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Oklahoma COBRE in Structural Biology

3D Rendering of a protein
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Oklahoma COBRE in Structural Biology


Welcome to the website of the Oklahoma Center of Biomedical Research Excellence in Structural Biology (OCSB). This NIH-funded center supports research groups on the OU-Norman and OUHSC campuses that utilize a structural approach to study important biological macromolecules, in particular, proteins or nucleic acids that are promising targets for rational drug design.

Structural biology lies at the intersection of many different areas of biological sciences and thus has the potential of impacting numerous biomedically important fields. The OCSB was established in 2012 with an NIH COBRE Phase I award (1P20GM103640-01) and a Phase II renewal grant (2P20GM103640-06) was awarded 2017. 

In May 2022, the OCSB was awarded the NIH COBRE Phase 3 grant (P30GM145423) which will continue to provide resources for investigators at OU, OUHSC, and other institutions throughout the State of Oklahoma for structure-based biomedical studies as well as guide the OCSB-supported core facilities to a sustainable future.

View the OCSB COBRE's publications on

New Equipment

The Protein Production and Characterization Core (PPCC) facility in Norman now has a BioTek Synergy H1 Microplate Reader available. The instrument features monochromator-based optics and filter-based optics and continuously variable bandwidth monochromators for fluorescence excitation and emission wavelength selection. More information can be found here.

The Biomolecular Structure Core (BSC) facility in Norman has a new Formulatrix Rock Imager available to use for storing and viewing crystallization trials. It is equipped with UV imaging and Multi-Fluorescence Imaging (MFI) technology. More information can be found here.


COBRE Group Meetings Fall 2022

Tuesday, September 20,  2 pm  (via ZOOM)   Presenting: PPCC

Thursday, October 27,  1:30 pm  (via ZOOM)   Presenting: BSC


EAC Meeting

The next EAC meeting will take place January 12-13, 2023.

The June 2023 EAC meeting is scheduled for June 1-2, 2023