Vivek Bajpai

Assistant Professor

Email: vkbajpai@ou.edu
Phone: (405) 325-4236
Office: Sarkeys Energy Center, T-225
Google Scholar
Website

Education
Ph.D. Chemical Engineering (2015)
University at Buffalo-SUNY
M.S. Biological Sciences & Bioengineering (2008)
Indian Institute of Technology Kanpur (India)
M.B.B.S. Medicine & Surgery (2005)
Maharani Laxmi Bai Medical College (India)

Research Focus

Genome Engineering
High-throughput CRISPR Screening
Functional Genomics
Stem Cells and Tissue Engineering
Pluripotent Stem Cells based Disease Modeling
Biomarkers and Drug Discovery
Systems Biology
Synthetic Biology

Experience and Awards

Postdoctoral Fellowship, Chemical & Systems Biology (2022) Stanford University
Review Editor, Biochemical Engineering, Frontiers in Chemical Engineering (2022-)
Review panelist for NIH Clinical and Translational Science Award pilot studies 2015
Oklahoma Center for Adult Stem Cell Research Grant Award, 2023
Mansour Award, Chemical and Systems Biology, Stanford University, 2018
Horizon Award, U.S. Department of Defense, 2017
WNYSTEM Stem Cells and Regenerative Medicine conference Award, 2015
Graduate Research Symposium Award, Chemical & Biological Engineering, University at Buffalo-SUNY, 2013
University Gold Medal, M.B.B.S., 2005

About

We are a discovery driven laboratory working at the intersection of Engineering, Biology and Medicine. Our research combines diverse approaches (e.g., human stem cells, tissue and animal models, CRISPR-Cas9 based genome editing, systems biology, cell & molecular biology, Imaging, microfluidics and tissue engineering) with engineering principles to investigate fundamental cellular processes with the aim to engineer novel interventions for human health and environmental applications. For more information, please visit our lab website (https://bajpai-lab.com/).

