The Oklahoma COBRE in Structural Biology Phase 3 program provides support for research activities that will increase the number of researchers that utilize the COBRE-supported scientific core facilities. The projects that the OCSB will support typically combine structural biology approaches with other functional characterization of important biomolecules that are relevant to improving human health and will require equipment and services of the Biomolecular Structure Core and/or the Protein Production and Characterization Core.
Project Investigator, Dept. Biochemistry & Molecular Biology, OSU
Project Title: Revealing Substrate Recognition Mechanism of Human SAMD9 tRNase through Cryo-EM
Email: junpeng.deng@okstate.edu
Project Investigator, Microbiology & Molecular Genetics, OSU
Project Title: Structural Characterization of a Family of Bacterial Channel Transporter Proteins that is Exclusively Found in Pathogenic Mycobacteria
Email: avi.mitra@okstate.edu
CoPI: Christina Bourne (OU-Norman)
Project Investigator, School of Biological Sciences, OU-Norman
Project Title: Structural Characterization of Lap-like Proteins Required for Biofilm Formation and Gut Colonization by Desulfovibrio vulgaris Hildenborough
Email: deleonkb@ou.edu
CoPI: Christina Bourne
Project Investigator, Dept. of Chemistry & Biochemistry, OU-Norman
Project Title: Elucidating the Determinants of Catalytic Bias in NADH-Dependent Dehydrogenases
Email: jw.peters@ou.edu
CoPI: Florence Mus
Project Investigator, Dept. of Chemistry & Biochemistry, OU-Norman
Project Title: An Efficient Platform for SAM-Analog Generation and Utilization
Email: shanteri.singh@ou.edu
Project Investigator, Dept. of Pharmaceutical Sciences, OU Health Campus
Project Title: Structure/Function of Oxysterol-Binding Protein to Guide Therapeutic Development
Email: anthony-burgett@ouhsc.edu
CoPI: Christina Bourne
Project Investigator, Dept. of Microbiology and Molecular Genetics, OSU
Project Title: Determining the Structure-Function Relationship of Immune-Modulatory C. trachomatis Inc Protein CT226
Email: erika.lutter@okstate.edu
CoPI: Christina Bourne
Project Investigator, Dept. of Chemistry and Biochemistry, OU-Norman
Project Title: A Combined Computational and Experimental Study of CRISPR Cas9/12a Enzyme Reaction Mechanism
Email: yihan.shao@ou.edu
CoPI: Rakhi Rajan
Project Investigator, Dept. of Biological Sciences, SWOSU
Project Title: Structural and Functional Characterization of Proteins Essential for Metabolism and Virulence in Streptococcus sanguinis
Email: vijay.somalinga@swosu.edu
CoPI: Rakhi Rajan
Project Investigator, Dept. of Microbiology and Molecular Genetics, OSU
Project Title: Bax Pore Formation in Apoptosis: Structures of Intermediates and Mechanism of Assembly
Email: jialing-lin@ouhsc.edu
Project Investigator, Dept. of Cell Biology, OUHSC
Project Title: Development of Methyl Dichlorocarbonyl Compounds for Specific RALDH2 Inhibition
Email: jody-summers@ouhsc.edu
Junior Investigator, Dept. of Biology, OU-Norman
Project Title: Scorpion Peptides That Inhibit a Transmembrane Sodium Ion Channel (Nav1.8) Regulator of Pain-Sensing Neurons: Structural Characterization of the Peptide-Nav1.8 Complex
Email: ahrowe@ou.edu
Junior Investigator, Dept. of Chemistry & Biochemistry, OU-Norman
Funding: NIH 1R01GM138800
Project Title: Development of Chemoenzymatic Platform for Facile Synthesis of Alkyl-Pyrophosphate Analogs
Email: shanteri.singh@ou.edu
Pilot Project Leader, Dept. of Physiology, OU Health Campus
Project Title: Preparation of Tetraspanin Proteins for Structure and Function Studies
Email: xin-zhang-1@ouhsc.edu
