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Macromolecular Crystallography Laboratory

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Macromolecular Crystallography Laboratory (MCL)

The MCL provides all necessary resources for structure determination of macromolecules. Services range from conduction initial crystallization trials to single crystal x-ray diffraction and structure determination of macromolecular molecules (proteins and nucleic acids). We provide help and guidance from initial crystallization trials to a completed structure for internal and external research groups.

Services (fee based)

  • Crystallization of macromolecules
  • Production of optimization crystallization screens and trials
  • Single crystal X-ray diffraction data collection and processing for macromolecules 
  • Structure determination of macromolecules
  • Deposition of structural data
  • Training in all aspects of crystal growth, X-ray data collection, structure solution and refinement 

Instruments (fee based)

  • Rigaku MicroMax 007HF microfocus X-ray generator. 
  • Dectris Pilatus 200K silicon pixel detector mounted on a AFC11  4-axis  goniometer
  • Oxford Cryosystems Cryostream 700 Series is utilized for low temperature data collection 
  • Rigaku RAXIS IV++ image plate detector
  • Linux workstations using with current crystallographic software for data processing and structure determination.
  • LN2 dewars are available for long-term crystal storage
  • TTP Labtech Mosquito nanoliter liquid handler
  • Art Robbins Instruments Scorpion liquid handler
  • Formulatrix Rock Imager 1000 with UV and Multi Fluorescence Imaging capabilities 
  • Rigaku DT Minstrel Imager and plate hotel
  • Leica M205 with MC170HD digital camera
  • Various microscopes and tools for sample handling

Location

Contact

Leonard M. Thomas, Ph.D
Phone: 405-325-1126
Email: lmthomas@ou.edu

Address

Stephenson Life Sciences Research Center
101 Stephenson Parkway
Rm 2750
Norman, OK 73019