endowed Chair in Bioinformatics, Tandy School of Computer Science and Department of Mathematics

Project: Neuroscience-Based Mental Health Assessment and Prediction (NeuroMAP)- Center of Biomedical Research Excellence - (NIH - P20GM131212-01)

 

Matteo Avella, Ph.D Assistant Professor of Biology, Department of Biological Science, College of Engineering and Natural Sciences

Project: Molecular biology and Genetics of mouse and human reproduction  

 
  1. Ford BN, Yolken RH, Aupperle RL, Teague TK, Irwin MR, Paulus MP, Savitz J. Association of Early-Life Stress With Cytomegalovirus Infection in Adults With Major Depressive Disorder. JAMA Psychiatry. 2019 Mar 6. PMID: 30840037
  2. Le, TT, Savitz, J, Suzuki, H, Misaki, M, Teague, TK, White, B, Marino, JH, Wiley, G, Gaffney, P, Drevets, W, McKinney, B, Bodurka. Identification and replication of RNA-Seq gene network modules associated with depression severity. Translational Psychiatry. Sep 5, 2018 8(1), 180. PMID: 30185774
  3. Simmons, K, Burrows, K, Avery, J, Kerr, K, Taylor, A, Bodurka, J, Potter, W, Teague, TK, Drevets, W.  Appetite Changes Reveal Depression Subgroups with Distinct Endocrine, Metabolic, and Immune States. Molecular Psychiatry. 2018 Jun 13. PMID: 29899546
  4. Ford, BN, Yolken, RH, Dickerson, FB, Teague, TK, Irwin, MR, Paulus, MP, Savitz, J. Reduced Immunity to Measles in Adults with Major Depressive Disorder. Psychological Medicine. 2018  Mar 1-7. PMID: 29552990.
  5. Savitz J, Teague TK, Misaki M, Macaluso M, Wurfel B., Meyer M., Drevets D, Yates W, Gleason OC, Drevets W, Preskorn S. Treatment of Bipolar Depression with Minocycline and/or Aspirin: An adaptive, 2 X 2 double-blind, randomized, placebo-controlled, phase IIA clinical trial. Transl Psychiatry. 2018 Jan 24;8(1):27. PMID: 29362444
  6. Meier TB, Drevets WC, Teague TK, Wurfel BE, Mueller SC, Bodurka J, Dantzer R, Savitz J. Kynurenic acid is reduced in females and oral contraceptive users: Implications for depression. Brain, Behavior, and immunity. 2018 Jan 67:59-64. PMID: 28867283
  7. Suzuki H, Savitz, J, Teague TK, Gandhapudi SK, Tan, C, Misaki M, McKinney BA, Irwin, MR, Drevets, WC, Bodurka, J. Altered Populations of Natural Killer Cells, Cytotoxic T Lymphocytes, and Regulatory T Cells in Major Depressive Disorder: Association with Sleep Disturbance. Brain Behav Immun. 2017 Nov 66:193-200. PMID: 28645775 
  8. Cho HJ, Savitz J, Dantzer R, Teague TK, Drevets WC, Irwin MR. Sleep disturbance and kynurenine metabolism in depression. J Psychosom Res. 2017 Aug;99:1-7. PMID: 28712413.
  9. Wurfel BE, Drevets WC, Bliss SA, McMillin JR, Suzuki H, Ford BN, Morris HM, Teague TK, Dantzer R, Savitz JB. Serum kynurenic acid is reduced in affective psychosis. Transl Psychiatry. 2017 May 2;7(5):e1115. PMID: 28463241.
  10. Meier TB, Lancaster MA, Mayer AR, Teague TK, Savitz J. Abnormalities in Functional Connectivity in Collegiate Football Athletes with and without a Concussion History: Implications and Role of Neuroactive Kynurenine Pathway Metabolites. J Neurotrauma. 2017 Feb 15;34(4):824-837. PMID: 27618518.
