Anthony Burgett
Project Investigator
Dept. of Pharmaceutical Sciences, OUHSC
Project Title: Structure/Function of Oxysterol-Binding Protein to Guide Therapeutic Development
Email: anthony-burgett@ouhsc.edu
Website
CoPI: Christina Bourne
Sponsored Research
The Oklahoma COBRE in Structural Biology Phase 3 program provides support for research activities that will increase the number of researchers that utilize the COBRE-supported scientific core facilities. The projects that the OCSB will support typically combine structural biology approaches with other functional characterization of important biomolecules that are relevant to improving human health and will require equipment and services of the Biomolecular Structure Core and/or the Protein Production and Characterization Core.
Erika Lutter
Project Investigator
Dept. of Microbiology and Molecular Genetics, OSU
Project Title: Determining the Structure-Function Relationship of Immune-Modulatory C. trachomatis Inc Protein CT226
Email: erika.lutter@okstate.edu
Website
CoPI: Christina Bourne
Yihan Shao
Project Investigator
Dept. of Chemistry and Biochemistry, OU-Norman
Project Title: A Combined Computational and Experimental Study of CRISPR Cas9/12a Enzyme Reaction Mechanism
Email: yihan.shao@ou.edu
Website
CoPI: Rakhi Rajan
Vijay Somalinga
Project Investigator
Dept. of Biological Sciences, SWOSU
Project Title: Structural and Functional Characterization of Proteins Essential for Metabolism and Virulence in Streptococcus sanguinis
Email: vijay.somalinga@swosu.edu
Website
CoPI: Rakhi Rajan
Jialing Lin
Project Investigator
Dept. of Biochemistry & Molecular Biology, OUHSC
Project Title: Bax Pore Formation in Apoptosis: Structures of Intermediates and Mechanism of Assembly
Email: jialing-lin@ouhsc.edu
Website
Jody Summers
Project Investigator
Dept. of Cell Biology, OUHSC
Project Title: Development of Methyl Dichlorocarbonyl Compounds for Specific RALDH2 Inhibition
Email: jody-summers@ouhsc.edu
Website
Ashlee Rowe
Junior Investigator
Dept. of Biology, OU-Norman
Project Title: Scorpion Peptides That Inhibit a Transmembrane Sodium Ion Channel (Nav1.8) Regulator of Pain-Sensing Neurons: Structural Characterization of the Peptide-Nav1.8 Complex
Email: ahrowe@ou.edu
Website
Shanteri Singh
Junior Investigator
Dept. of Chemistry & Biochemistry, OU-Norman
Funding: NIH 1R01GM138800
Project Title: Development of Chemoenzymatic Platform for Facile Synthesis of Alkyl-Pyrophosphate Analogs
Email: shanteri.singh@ou.edu
Website
Xin Zhang
Pilot Project Leader
Dept. of Physiology, OUHSC
Project Title: Preparation of Tetraspanin Proteins for Structure and Function Studies
Email: xin-zhang-1@ouhsc.edu
Website
Adam Duerfeldt
Junior Investigator
Department of Medicinal Chemistry, University of Minnesota
Project Title: Structure, Function and Therapeutic Potential of Clostridium difficile Caseinolytic Protease P
Email: aduerfel@umn.edu
Website
Ralf Janknecht
Pilot Project Leader
Dept. of Cell Biology, OUHSC
Project Title: Enabling JMJD4 Inhibitor Development Through Structural Studies
Email: ralf-janknecht@ouhsc.edu
Website
Ferenc Deak
Pilot Project Leader
Dept. of Biochemistry & Molecular Biology, OUHSC
Project Title: Munc18 Mutations in Synaptic Transmission, Epileptic Seizures and Dementia
Email: fdeak@augusta.edu
Website
Wei-Qun Ding
Pilot Project Investigator
Dept. of Pathology, OUHSC
Project Titles: (1) Effects of Arginine Methylation on SRSF1-miRNA Binding and (2) The Structural Basis of SRSF1 Recognition of miRNA Sequence Motifs
Email: weiqun-ding@ouhsc.edu
Website
CoPI: Blaine Mooers
Robert Matts
Pilot Project Leader
Dept. of Biochemistry & Molecular Biology, Oklahoma State University
Project Title: Co-crystallization of TRAP1 with Inhibitors for Enhancement of Structure-based Drug Design
Email: robert.matts@okstate.edu
Website
Rakhi Rajan
Junior Investigator
Department of Chemistry & Biochemistry, OU-Norman
Project Title: Mechanistic Studies of CRISPR-Mediated Bacterial Immunity
Email: r-rajan@ou.edu
Website
Yihan Shao
Pilot Project Leader
Dept. of Chemistry & Biochemistry, OU-Norman
Project Title: Multiscale Free Energy Simulation of Enzymatic Reactions
Email: yihan.shao@ou.edu
Website
Anne Kasus-Jacobi
Junior Project Leader
Dept. of Pharmaceutical Sciences, OUHSC
Project Title: Structural Approach to Define New Functional Activities of Neutrophil Protein CAP37 in Neurodegenerative Diseases
Christina Bourne
Junior Project Leader
Dept. of Chemistry & Biochemistry, OU-Norman
Project Title: Probing the Potential of the Gyrase Inhibitor ParE for Antibacterial Applications
Email: cbourne@ou.edu
Website
Indrajeet Sharma
Pilot Project Leader
Dept. of Chemistry & Biochemistry, OU-Norman
Project Title: Structure-Based Design of Potent and Selective Inhibitors to Pro-Apoptotic Bax/Bak
Email: isharma@ou.edu
Website
Elizabeth Karr
Junior Investigator
Dept. of Microbiology & Plant Biology, OU-Norman
Project Title: Structure-Function Studies of MsvR, a Methanogen-Specific Transcriptional Regulator
Email: lizkarr@ou.edu
Website
Marie Hanigan
Project Investigator
Dept. of Cell Biology, OUHSC
Project Title: Structural Characterization of Gamma-Glutamyl Transferase Enzymes
Email: marie-hanigan@ouhsc.edu
Website
Paul Sims
Junior Investigator
Dept. of Chemistry & Biochemistry, OU-Norman
Funding: NSF-REU 1359457
Project Title: Structural and Mechanistic Studies of Essential Microbial Kinases
Email: psims@ou.edu
Website
Shanjana Awasthi
Pilot Project Investigator
Dept. of Pharmaceutical Sciences, OUHSC
Funding: NIH P20GM103648
Project Title: Structure-Function Relation of a TLR4-Interacting Surfactant Protein A-Derived Peptide
John West
Pilot Project Investigator
Nebraska Center for Virology, U. of Nebraska-Lincoln
Project Title: Allele-Specific mRNA Structures in the Regulation of MMTV Gag Translation
Email: jwest2@unl.edu
Website
Augen Pioszak
Junior Investigator
Dept. of Biochemistry & Molecular Biology, OUHSC
Funding: NIH 1R01GM104251
Project Title: RAMP-altered Class B GPCR Hormone Recognition
Email: augen-pioszak@ouhsc.edu
Website
Blaine Mooers
Junior Investigator
Dept. of Biochemistry & Molecular Biology, OUHSC
Funding: NIH 1R01 AI088011
Project Title: The Role of Non-Canonical Base Pairs in RNA Editing
Email: blaine-mooers@ouhsc.edu
Website
Jana Shen
Junior Investigator
Dept. of Pharmaceutical Sciences, U. Maryland
Funding: NIH 1R01GM098818
Project Title: Electrostatic Modulation of Protein Stability and Folding
Email: jshen@rx.umaryland.edu
Website
