J. Mikhail Kellawan
Associate Professor, Health and Exercise Science Human Circulation Research Laboratory, 1401 Asp AVE, Rm. 112 405-325-9028 kellawan at ou dot edu https://www.ou.edu/cas/hes/research/research-laboratories/human-circulation-research-lab Ph.D., Kinesiology & Health Studies - Queen’s University, CA, 2013RESEARCH:
Matching delivery of blood (thus, oxygen and other substrates) to tissue demand is a critical role of the cardiovascular system, such that, inability of structural and functional systems to properly support tissues affects exercise capacity, tolerance, functional activities of daily life, and promotes poor cardiovascular health outcomes. To ensure that blood flow matches metabolic demand, the cardiovascular system must maintain arterial blood pressure while constantly adjusting blood flow throughout all the vascular beds in the circulatory system. Exercise presents an exceptional challenge to the cardiovascular system, as working muscles need a dramatic increase in blood flow to deliver adequate amounts of oxygen. Therefore, integrated control of cardiac output (amount of blood pumped by the heart), vasodilation (opening of blood vessels) and vasoconstriction (narrowing of blood vessels) is needed to direct blood from non-working tissues to the working muscles without severely impacting blood flow to the brain. Recent research indicates that conditions that interfere with proper “matching” of blood flow to metabolic demand affect both physical and cognitive health. The Human Circulation Research Laboratory (HCRL) research focus is to conduct experiments that provide insight into the vascular control mechanisms in the cerebral and skeletal muscle circulations during exercise and environmental stress in humans.
Selected Publications:
Owens, C., Mukli, P., Csipo, T., Lipecz, A., Silva-Palacios, F., Dasari, T., Tarantini, S., Gardner, A., Montgomery, P., Waldstein, S., Kellawan, J. M., Nyul-Toth, A., Balasubramanian, P., Sotonyi, P., Csiszar, A., Ungvari, Z., and Yabluchanskiy, A. (2022) Peripheral artery disease exacerbates microvascular endothelial dysfunction and neurovascular uncoupling, contributing to cognitive decline in older adults. American Journal of Physiology: Heart and Circulatory Physiology 322: H924-H935.
Carter, K. J., Ward, A. T., Kellawan, J. M., Eldridge, M., Al-Subu, A., Walker, B., Lee, J. W., Wieben, O., and Schrage, W. G. (2021) Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion. Physiological Reports 8: e14622.
Ashley, J. D., Shelley, J. H., Sun, J., Song, J., Trent, J. A., Ambrosio, L. D., Larson, D. J., Larson, R. D., Yabluchanskiy, A., and Kellawan, J. M. (2020) Cerebrovascular responses to graded exercise in young healthy males and females. Physiological Reports 8: e14622.
Stone, B. L., Beneda-Bender, M., McCollum, D. L., Sun, J., Shelley, J. H., Ashley, J. D., Fuenzalida, E., and Kellawan, J. M. (2020) Understanding cognitive performance during exercise in Reserved Officers’ Training Corps: establishing the executive function-exercise intensity relationship. Journal of Applied Physiology 129: 846-854.
Gonzales, J. U., Fischer, S. M., Maharaj, A., Vellers, H., Anderson T., Karnjanapiboonwong A., Subbiah S., Kellawan, J. M., and Figueroa, A.(2020) Response of exercise‐onset vasodilator kinetics to L‐citrulline supplementation during different phases of the menstrual cycle. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 318: R468-R479.
Kellawan, J. M., Peltonen, G. L., Harrell, J. W., Roldan-Azate, A., Wieben, O., and Schrage, W. G. (2020) Differential contribution of cyclooxygenase to basal cerebral blood flow and hypoxic cerebral vasodilation. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 318: R468-R479.
Sun, J., Ashley, J., and Kellawan, J. M., (2019) Can Acupuncture Treatment of Hypertension Improve Brain Health? A Mini Review. Frontiers in Aging Neuroscience 11(240): 1-8.
Kellawan, J. M., Limberg, J. K., Scruggs, Z. M., Nicholson, W. T., Schrage, W. G., Joyner, M. J., and Curry, T. B. (2018) Phosphodiesterase-5 inhibition preserves exercise-onset vasodilator kinetics when NOS activity is reduced. Journal of Applied Physiology 124: 276–282. doi:10.1152/japplphysiol.00483.2017
Limberg, J. K., Malterer, K. R., Kellawan, J. M., Schrage, W. G., Wilkins, B. W., Nicholson, W. T., Eisenach, J. H., Joyner, M. J., and Curry, T. B. (2017) Potentiation of the NO-cGMP pathway and blood flow responses during dynamic exercise in healthy humans. European Journal of Applied Physiology 117(2): 237-246
Hoscheidt, S. M.*, Kellawan, J. M.*, Berman, S. E., Rivera-Rivera, L. A., Krause, R. A., Oh, J. M., Beeri, M. S., Rowley, H. A., Wieben, O., Carlsson, C. M., Asthana, S., Johnson, S. C., Schrage, W. G., and Bendlin, B. B. (2017) Insulin resistance is associated with lower arterial blood flow and reduced cortical perfusion in cognitively asymptomatic middle-aged adults. J Cereb Blood Flow Metab 37: 2249–2261. doi:10.1177/0271678X16663214 *Co-first authors