  11. Young KD, Drevets WC, Dantzer R, Teague TK, Bodurka J, Savitz J. Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression. Brain Behav Immun. 2016 Aug;56:335-42. PMID: 27091600
  12. Meier TB, Savitz J, Singh R, Teague TK, Bellgowan PS. Smaller Dentate Gyrus and CA2 and CA3 Volumes Are Associated with Kynurenine Metabolites in Collegiate Football Athletes. J Neurotrauma. 2016 Jul 15;33(14):1349-57. PMID: 26493952
  13. Singh R, Savitz J, Teague TK, Polanski DW, Mayer AR, Bellgowan PS, Meier TB. Mood symptoms correlate with kynurenine pathway metabolites following sports-related concussion. J Neurol Neurosurg Psychiatry. 2016 Jun;87(6):670-5. PMID: 26269650.
  14. Meier TB, Drevets WC, Wurfel BE, Ford BN, Morris HM, Victor TA, Bodurka J, Teague TK, Dantzer R, Savitz J. Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder. Brain Behav Immun. 2016 Mar;53:39-48. PMID: 26546831
  15. Meier TB, Bergamino M, Bellgowan PS, Teague TK, Ling JM, Jeromin A, Mayer AR. Longitudinal assessment of white matter abnormalities following sports-related concussion. Hum Brain Mapp. 2016 Feb;37(2):833-45. PMID: 26663463.
  16. Savitz J, Dantzer R, Meier TB, Wurfel BE, Victor TA, McIntosh SA, Ford BN, Morris HM, Bodurka J, Teague TK, Drevets WC. Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder. Psychoneuroendocrinology. 2015 Dec;62:54-
  17. Savitz J, Drevets WC, Wurfel BE, Ford BN, Bellgowan PS, Victor TA, Bodurka J, Teague TK, Dantzer R. Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder. Brain Behav Immun. 2015 May;46:55-9. PMID: 25686798
  18. Gandhapudi SK, Tan C, Marino JH, Taylor AA, Pack CC, Gaikwad J, Van De Wiele CJ, Wren JD, Teague TK. IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol. 2015 Apr 15;194(8):3820-8. PMID: 25780034
  19. Savitz J, Dantzer R, Wurfel BE, Victor TA, Ford BN, Bodurka J, Bellgowan PS, Teague TK, Drevets WC. Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. Psychoneuroendocrinology. 2015 Feb;52:200-11. PMID: 25486577
  20. Savitz J, Drevets WC, Smith CM, Victor TA, Wurfel BE, Bellgowan PS, Bodurka J, Teague TK, Dantzer R. Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder.Neuropsychopharmacology. 2015 Jan;40(2):463-71. PMID: 25074636
  21. Duffy FD, Miller-Cribbs JE, Clancy GP, Van De Wiele CJ, Teague TK, Crow S, Kollaja EA, Fox MD. Changing the culture of a medical school by orienting students and faculty toward community medicine. Acad Med. 2014 Dec;89(12):1630-5. PMID: 25162616.
  22. Singh R, Meier TB, Kuplicki R, Savitz J, Mukai I, Cavanagh L, Allen T, Teague TK, Nerio C, Polanski D, Bellgowan PS. Relationship of collegiate football experience and concussion with hippocampal volume and cognitive outcomes. JAMA. 2014 May 14;311(18):1883-8. PMID: 24825643.
  23. Savitz J, Frank MB, Victor T, Bebak M, Marino JH, Bellgowan PS, McKinney BA, Bodurka J, Kent Teague T, Drevets WC. Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain Behav Immun. 2013 Jul;31:161-71. PMID: 23064081