Selected Publications

Bajpai VK, Swigut T, Mohammed J, Naqvi S, Arreola M, Tycko J, Kim TC, Arora N, Pritchard JK, Bassik MC, Wysocka J. A genome-wide genetic screen uncovers novel determinants of human pigmentation. bioRxiv https://doi.org/10.1101/2021.09.29.462413. 2021 October. doi: 10.1101/2021.09.29.462413.
Roodgar M, Suchy FP, Nguyen LH, Bajpai VK, Sinha R, Vilches-Moure JG, Van Bortle K, Bhadury J, Metwally A, Jiang L, Jian R, Chiang R, Oikonomopoulos A, Wu JC, Weissman IL, Mankowski JL, Holmes S, Loh KM, Nakauchi H, VandeVoort CA, Snyder MP. Chimpanzee and pig-tailed macaque iPSCs: Improved culture and generation of primate cross-species embryos. Cell Rep. 2022 Aug 30;40(9):111264. doi: 10.1016/j.celrep.2022.111264. PubMed PMID: 36044843; NIHMSID:NIHMS1856423.
Gokhman D, Agoglia RM, Kinnebrew M, Gordon W, Sun D, Bajpai VK, Naqvi S, Chen C, Chan A, Chen C, Petrov DA, Ahituv N, Zhang H, Mishina Y, Wysocka J, Rohatgi R, Fraser HB. Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution. Nat Genet. 2021 Apr;53(4):467-476. doi: 10.1038/s41588-021-00804-3. Epub 2021 Mar 17. PubMed PMID: 33731941; PubMed Central PMCID: PMC8038968.
Wong BS*, Shah SR*, Yankaskas CL*, Bajpai VK, Wu PH, Chin D, Ifemembi B, ReFaey K, Schiapparelli P, Zheng X, Martin SS, Fan CM, Quiñones-Hinojosa A, Konstantopoulos K. A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma. Nat Biomed Eng. 2021 Jan;5(1):26-40. doi: 10.1038/s41551-020-00621-9. Epub 2020 Sep 28. PubMed PMID: 32989283; PubMed Central PMCID: PMC7855796. * Equal contribution.
Moghadasi Boroujeni S, Koontz A, Tseropoulos G, Kerosuo L, Mehrotra P, Bajpai VK, Selvam SR, Lei P, Bronner ME, Andreadis ST. Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo. Sci Rep. 2019 Jul 5;9(1):9750. doi: 10.1038/s41598-019-46140-9. PubMed PMID: 31278326; PubMed Central PMCID: PMC6611768.
Yankaskas CL, Thompson KN, Paul CD, Vitolo MI, Mistriotis P, Mahendra A, Bajpai VK, Shea DJ, Manto KM, Chai AC, Varadarajan N, Kontrogianni-Konstantopoulos A, Martin SS, Konstantopoulos K. A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens. Nat Biomed Eng. 2019 Jun;3(6):452-465. doi: 10.1038/s41551-019-0400-9. Epub 2019 May 6. PubMed PMID: 31061459; PubMed Central PMCID: PMC6563615.
Tseropoulos G, Moghadasi Boroujeni S, Bajpai VK, Lei P, Andreadis ST. Derivation of neural crest stem cells from human epidermal keratinocytes requires FGF-2, IGF-1, and inhibition of TGF-β1. Bioeng Transl Med. 2018 Sep;3(3):256-264. doi: 10.1002/btm2.10109. eCollection 2018 Sep. PubMed PMID: 30377664; PubMed Central PMCID: PMC6195909.
Verma D, Bajpai VK, Ye N, Maneshi MM, Jetta D, Andreadis ST, Sachs F, Hua SZ. Flow induced adherens junction remodeling driven by cytoskeletal forces. Exp Cell Res. 2017 Oct 15;359(2):327-336. doi: 10.1016/j.yexcr.2017.08.009. Epub 2017 Aug 10. PubMed PMID: 28803065.
Bajpai VK, Kerosuo L, Tseropoulos G, Cummings KA, Wang X, Lei P, Liu B, Liu S, Popescu GK, Bronner ME, Andreadis ST. Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates. Stem Cells. 2017 May;35(5):1402-1415. doi: 10.1002/stem.2583. Epub 2017 Mar 5. PubMed PMID: 28142205; PubMed Central PMCID: PMC5543412.
Mistriotis P, Bajpai VK, Wang X, Rong N, Shahini A, Asmani M, Liang MS, Wang J, Lei P, Liu S, Zhao R, Andreadis ST. NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression. Stem Cells. 2017 Jan;35(1):207-221. doi: 10.1002/stem.2452. Epub 2016 Jul 11. PubMed PMID: 27350449.
Coulombe KL*, Bajpai VK*, Andreadis ST, Murry CE. Heart regeneration with engineered myocardial tissue. Annu Rev Biomed Eng. 2014 Jul 11;16:1-28. doi: 10.1146/annurev-bioeng-071812-152344. Epub 2014 Apr 24. Review. PubMed PMID: 24819474; PubMed Central PMCID: PMC4213953. * Equal contribution.
Bajpai VK, Mistriotis P, Loh YH, Daley GQ, Andreadis ST. Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates. Cardiovasc Res. 2012 Dec 1;96(3):391-400. doi: 10.1093/cvr/cvs253. Epub 2012 Aug 31. PubMed PMID: 22941255; PubMed Central PMCID: PMC3584971.
Bajpai VK, Andreadis ST. Stem cell sources for vascular tissue engineering and regeneration. Tissue Eng Part B Rev. 2012 Oct;18(5):405-25. doi: 10.1089/ten.TEB.2011.0264. Epub 2012 Jul 3. Review. PubMed PMID: 22571595; PubMed Central PMCID: PMC3458622.
Bajpai VK, Mistriotis P, Andreadis ST. Clonal multipotency and effect of long-term in vitro expansion on differentiation potential of human hair follicle derived mesenchymal stem cells. Stem Cell Res. 2012 Jan;8(1):74-84. doi: 10.1016/j.scr.2011.07.003. Epub 2011 Aug 9. PubMed PMID: 22099022; PubMed Central PMCID: PMC3222855.
Mishra BK, Bajpai VK, Ramanathan V, Gadre SR, Sathyamurthy N. Cation–π interaction: to stack or to spread. Molecular Physics 106 (12-13),. 2008 June; 106(12-13):1557-1566.