Linda Lieu

Major Professor: Fornelli
Email: lindablieu@ou.edu

Hometown:
Oklahoma City, OK

High School:
Putnam City High School

Education:
B.S., Biology, University of Oklahoma
Minor, Chemistry, University of Oklahoma

I have always been interested in understanding how biological processes worked. Chemistry and biochemistry are fields in which explore these processes, so I focused my interests there.

My plans post grad are to join a biopharmaceutical company in the industry field.

Publications, Presentations & Awards

Publications

Oates, R. N.*, Lieu, L. B.*, Srzentić, K., Damoc, E. & Fornelli, L. Characterization of a Monoclonal Antibody by Native and Denaturing Top-Down Mass Spectrometry. J Am Soc Mass Spectrom 2024. https://doi.org/10.1021/jasms.4c00224
Lieu, L. B.; Nagy, C.; Huang, J.; Mullen, C.; McAlister, G. C.; Zabrouskov, V.; Srzentić, K.; Durbin, K. R.; Melani, R. D.; Fornelli, L. Enhanced Payload Localization in Antibody–Drug Conjugates Using a Middle-Down Mass Spectrometry Approach with Proton Transfer Charge Reduction. Anal Chem 2024. https://doi.org/10.1021/acs.analchem.4c03872.
Lieu, L. B.; Hinkle, J. D.; Syka, J. E. P.; Fornelli, L. Leveraging Ion–Ion and Ion–Photon Activation to Improve the Sequencing of Proteins Carrying Multiple Disulfide Bonds: The Human Serum Albumin Case Study. J Am Soc Mass Spectrom 2024. https://doi.org/10.1021/jasms.4c00391.
Oates, R. N.; Lieu, L. B.; Kline, J. T.; Mullen, C.; Srzentić, K.; Huguet, R.; McAlister, G. C.; Huang, J.; Bergen, D.; Melani, R. D.; Zabrouskov, V.; Durbin, K. R.; Syka, J. E. P.; Fornelli, L. Towards a Universal Method for Middle-down Analysis of Antibodies via Proton Transfer Charge Reduction—Orbitrap Mass Spectrometry. Anal Bioanal Chem 2024. https://doi.org/10.1007/s00216-024-05534-z.
Kline, J. T.; Huang, J.; Lieu, L. B.; Srzentić, K.; Bergen, D.; Mullen, C.; McAlister, G. C.; Durbin, K. R.; Melani, R. D.; Fornelli, L. Top‐down Mass Spectrometry Analysis of Capsid Proteins of Recombinant Adeno‐associated Virus Using Multiple Ion Activations and Proton Transfer Charge Reduction. Proteomics 2024. https://doi.org/10.1002/pmic.202400223.

Presentations

Lieu, L.B., Hinkle, J., Syka, J.E.P., Fornelli, L. Leveraging ion-ion and ion-photon reactions to improve the sequencing of proteins carrying multiple disulfide bonds: the human serum albumin case study. ASMS Annual Meeting; 2023 June; Houston, TX. [poster presenter]
Lieu, L.B., Nagy C., Huang, J., Mullen, C., McAlister, G., Bergen, D., Zabrouskov, V., Srzentic, K., Durbin, K., Melani, R., Fornelli, L. Enhancing drug-payload localization in antibody-drug conjugates with a middle-down approach using proton transfer charge reduction on a modified Orbitrap Ascend. ASMS Annual Meeting; 2024 June; Anaheim, CA. [poster presenter]
Lieu, L.B., Nagy C., Huang, J., Mullen, C., McAlister, G., Bergen, D., Zabrouskov, V., Srzentic, K., Durbin, K., Melani, R., Fornelli, L. Middle-down Approach Using Proton Transfer Charge Reduction Enables Unambiguous Drug-Payload Localization in Cys-linked Antibody Drug Conjugates. Mass Spectrometry Symposium CASSS; 2024 September; Rockville, MD. [oral presenter]
Lieu, L.B., Hinkle, J., Huang, J., Melani, R., J. E.P., Syka, Fornelli, L. (2025). Utilizing ion-ion and ion-photon activation for the enhanced middle-down characterization of antibody-based therapeutics. 73rd ASMS conference, Baltimore, MD. [oral presenter]
Lieu, L.B., Carfagno, A., Durbin, K., Fornelli, L. (2025). Enhancing the Localization of Forced Oxidative Products in mAb-Based Therapeutics Using Proton Transfer Charge Reduction. 35th Winter Conference on Mass Spectrometry, Santa Fe, NM. [oral presenter]

Awards

Next Generation Investigator Award, CASSS Mass Spec Symposium, 2024
Dodge Family College of Arts and Sciences Travel Award, 2025
ACS Division of Analytical Chemistry Graduate Honorable Mention, 2025
ASMS Student Travel Grant, 2025