  24. Savitz J, Preskorn S, Teague TK, Drevets D, Yates W, Drevets W. Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2x2 clinical trial. BMJ Open. 2012 Feb 22;2(1):e000643. PMID: 22357572
  25. Tan C, Taylor AA, Coburn MZ, Marino JH, Van De Wiele CJ, Teague TK. Ten-color flow cytometry reveals distinct patterns of expression of CD124 and CD126 by developing thymocytes. BMC Immunol. 2011 Jun 20;12:36. PMID:
  26. Li X, Naylor MF, Le H, Nordquist RE, Teague TK, Howard CA, Murray C, Chen WR. Clinical effects of in situ photoimmunotherapy on late-stage melanoma patients: a preliminary study. Cancer Biol Ther. 2010 Dec 1;10(11):1081-7.  PMID: 20890121
  27. Teague TK, Tan C, Marino JH, Davis BK, Taylor AA, Huey RW, Van De Wiele CJ. CD28 expression redefines thymocyte development during the pre-T to DP transition. Int Immunol. 2010 May;22(5):387-97. PMID: 20203098.
  28. Marino JH, Tan C, Taylor AA, Bentley C, Van De Wiele CJ, Ranne R, Paliotta M, Broughan TA, Teague TK. Differential IL-7 responses in developing human thymocytes. Hum Immunol. 2010 Apr;71(4):329-33. PMID: 20074604
  29. Marino JH, Tan C, Davis B, Han ES, Hickey M, Naukam R, Taylor A, Miller KS, Van De Wiele CJ, Teague TK. Disruption of thymopoiesis in ST6Gal I-deficient mice. Glycobiology. 2008 Sep;18(9):719-26. PMID: 18535087
  30. Broughan TA, Naukam R, Tan C, Van De Wiele CJ, Refai H, Teague TK. Effects of hepatic zonal oxygen levels on hepatocyte stress responses. J Surg Res. 2008 Mar;145(1):150-60. PMID: 18164035.
  31. Van de Wiele CJ, Marino JH, Tan C, Kneale HA, Weber J, Morelli JN, Davis BK, Taylor AA, Teague TK. Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Cell Immunol. 2007 Nov-Dec;250(1-2):31-9. PMID: 18321477
  32. Naylor MF, Chen WR, Teague TK, Perry LA, Nordquist RE. In situ photoimmunotherapy: a tumour-directed treatment for melanoma. Br J Dermatol. 2006 Dec;155(6):1287-92. PMID: 17107404.
  33. Marino JH, Van De Wiele CJ, Everhart JM, Masengale R, Naukam RJ, Schniederjan MJ, Vo S, Teague TK. Attenuation of cytokine responsiveness during T cell development and differentiation. J Interferon Cytokine Res. 2006 Oct;26(10):748-59. PMID: 17032169.
  34. Rao RS, Howard CA, Teague TK. Pulmonary endothelial permeability is increased by fluid from packed red blood cell units but not by fluid from clinically-available washed units. J Trauma. 2006 Apr;60(4):851-8. PMID: 16612308.
  35. Van De Wiele CJ, Marino JH, Murray BW, Vo SS, Whetsell ME, Teague TK. Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J Immunol. 2004 Apr 1;172(7):4235-44. PMID: 15034036.
  36. Van De Wiele CJ, Marino JH, Whetsell ME, Vo SS, Masengale RM, Teague TK. Loss of interferon-induced Stat1 phosphorylation in activated T cells. J Interferon Cytokine Res. 2004 Mar;24(3):169-78. PMID: 15035850.
  37. Naylor MF, Crowson N, Kuwahara R, Teague K, Garcia C, Mackinnis C, Haque R, Odom C, Jankey C, Cornelison RL. Treatment of lentigo maligna with topical imiquimod. Br J Dermatol. 2003 Nov;149 Suppl 66:66-70. PMID: 14616356.