Junior Investigator, Department of Medicinal Chemistry, University of Minnesota
Project Title: Structure, Function and Therapeutic Potential of Clostridium difficile Caseinolytic Protease P
Email: aduerfel@umn.edu
Pilot Project Leader, Dept. of Cell Biology, OU Health Campus
Project Title: Enabling JMJD4 Inhibitor Development Through Structural Studies
Email: ralf-janknecht@ouhsc.edu
Pilot Project Leader, Dept. of Biochemistry & Molecular Biology, OU Health Campus
Project Title: Munc18 Mutations in Synaptic Transmission, Epileptic Seizures and Dementia
Email: fdeak@augusta.edu
Pilot Project Investigator, Dept. of Pathology, OU Health Campus
Project Titles: (1) Effects of Arginine Methylation on SRSF1-miRNA Binding and (2) The Structural Basis of SRSF1 Recognition of miRNA Sequence Motifs
Email: weiqun-ding@ouhsc.edu
CoPI: Blaine Mooers
Pilot Project Leader, Dept. of Biochemistry & Molecular Biology, Oklahoma State University
Project Title: Co-crystallization of TRAP1 with Inhibitors for Enhancement of Structure-based Drug Design
Email: robert.matts@okstate.edu
Junior Investigator, Department of Chemistry & Biochemistry, OU-Norman
Project Title: Mechanistic Studies of CRISPR-Mediated Bacterial Immunity
Email: r-rajan@ou.edu
Pilot Project Leader, Dept. of Chemistry and Biochemistry, OU-Norman
Project Title: Multiscale Free Energy Simulation of Enzymatic Reactions
Email: yihan.shao@ou.edu
Junior Project Leader, Dept. of Pharmaceutical Sciences, OU Health Campus
Project Title: Structural Approach to Define New Functional Activities of Neutrophil Protein CAP37 in Neurodegenerative Diseases
Email: anne-kasus-jacobi@ouhsc.edu
Junior Investigator, Department of Chemistry & Biochemistry, OU-Norman
Project Title: Probing the Potential of the Gyrase Inhibitor ParE for Antibacterial Applications
Email: cbourne@ou.edu
Pilot Project Leader, Dept. of Chemistry & Biochemistry, OU-Norman
Project Title: Structure-Based Design of Potent and Selective Inhibitors to Pro-Apoptotic Bax/Bak
Email: isharma@ou.edu
Junior Investigator, Dept. of Microbiology & Plant Biology, OU-Norman
Project Title: Structure-Function Studies of MsvR, a Methanogen-Specific Transcriptional Regulator
Email: lizkarr@ou.edu
Project Investigator, Dept. of Cell Biology, OU Health Campus
Project Title: Structural Characterization of Gamma-Glutamyl Transferase Enzymes
Email: marie-hanigan@ouhsc.edu
Junior Investigator, Dept. of Chemistry & Biochemistry, OU-Norman
Funding: NSF-REU 1359457
Project Title: Structural and Mechanistic Studies of Essential Microbial Kinases
Email: psims@ou.edu
Pilot Project Investigator, Dept. of Pharmaceutical Sciences, OU Health Campus
Funding: NIH P20GM103648
Project Title: Structure-Function Relation of a TLR4-Interacting Surfactant Protein A-Derived Peptide
Email: shanjana-awasthi@ouhsc.edu
Pilot Project Investigator, Nebraska Center for Virology, U. of Nebraska-Lincoln
Project Title: Allele-Specific mRNA Structures in the Regulation of MMTV Gag Translation
Email: jwest2@unl.edu
Junior Investigator, Dept. of Biochemistry & Molecular Biology, OU Health Campus
Funding: NIH 1R01GM104251
Project Title: RAMP-altered Class B GPCR Hormone Recognition
Email: augen-pioszak@ouhsc.edu
Pilot Project Investigator, Dept. of Pharmaceutical Sciences, OU Health Campus
Funding: NIH 1R01 AI088011
Project Title: The Role of Non-Canonical Base Pairs in RNA Editing
Email: blaine-mooers@ouhsc.edu
Junior Investigator, Dept. of Pharmaceutical Sciences, U. Maryland
Funding: NIH 1R01GM098818
Project Title: Electrostatic Modulation of Protein Stability and Folding
Email: jshen@rx.umaryland.edu
