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Mass Spectrometry, Proteomics & Metabolomics (MSPM) Core

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University of Oklahoma Mass Spectrometry, Proteomics & Metabolomics (MSPM) Core

Welcome to the University of Oklahoma Mass Spectrometry, Proteomics & Metabolomics (MSPM)Core Facility. We are located in the Department of Chemistry and Biochemistry in the Stephenson Life Sciences Research Center on the Research Campus in South Norman.

The OU MSPM Core Facility operates, maintains and services numerous mass spectrometers and ultra-high-pressure liquid chromatographs (UHPLC). The facility provides a broad range of services including: for-fee sample analysis, user-run open-access instrumentation, teaching, education, consulting, and collaborative research projects.


Diagram depicting all the ways Mass Spectrometry can be used



UHPLC / Q-TOF MS (2016)

Consists of an Agilent 6545 high-mass-resolution Q-TOF mass spectrometer and an Agilent 1290 UPLC (1200 bar). The Mass Hunter data-control system includes qualitative and quantitative analysis as well as advanced metabolomics software, Mass Profiler Pro. The ultra-high mass resolution and UPLC allows for the separation of more than 1,000 compounds in a single LC/MS run. This system includes Agilent Rapid Fire 365 high-throughput automated sample prep robotics. Applications: Metabolomics

Agilent Instrument
Rapid Fire Instrument

UHPLC / Ion Mobility / Q-TOF MS (2017)

Comprised of a Waters SYNAPT G2-Si Q-TOF/MS and a Waters M-Class chromatography system that can be set up as micro-flow UHPLC or nano-LC. With the new technology of high-efficiency T-Wave ion mobility, we can obtain an additional dimension of separation based on molecular size and shape. The wide range of benefits feature: isomer separation, elimination of interferences, generation of cleaner spectra and the ability to better confirm compound ID. Applications: Metabolomics and Proteomics

Bonifay working instrument
Photo of Waters Instrument

Orbitrap High-Resolution MS (2020)

The Thermo Scientific Orbitrap HF-X Hybrid MS with nano UHPLC excels at the most challenging proteomic applications, including high-throughput bottom-up (peptide-based) protein identification, low-abundant PTM analysis, label-free quantitation, and intact protein characterization. Applications: Proteomics

Photo of Orbitrap High-Resolution MS (2020)

ICP MS with Laser Ablation (2018)

PerkinElmer NexION2000 Inductively Coupled Plasma (ICP)-MS with Single Cell analysis capability, Elemental Scientific Inc (ESI) - New Wave Research 213 nm Laser Ablation system and ESI prepFAST IC automation with integrated autosampler and LC capability. This system is ideal for analysis of metals in soil, rock surface, bird feathers, bones, plants and single cell biomedical applications. Applications: Elemental Trace Metals


Photo of PE ICP Instrument

(2) GC / quadrupole MS (2018 & 2019)

Agilent 6890N gas chromatograph (GC) with an Agilent 5973 Mass Selective Detector (MSD) and electron impact (EI) ion source. This is specific for volatile compounds and gases from 20-600 mass, notably benzenes, alcohols and aromatics. It is often used in toxicology, pesticide analysis and the oil & gas industry. Applications: Volatile Molecules

Photo of Agilent 6890N gas chromatograph

More Details Coming Soon - This Site is Under Construction

Miscellaneous Support Instruments:

a. Leitz Wetzlar SM-LUX Binocular Head Laboratory Microscope includes transmitted and reflected light base, 6V 5W halogen light source, mechanical stage, and field iris diaphragm. Comes complete with five magnification options: 4x / 10x / 25x / 40x /100x. 

b. Unitron ZSB Zoom Stereo Binocular microscope with a parfocal twin-zooming objective system; 0.7x through 4.5x magnification that provides a large flat field of view with high resolution. The zoom ratio of 6.5:1 gave a total magnification capability of 3.5x to 180x.

c. Eppendorf 5430 Desktop Micro-Centrifuge.

d. Savant SVC-100H Speed-Vac Concentrator.

e. Organomation Associates 113 Automatic Analytical Evaporation System.

f. Precision Scientific Reciprocal Variable-Temperature Shaking Bath.

g. Precision Scientific Thelco Oven (Model 15).

h. Lab Line Imperial II Incubator (Model 200).

Price Structure

For pricing details please contact Dr. Steven Foster, (405) 325-4749 or  

How to Submit a Sample?

(On Campus) The preferred method is to visit the MS Facility with your sample and log on to the computer Sample Submission Program. The first computer on the right inside SLSRC 1300 is for Routine Sample Submission. If you are a new user, you will have to get the staff to put your name and information into the Access Program list of users. Once this is done you will have access to the ACCESS program. The main screen has directions for one to follow. Place your printed sheet in the appropriate box and your sample in the “IN” box or the top “egg row” of the refrigerator.

(Off Campus) If you are off campus and plan to mail your samples please call and talk to Dr. Steven Foster (405-325-4749) for details. For sample analysis there is a PDF and/or Word Sample Submission document available for you to download. Fill this form out for each sample that you plan to submit. We will take care of the “log” number for you; this is used for file tracking and billing. Enclose this with your submitted sample(s). For maximum safety, please follow University’s or Company’s guidelines for mailing chemical samples.

*If you have non-routine samples you should call Dr. Foster (405-325-4749) or come by the MS Facility (SLSRC 1300) for a free consultation.*

How are the Results Received?

(On-Campus) If you are here or plan to be here a hard copy of your data is printed and placed in the appropriate slot next to the Sample Submission Computer. Leftovers of your submitted sample will be available in the “OUT” box or in the refrigerator if it is a temperature sensitive sample.

(Off-Campus) Your data will be sent electronically. It will not be interactive as proprietary software only allows data to be copied to Word or saved as a PDF. We will try to send appropriate spectra. If you have a specific spectra range or m/z that you want to see, please let us know.

Anyone can get electronic versions of their data if requested. This is necessary for presentations and publications. We will do our best to tailor your data to the appropriate venue and format.

*If you have any questions or need assistance please do not hesitate to ask, we are here to assist you with your research.*

How Are You Billed?

Several days before the end of the month, that particular months samples will be tallied and individual bills will be sent to you after the end of that month. If you do not have an account on file this must be done before any sample analysis can be done. If you are from the Oklahoma University we need to know a billable account number and your department accountant contact information. For all others we need this same information plus an address to send a hard copy of the bill.

How, Where & When to Find Us

We are typically open M-F, 8am-5pm, or can be reached by phone or email.

We are housed in the Stephenson Life Sciences Research Center which is located on the University of Oklahoma Research Campus in Norman, OK. The MSPM Core Facility is on the first floor in the NW corner, room 1300.

Contact Information:
OU Mass Spectrometry, Proteomics & Metabolomics Core Facility
Department of Chemistry & Biochemistry
Stephenson Life Sciences Research Center
101 Stephenson Parkway Norman, OK 73019

OU MSPM Facility: 
Room 1300

Photo of Steven Foster, Ph.D., Core Facility Director

Steven Foster, Ph.D., Core Facility Director
Director’s Office: Room 1301
Phone: (405) 325-4749


Photo of Nagib Ahsan, Ph.D., Proteomics Director

Nagib Ahsan, Ph.D., Proteomics Director
Research Assistant Professor
 Room 1701
Phone: (405) 325-2852


Photo of Vincent Bonifay, Ph.D., Research Scientist

Vincent Bonifay, Ph.D., Research Scientist
Office: Room 1352