 

Flow Cytometry and Cell Sorting

Certified flow cytometrists: Ashlee Rempel, B.S., M.B.A. and Chibing Tan, Ph.D.

For instrument availability or laboratory protocol information contact:
Ashlee Rempel, B.S., M.B.A.
Phone: 918-660-3924
Fax: 918-660-3928
Email: ashlee-rempel@ouhsc.edu

 

Specialized Equipment:

LSR II

LSR-II “Special Order System” 4 laser flow cytometer. (Becton Dickinson)  This instrument is capable of 12-color detection and is equipped with solid state blue, green, red, and violet lasers.  It has a PC workstation including FACSDiva 6.0 software for analysis and data acquisition.

cell sorter

MoFlo XDP High speed cell sorting cytometer.  (Beckman Coulter/Cytomation)  This instrument is equipped with up to 8-color detection and 4-way sorting.  It has a PC workstation including Summit v5.0 acquisition and analysis software.

AutoMACS cell sorter (Miltenyi Biotec) This instrument is used for magnetic bead cell enrichment and is used to quickly enrich cells from very large starting populations.

Molecular Biology and Biomarker Analysis

For laboratory protocol information contact:
Julie Marino, PhD
Phone: 918-660-3934
Fax: 918-660-3928
Email: julie-marino@ouhsc.edu

Specialized Equipment:

PCR machine

ViiA7 Real-Time PCR System (Life Technologies) This is a high-throughput quantitative PCR instrument capable of rapid, high volume PCR analyses.  It is the ideal instrument for gene expression studies using the RNA biobanked during this study.

MESO QUICKPLEX SQ 120 (Meso Scale Discovery) is an instrument  that uses technology similar to plate-bound ELISAs but is specifically designed for high-sensitivity multiplexed assays.  This instrument allows for highly sensitive analysis of cytokines and other biomarkers using small sample sizes and low inter-assay variability.

SmartCycler Real-Time PCR machine (Cepheid) This instrument has 3 separate units and can analyze 48 samples independently using up to four fluorochromes simultaneously.  

ImageQuant LAS4000 (GE) This hardware/software package allows for image capture and analysis of Western blots, DNA and PCR gels, culture dishes and microscope fields.

Tissue Processing and Biobanking

For laboratory protocol information contact:
Brenda Davis, PhD
Phone: 918-660-3910
Fax: 918-660-3928
Email: brenda-davis@ouhsc.edu

 

tissue culture

 

 

cryostorage

 

 

cryostorage

P20GM131212-01 (Paulus) 09/15/2017 – 06/30/2022

NIH/NIGMS

The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) – The IIC serves as a core biomarker laboratory for the research projects and interventions for this multicenter project.

 

P20GM109097 sub #6025 (Teague) 07/01/2016 – 03/31/2021

NIH/NIGMS

Center for Integrative Research on Childhood Adversity (previously the Children's Health Equity Solutions Center) –The IIC serves as the biomarker core laboratories for the research projects and interventions for this multicenter project.

 

1R21MH113871-01A1 (Savitz) 08/01/2018 – 07/31/2020

NIH/NIMH

Acute modulation of neural circuitry regulating immune function in depression – The IIC is assessing innate and adaptive immune responses in patients with depression

 

NARSAD (Savitz) 09/01/2018 – 07/31/2019

Brain and Behavior Research Foundation

Impaired Adaptive Immunity in Depression. - The role of the IIC in this multicenter project is to assess inflammatory cytokines and other immune cell responses in patients with clinical depression.

 

COMAA (Price) 09/01/2017 – 07/31/2019

Recurrent Urinary Tract Infections and Heparin: a double-blind randomized clinical trial (RUTIH Trial) – The IIC role in this project is to analyze biomarkers in samples from patients suffering from recurrent bladder infections.

 

1R21NS099789-01A1 (Meier) 07/01/2017 – 06/30/2019

NIH/NINDS

Inflammation and Kynurenine Metabolites in the Acute Sequelae of Concussion – The IIC is designing and performing assessments of inflammatory markers in peripheral blood of athletes pre- and post- concussions.

 

HR16-003 (Miller) 08/01/2016 – 07/31/2019

Oklahoma Center for the Advancement of Science and Technology (OCAST)

The role of glutamatergic sensory neurons in the initiation of and response to colitis. – The IIC is providing expertise and flow cytometry instrumentation for the inflammation assays in this study.

 

Your gift to the Integrative Immunology Center will support the efforts of students, staff, and faculty who are researching the involvement of immune system factors in human diseases. All donations are tax-deductible.

Click here to donate to the Tulsa Immunology Research Program.