Yanting Guo

Major Professor: Wu
Email: yantingguo@ou.edu

Hometown:
Hebei Province, China

Education:
Bachelor at Nanjing University of Science and Technology

Yanting Guo received her bachelor’s degree at the Nanjing University of Science and Technology at the major of Biochemistry and biotechnology, where she started her biochemistry journey. She is currently a Ph.D student in the Department of Chemistry and Biochemistry at University of Oklahoma. Her research in Dr. Si Wu’s research lab focuses on mass spectrometry-based quantitative top-down proteomics method development and application. Specifically, she developed and optimized protein-level tandem mass tag (TMT) labeling for quantitation in complex biological samples using top-down proteomics with 1D or 2D ultra-pressure liquid chromatography (UPLC). After graduation, she would like to work in pharmaceutical company to work on drug development and protein-related researches.

Publications, Patents & Presentations

Publications & Patents

Yanting Guo, Trishika Chowdhury, Meena Seshadri, Kellye A. Cupp-Sutton, Qingyu Wang, Dahang Yu, Si Wu. Optimization of Higher-Energy Collisional Dissociation Fragmentation Energy for Intact Protein-level Tandem Mass Tag Labeling. (Manuscript in revision)
Yanting Guo, Dahang Yu, Kellye A. Cupp-Sutton, Xiaowen Liu, Si Wu. A Benchmarking Protocol for Optimized Protein-Level Tandem Mass Tag (TMT) Labeling for Quantitative Top-Down Proteomics. MethodX, 2022: 101873.
Yanting Guo*, Dahang Yu*, Kellye A. Cupp-Sutton, Xiaowen Liu, Si Wu. Optimization of Protein-Level Tandem Mass Tag (TMT) Labeling in Complex Sample with Top-Down Proteomics. Analytica Chimica Acta, 2022, 340037.
Yanting Guo*, Xing Chen*, Xuan Zhang, Shujin Pu, Xutong Zhang, Chengli Yang, Dali Li. Comparative studies on ZIF-8 and SiO₂ nanoparticles as carrier for immobilized β-glucosidase. Molecular Catalysis, 2018, 459: 1-7.
Yu, Dahang, Zhe Wang, Kellye A. Cupp-Sutton, Yanting Guo, Qiang Kou, Kenneth Smith, Xiaowen Liu, and Si Wu. "Quantitative top-down proteomics in complex samples using protein-level tandem mass tag labeling." Journal of the American Society for Mass Spectrometry 32, no. 6 (2021): 1336-1344. (Supplementary journal cover)
Tra D Nguyen*, Mahbobeh Lesani*, Ines Forrest*, Yunpeng Lan*, Danya A Dean, Quentin MR Gibaut, Yanting Guo, Ekram Hossain, Marcela Olvera, Hannah Panlilio, Adwaita R Parab, Chaoyi Wu, Jean A Bernatchez, Robert H Cichewicz, Laura-Isobel McCall. Local phenomena shape backyard soil metabolite composition. Metabolites, 2020, 10(3): 86.
Sidra Naseer, Jie Ouyang, Xing Chen, Shujin Pu, Yanting Guo, Xuan Zhang, Dali Li, Chengli Yang. Immobilization of β-glucosidase by self-catalysis and compared to crosslinking with glutaraldehyde. International journal of biological macromolecules, 2020, 154: 1490-1495
Jun Yi, Mulin Fang, Yanting Guo, Jie Liang Yuxian Dai, Zhan Ren, Mengyu Li, Hongtao Li, Daiwei Liao. The practical new-type patent of A New Intelligent Three-phase Air Purifier (Patent No. CN206449746U)

Selected Presentations

(20 additional involved presentations)

Yanting Guo, Zhe Wang, Dahang Yu, Kellye A Cupp-Sutton, and Si Wu. Development of a novel drug target identification platform based on size (DTIPS). 67^th ASMS Conference on Mass Spectrometry and Allied Topics, June 2- June 6, 2019 (Oral presentation)
Yanting Guo, Zhe Wang, Dahang Yu, Kellye A Cupp-Sutton, and Si Wu. Development of a novel drug target identification platform based on size (DTIPS). 2019 Designing Molecules and Workshop Conference. Kansas State University, Manhattan, KS, August 15-17, 2019 (Poster presentation)
Yanting Guo, Dahang Yu, Kellye A. Cupp-Sutton, Xiaowen Liu, Si Wu. Optimization of Protein-Level Tandem Mass Tag (TMT) Labeling in Complex Sample with Top-Down Proteomics. 17th USHUPO Virtual Annual Conference, March 3-8, 2021 (Poster and oral presentation)
Yanting Guo, Dahang Yu, Kellye A. Cupp-Sutton, Xiaowen Liu, Si Wu. Optimization of Quantitative Top-Down Proteomics in Complex Samples using Protein-Level Tandem Mass Tag (TMT) Labeling. 1st CASMS, August 9-13, 2021 (Poster and oral presentation, Best Poster award)
Yanting Guo, Kellye A. Cupp-Sutton, Dahang Yu, Walter P. Galie, Kenneth Smith, Xiaowen Liu, Si Wu. Quantitative Analysis of Intact Plasma Proteome in Systematic Lupus Erythematosus (SLE) using protein-level TMT labeling and top-down proteomics. 69^th ASMS Conference on Mass Spectrometry and Allied Topics, October 31- November 4, 2021 (Poster and oral presentation)
Yanting Guo, Kellye A. Cupp-Sutton, Dahang Yu, Walter P. Galie, Ken Smith, Xiaowen Liu, Si Wu. Quantitative analysis of Intact Plasma Proteome in Systematic Lupus Erythematosus (SLE) using Protein-Level TMT Labeling and Top-Down Proteomics. US HUPO 2022 One World, February 26 – March 2, 2022 (Poster and oral presentation)
Yanting Guo, Kellye A. Cupp-Sutton, Si Wu. Top-down Proteomics for PTM Characterization. US HUPO 2022 One World, February 26 – March 2, 2022 (Short course oral presentation)
Yanting Guo, Kellye A. Cupp-Sutton, Dahang Yu, Walter P. Galie, Ken Smith, Xiaowen Liu, Si Wu. Investigation of Systematic Lupus Erythematosus (SLE) Biomarkers using Top-down TMT Labeling and Two-Dimensional High-pH/Low-pH Reversed Phase Liquid Chromatography Separation. 70^th ASMS Conference on Mass Spectrometry and Allied Topics, June 5-9, 2022 (Poster presentation)
Yanting Guo, Kellye A. Cupp-Sutton, Dahang Yu, Walter P. Galie, Meena Seshadri, Qingyu Wang, Ken Smith, Xiaowen Liu, Si Wu. Investigation of Systematic Lupus Erythematosus (SLE) Biomarkers using Protein-Level TMT Labeling and Top-Down Online Two-Dimensional High-pH/Low-pH RPLC-MS Analysis. 2^nd CASMS, October 17-21, 2022 (Poster presentation)