Matthias U. Nollert

Associate Professor

Email: nollert@ou.edu
Office: Sarkeys Energy Center, Room T-227

Education
Ph.D. Chemical Engineering (1987)
Cornell University
B.S. Chemical Engineering (1981)
University of Virginia

Research Focus

Cardiovascular and orthopedic tissue engineering
Computational fluid mechanics of cardiovascular systems
Regenerative medicine with stem cells

Experience and Awards

Postdoctoral Fellow, Rice University (1987-91)

About

Our research in the area of biomedical engineering seeks to understand the role of fluid mechanics in modulating the biology of blood cells and the cells of the blood vessel wall. There is good evidence that changes in blood flow characteristics may lead to the development of vascular disease. Only by studying vascular cells in a flowing system that closely mimics the environment found in the blood vessels can we understand how these cells behave in the body and why vascular disease occurs.

We are currently examining alterations in protein production in blood vessel wall cells that are exposed to fluid flow. We are also investigating how the response of cells to certain hormones may change if the cells are exposed to flow. In collaboration with investigators at the University of Oklahoma Health Sciences center, we are looking at the influence of fluid mechanics on the interaction between white blood cells and the blood vessel wall. These studies will determine the molecular mechanism of this interaction and may indicate new approaches for the development of drugs to prevent an inappropriate immune response.

Selected Publications

“Development of a Human Tissue-Engineered Blood Vessel from Adipose-Derived Stem Cells”, Jaclyn A. Brennan, Julien H. Arrizabalaga, and Matthias U. Nollert, Circulation Research. 111:A360, 2012.
“Single-walled carbon nanotubes do not pierce aqueous phospholipid bilayers at low salt concentration”, (2013), Shi L, Shi D, Nollert MU, Resasco DE, Striolo A., J Phys Chem B, Jun 6;117(22):6749-58.
“Development of a Small Diameter Vascular Construct using the Human Amniotic Membrane”, Jaclyn A. Brennan, Julien H. Arrizabalaga, and Matthias U. Nollert, Cardiovascular Engineering and Technology, Volume 5, Issue 1 (2014), Page 96-109.
Hardré, P. L., Ling, C., Shehab, R.L., Nanny, M., Nollert, M., Refai, H., Ramseyer, C., Herron, J. & Wollega, E.D. (2013). Teachers in an Interdisciplinary Learning Community: Engaging, Integrating and Strengthening K-12 Education. Journal of Teacher Education, 64 (5), 410-426. DOI: 10.1177/0022487113496640.
Hardré, P. L., Shehab, R.L., Ling, C., Nanny, M., Herron, J., Nollert, M., Refai, H., Ramseyer, C., & Wollega, E.D. (2014). “Designing and Evaluating a K-12 STEM Teacher Learning Opportunity in the Research University”, Evaluation and Program Planning, Volume 43, April 2014, Pages 73–82.
“Situating teachers’ developmental engineering experiences in an inquiry-based, laboratory learning environment" (2017). Hardré, P.L., C. Ling, R.L. Shehab, M.A. Nanny, M.U. Nollert, H. Refai, C. Ramseyer, J. Herron, E.D. Wollega and S.M. Huang. Teacher Development, v21 n2 p243-268, 2017.
“Fabrication of an Economical Arduino-Based Uniaxial Tensile Tester”, Nollert, M., Arrizabalaga, J. H., Simmons, A. D. (2017).. Journal of Chemical Education, 94(4), 530-33.
“Properties of porcine adipose-derived stem cells and their applications in preclinical models”. Nollert, M., Arrizabalaga, J. H. (2017). Adipocyte, 6(3), 217-223.
“The Human Amniotic Membrane: A Versatile Scaffold for Tissue Engineering”, J. Arrizabalaga and M.U. Nollert, (2018), ACS Biomater. Sci. Eng., 4 (7), pp 2226–2236.
“Oscillatory shear potentiates latent TGF-β1 activation more than steady shear using a novel force generator”, Karim Kouzbari, Mohammad R. Hossan, Julien H. Arrizabalaga, Rohan Varshnay, Aaron D. Simmons, Sandra Gostynska, Matthias U. Nollert, and Jasimuddin Ahamed, accepted by Scientific Reports January 2019.