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Oklahoma COBRE in Structural Biology

3D Rendering of a protein
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Oklahoma COBRE in Structural Biology


Welcome to the website of the Oklahoma Center of Biomedical Research Excellence in Structural Biology (OCSB). This NIH-funded center supports research groups on the OU-Norman and OUHSC campuses that utilize a structural approach to study important biological macromolecules, in particular, proteins or nucleic acids that are promising targets for rational drug design.

Structural biology lies at the intersection of many different areas of biological sciences and thus has the potential of impacting numerous biomedically important fields. The OCSB was established in 2012 with an NIH COBRE Phase I award (1P20GM103640-01) and a Phase II renewal grant (2P20GM103640-06) was awarded 2017. 

In May 2022, the OCSB was awarded the NIH COBRE Phase 3 grant (P30GM145423) which will continue to provide resources for investigators at OU, OUHSC, and other institutions throughout the State of Oklahoma for structure-based biomedical studies as well as guide the OCSB-supported core facilities to a sustainable future.

View the OCSB COBRE's publications on


Congratulations to BSC Academic Director Dr. Blaine Mooers!
Dr. Mooers has won this year's SLAC Farrel W. Lytle Award for advancing synchrotron science and RNA editing research at the Department of Energy’s SLAC National Accelerator Laboratory. The annual award recognizes dedicated staff members and users of the Stanford Synchrotron Radiation Lightsource (SSRL), a DOE Office of Science user facility.
More about this recognition can be found here.

Job Opening

The Laboratory of Biomolecular Structure and Function (LBSF) in Oklahoma City, which is part of the Biomolecular Structure Core of the COBRE, has a job opening for a Staff Scientist position. The candidate should be an experienced crystallographer. More position and application information can be found here.

New Equipment

The Protein Production and Characterization Core (PPCC) facility in Norman now has a BioTek Synergy H1 Microplate Reader available. The instrument features monochromator-based optics and filter-based optics and continuously variable bandwidth monochromators for fluorescence excitation and emission wavelength selection. More information can be found here.

The Biomolecular Structure Core (BSC) facility in Norman has a new Formulatrix Rock Imager available to use for storing and viewing crystallization trials. It is equipped with UV imaging and Multi-Fluorescence Imaging (MFI) technology. More information can be found here.


COBRE Group Meetings Spring 2023 will take place via ZOOM.

Tuesday, February 14, 2023, 3 pm: Ann West and Yihan Shao presenting

Monday, March 20, 2023, 2 pm: Wei-Qun Ding and Anthony Burgett presenting

Friday, April 7, 2023, 2 pm: Vijay Somalinga and Erika Lutter presenting

EAC Meeting

The June 2023 EAC meeting is scheduled for June 1-2, 2023.