Kevin Snead

Major Professor: Bourne
Email: kevin.snead@ou.edu

Hometown:
Maryville, MO

High School:
Maryville High School

Education:
B.S., Chemistry with Biochemistry Emphasis, Northwest Missouri State University

I don't remember what initially sparked my interest in biochemistry, but I remember that I've wanted to study biochemistry since middle school.

I work with Dr. Christina Bourne and my research focuses on using biochemistry and structural biology to understand the protein-protein interactions found in type-II toxin-antitoxin systems, with a hope of identifying ways to disrupt these interactions in order to co-op these systems as new means for controlling bacterial cell growth.

After graduation, my plan is to go into industry to do structure-based drug design.

Publications, Presentations & Awards

Publications

ParD Antitoxin Hotspot Alters a Disorder-to-Order Transition upon Binding to Its Cognate ParE Toxin, Lessening Its Interaction Affinity and Increasing Its Protease Degradation Kinetics. Kevin J. Snead, Landon L. Moore, and Christina R. Bourne Biochemistry 2022 61 (1), 34-45 DOI: 10.1021/acs.biochem.1c00584
Intrinsic Degradation of the Type-II Antitoxin ParD from Pseudomonas aeruginosa. Kevin J. Snead, Christina R. Bourne bioRxiv 2021.03.29.437564; doi: https://doi.org/10.1101/2021.03.29.437564

Presentations

Great Plains Infectious Disease 2018: Kevin J. Snead, Tamiko Murphy, and Christina R. Bourne. Developing Strategies to Interrupt the Protein-Protein Interaction Interfaces of Type II Toxin-Antitoxin Systems (Poster). November 2018. 17th Annual Great Plains Infectious Disease Meeting. Lawrence, KS
University of Oklahoma Symposium on Structural Biology 2019: Kevin J. Snead, and Christina R. Bourne. Mechanistic Study of the Protein-Protein Interaction of a Type-II Toxin-Antitoxin System from Pseudomonas aeruginosa (Poster). June 2019. 7th Annual Symposium on Structural Biology. Norman, OK.
Great Plains Infectious Disease 2019: Kevin J. Snead, and Christina R. Bourne. Mechanistic Study of the Protein-Protein Interaction of a Type-II Toxin-Antitoxin System from Pseudomonas aeruginosa (Poster). November 2019. 18th Annual Great Plains Infectious Disease Meeting. Columbia, MO.
American Society of Microbiology Regional Meeting 2020 (Cancelled by Covid-19): Kevin J. Snead, and Christina R. Bourne. Mechanistic Study of the Protein-Protein Interaction of a Type-II Toxin-Antitoxin System from Pseudomonas aeruginosa (Poster). March 2020. Joint Meeting of the Missouri and Missouri Valley Branches of the American Society of Microbiology. Columbia, MO.
American Society of Microbiology Regional Meeting 2021: Kevin J. Snead, and Christina R. Bourne. Artificial Activation of a Type-II Toxin-Antitoxin System from Pseudomonas aeruginosa (Poster). March 2021. Joint Meeting of the Missouri and Missouri Valley Branches of the American Society of Microbiology. Online.
OCRID 8th Annual Research Symposium 2021: Kevin J. Snead, and Christina R. Bourne. Artificial Activation of a Type-II Toxin-Antitoxin System from Pseudomonas aeruginosa (Oral/Poster). April 2021. Oklahoma Center for Respiratory and Infectious Diseases. Online.
American Society of Microbiology Regional Meeting 2022: Kevin J. Snead, and Christina R. Bourne. Altering a TA System Protein-Protein Interface to Manipulate Bacterial Cell Growth (Poster). March 2022. Meeting of the Missouri Valley Branch of the American Society of Microbiology. Stillwater, OK.
University of Oklahoma Symposium on Structural Biology 2022: Kevin J. Snead, Felipe Ferreira, and Christina R. Bourne. Disrupting a TA System Protein-Protein Interaction to Manipulate Bacterial Cell Growth (Poster). June 2022. 10th Annual Symposium on Structural Biology. Norman, OK.

Awards

Graduate Research Scholarship in X-ray Based Structural Biology (2018)