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Samuel Roberts Noble Microscopy Laboratory

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Samuel Roberts Noble Microscopy Laboratory (SRNML)

photo by Travis Capterton

Welcome to SRNML

The Samuel Roberts Noble Microscopy Laboratory, the core microscopy facility of the University of Oklahoma-Norman, offers access to instrumentation, training, and service.

Our mission is to provide effective and efficient access to core imaging and analytical characterization technologies. We welcome all OU-Norman, OUHSC, and OMRF student, faculty, and staff researchers at our centralized location the OU-Norman main campus. Clients from other universities, foundations and industry are welcome to use this equipment as well, and such work may be done on an invoice or contract basis.

In addition to instrument access, SRNML personnel offer advice, hands-on training, education, and research collaboration. We have a range of sample preparation equipment available; our staff work with users and provide training. The SRNML aims to promote, enable, and encourage cutting-edge education and research using the core’s instrumentation. Please see our Lab Usage page to get started, and don’t hesitate to contact us.

Acknowledgement of facility use

In addition to acknowledgement or co-authorship resulting from technical support and collaboration with SRNML personnel, published data resulting from facility use should include an acknowledgement such as, "Microscopy data collection was performed at the Samuel Roberts Noble Microscopy Laboratory, an OU core facility supported by the Vice President for Research and Partnerships".

Submit your published manuscripts with SRNML acknowledgement or co-authorship to to receive $100 credit towards future facility use.

ThermoFisher Tundra cryo-TEM to be installed early 2024

Image from ThermoFisher Scientific.

Oklahoma's first dedicated cryo-TEM will be installed at OU-Norman's Stephenson Life Sciences Research Center early in 2024. The world's first commercial 100 kV field-emission TEM, it is specially designed to facilitate single particle analysis of biological molecules. The Tundra has a special loading station to maintain samples prepared by plunge-freezing locked in a film of vitreous ice to preserve the molecules' configurations in solution. The instrument also features automation software that will allow rapid formation of a sample 'atlas', where regions of interest can be selected for further detailed automated imaging.

OU's efforts will be managed jointly between the SRNML and OU's Oklahoma COBRE in Structural Biology, including the Biomolecular Structure Core. OU's Prof. Rakhi Rajan from Chemistry/ Biochemistry and the COBRE was recently featured in Science magazine, describing much needed efforts to broaden access to cryo-TEM methods.

Room renovations and site preparation for the Tundra installation are ongoing. Stay tuned for updates!