Jordan Patik
Assistant Professor, Health and Exercise Science Integrative Cardiovascular Physiology Laboratory, 1401 Asp Ave, Rm 118 jordan dot patik at ou dot edu Ph.D., Kinesiology – University of Texas at Arlington, 2018RESEARCH:
My research interests center on how physical activity, diet, body composition, and other lifestyle factors impact the arterial system and influence cardiovascular health. In healthy young people, the compliance of the large central arteries functions to buffer blood pressure pulsatility and optimize cardiac performance. Healthy endothelial cells in the distal arteries and arterioles signal the vascular smooth muscle cells to dilate or constrict as needed to modulate blood pressure and tissue oxygen delivery. Modifiable (e.g., smoking) and non-modifiable (e.g., aging) risk factors lead to increases in arterial stiffness and reductions in endothelial function that, in turn, further contribute to the development of cardiovascular, metabolic, renal, and neurological diseases. Therefore, interventions targeted at preventing, delaying, or reversing vascular dysfunction may help to reduce the burden of non-communicable disease. My research aims to facilitate the development of such interventions by characterizing the causes and downstream consequences of vascular dysfunction and refining the methods for its early detection. In my laboratory, we employ non-invasive techniques like ultrasound imaging and applanation tonometry to study human macrovascular endothelial function, arterial stiffness, and ventricular-vascular interactions. We also use minimally invasive cutaneous microdialysis coupled with laser Doppler flowmetry to elucidate the mechanisms responsible for microvascular dysfunction.
Selected Publications:
Stock, J. M., Shenouda, N., Chouramanis, N. V., Patik, J. C., Martens, C. R., Farquhar, W. B., Chirinos, J. A., and Edwards, D. G. (2023) The effect of acute handgrip and aerobic exercise on wasted pressure effort and arterial wave reflections in healthy aging.. American Journal of Physiology-Heart and Circulatory Physiology 325: H617-H628.
Patik, J. C., Stock, J. M, Shenouda, N., Chouramanis, N. V., Mehrer, J. D., Chirinos, J. A., and Edwards, D.G. (2021) Pulsatile load and wasted pressure effort are reduced following an acute bout of aerobic exercise. Journal of Applied Physiology 131: 184-191.
Patik, J. C., Curtis, B. M., Nasirian, A., Vranish, J. R., Fadel, P. J., and Brothers, R. M. (2018) Sex differences in the mechanisms mediating blunted cutaneous microvascular function in young black men and women. American Journal of Physiology-Heart and Circulatory Physiology 315: H1063-H1071.
Patik, J. C., Tucker, W. J., Curtis, B. M., Nelson, M. D., Nasirian, A., Park, S., and Brothers, R. M. (2018) Fast-food meal reduces peripheral artery endothelial function but not cerebral vascular hypercapnic reactivity in healthy young men. Physiological Reports 6: e13867.
Rosenberry, R., Munson, M., Chung, S., Samuel, T. J., Patik, J. C., Tucker, W. J., Haykowsky, M. J., and Nelson, M. D. (2018) Age-related microvascular dysfunction: novel insight from near-infrared spectroscopy. Physiological Reports 6: e13867.
Vranish, J. R., Young, B. E., Kaur, J., Patik, J. C., Padilla, J., and Fadel, P. J. (2017) Influence of sex on microvascular and macrovascular responses to prolonged sitting. American Journal of Physiology-Heart and Circulatory Physiology 312: H800-H805.
Patik, J. C., Christmas, K. M., Hurr, C., and Brothers, R. M. (2015) Impaired endothelium independent vasodilation in the cutaneous microvasculature of young obese adults. Microvascular Research 104: 63-68.