The human genome and the genomic inventory of the microflora that human life depends on are complete yet the essence of how commensal E.coli colonizes the intestine is not understood. In this NIH-funded laboratory, researchers use DNA microarrays and genetics to unravel the carbon nutrition of E. coli colonized in the mouse intestine. It has recently been shown that gastrointestinal pathogens are able to infect healthy individuals by competing for a different set of nutrients than do the harmless members of our normal commensal microbiota.
Dr. Tyrrell Conway
Dr. Yiqi Luo
Professor of Ecology. Dr. Luo’s research program is designed to study processes and patterns in ecosystem ecology and biogeochemical cycles. Major issues we are addressing include (1) how global environmental changes alter function and structure of terrestrial ecosystems, and (2) how terrestrial ecosystems regulates climate change and chemical composition (such as CO2) in the atmosphere. Our research is aimed at quantifying dynamics of carbon, nutrient, and water resources in ecosystems. We study a variety of ecosystems, including forests, grasslands, deserts, and coastal wetlands.Our laboratory uses both modeling and experimental approaches. With respect of modeling, we focus on development and testing of biogeochemical models at ecosystem and regional scales. Our current efforts are on development of an inverse modeling approach to parameter estimation and model improvement. Our inverse modeling uses data from the Free-Air CO2 Enrichment (FACE) experiment in the Duke Forest, AmeriFlux sites and biometrical measurements.
Dr. Bruce Roe
The Advanced Center for Genome Technology (ACGT) at the University of Oklahoma's Chemistry Department has been a designated Genome Center by the National Institutes of Health, National Human Genome Research Institute (NIH-NHGRI) since 1990 and is one of the first three laboratories involved in the world-wide Human Genome Project. Since then the ACGT has mapped (sequenced) the first completed human chromosome, human chromosome 22, discovering the genes involved in several forms of mental retardation, brain cancer, leukemia and schizophrenia. ACGT's research presently is funded by grants from the National Institutes of Health, National Human Genome Research Institute, National Science Foundation, Department of Energy, US Department of Agriculture and the Noble Foundation.
Dr. David Schmidtke
Dr. Schmidtke's research interests are in the design and development of new analytical devices and technologies for medical therapy, and lie at the interface of medicine and engineering. His current research can be divided into three research directions: 1. Cell Adhesion; 2. Microfabrication; and 3. Biosensors