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Lee Krumholz, PhD

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Lee Krumholz, Ph.D.

Professor of Microbiology

616 George Lynn Cross Hall
770 Van Vleet Oval
Norman, OK 73019
405-325-0437 (Office)
405-325-5255 (Lab)

B.S. University of Guelph 1982
M.S. University of Illinois 1985. Ph.D. 1988.
Postdoc, Stanford 1988-1990

Research areas:
Microbiology, Molecular and Cellular Biology, Environmental Science, Ecology, Anaerobic Microbiology

Research interests:
My primary area of research focusses on microbial interactions in ecologically relevant systems.  The following are the funded projects on which my students and I are currently involved (1) Understanding carbon flow in methane oxidizing (methanotrophic) microbial communities and isolation of novel methane oxidizing bacteria. We are studying methanotrophy in a variety of systems including deep rock formations at Sanford Underground Research Facility, high temperature Yellowstone National Park and several methane rich sites in Oklahoma.  These studies use a combination of techniques including sequence analysis and cultivation of microorganisms. This project is currently funded through the National Science Foundation. (2) Toxic cyanobacterial blooms and their associated microbial communities.   This process harnesses our global bloom network to ask fundamental questions regarding the relative importance of commensal bacteria in bloom communities that are dominated by Microcystis sp. and to determine the role of these bacteria in the ecology of the bloom. This project uses both molecular ecology, genomics and more traditional ecology techniques to understand interactions of bacteria within the bloom. This project is also funded through a National Science Foundation grant.

Relevant publications:

Li, C., Hambright, K.D., Bowen, H.G., Trammell, M.A. Grossart, H.-P., Burford, M.A., Hamilton, D.P., Jiang, H.,  Latour, D., Meyer, E.I., Padisák, J.,  Zamor, R.M. and Lee R. Krumholz.  2021.  Global Co-occurrence of Methanogenic Archaea and Methanotrophic Bacteria in Microcystis Aggregates.  Environmental Microbiology.  23:6503-6519.

Chen, M., Jiao, Y.Y., Zhang, Y-Q., Krumholz, L.R., Ren, J-X., Li, Z-H., Zhao, L-Y., Song, H-T. and Jin-Deng Lu. 2020. Succession of sulfur bacteria during , decomposition of cyanobacterial bloom biomass in the shallow Lake Nanhu: An ex situ mesocosm study. Chemosphere. 256.

Cook, K.V., Li, C., Cai, H., Krumholz, L.R., Hambright, K.D., Paerl, H.W.,  Steffen, M.M., Wilson, A.E.,  Burford, M., Grossart,  H.-P.,  Hamilton, D. P., Jiang, H., Sukenik, A.,  Latour, D., Meyer, E., Padisák, J., Qin, B., Zamor, R.M. and G. Zhu.  2020.  The global Microcystis interactome.  Limnol. Oceanog. 65 (Suppl 1) S194–S207. Epub Nov. 2019. 

Yan, Z., Y. He, H. Cai, J. D. Van Nostrand, Z. He, J. Zhou, L.R. Krumholz, H.-L. Jiang.  2017.  Interconnection of Key Microbial Functional Genes for Enhanced Benzo[a]pyrene Biodegradation in Sediments by Microbial Electrochemistry.  Environmental Science and Technology 51: 8519-8529.  

Chen M, Li X-H, He Y-H, Song N, Cai H-Y, Wang C, Li Y-T, Chu H-Y, Krumholz LR, Jiang H. 2016.  Increasing sulfate concentrations result in higher sulfide production and phosphorous mobilization in a shallow eutrophic freshwater lake.  Water Research.  96:94-104. 

Wang L, Bradstock P, Li C, McInerney MJ, Krumholz LR. (2016) The role of Rnf in ion gradient formation in Desulfovibrio alaskensis. PeerJ 4:e1919

Spain AM, Elshahed MS, Najar FZ, and Krumholz LR. 2015. Metatranscriptomic analysis of a high-sulfide aquatic spring reveals insights into sulfur cycling and unexpected aerobic metabolism. PeerJ 3:e1259.

Krumholz, L.R.,  P. Bradstock, C.S. Sheik, Y. Diao, O. Gazioglu, Y. Gorby and M. J. McInerney. 2015.  Syntrophic growth of Desulfovibrio alaskensis requires genes for H2 and formate metabolism as well as those for flagellum and biofilm formation.  Appl. Environ. Microbiol. 81(7): 2339-2348.