The Principal Goals of the Integrative Immunology Center are to:
University of Oklahoma-Tulsa
4502 E 41st St.
Tulsa, OK 74135
Phone: 918-660-3920
Fax: 918-660-3928
Kent Teague, Ph.D. holds the George Kaiser Family Foundation Chair in Community Medicine Research. He is the Integrative Immunology Center Director and the Associate Dean for Research at the University of Oklahoma School of Community Medicine. Dr. Teague is a professor in the Department of Surgery and an adjunct professor in the Department of Psychiatry at the School of Community Medicine. He is also an adjunct associate professor at the Oklahoma State University Center for Health Sciences and an adjunct professor at the University of Oklahoma College of Pharmacy. He completed his Ph.D. in Biological Sciences at the University of Texas M.D. Anderson Cancer Center in Houston. He completed a postdoctoral fellowship in Immunology at the Howard Hughes Medical Institute at the National Jewish Research Center in Denver.
Dr. Julie H. Marino is a faculty member in the Department of Surgery at the University of Oklahoma, School of Community Medicine, Tulsa. She received her Bachelor of Arts in Biology from Covenant College before completing her PhD in Immunology at the University of Tulsa. She completed post-doctoral training in the Department of Surgery at the University of Oklahoma College of Medicine in Tulsa. She is an expert in gene expression analysis and directs the genomics research efforts at the Integrative Immunology Center.
Ashlee Rempel serves as the Integrative Immunology Center Laboratory Manager and Business Manager. Ashlee has been employed at the University of Oklahoma since 2002, beginning as a Research Assistant II in the Department of Pediatrics at the OUHSC in Oklahoma City. She joined OU - Tulsa as a Research Assistant II in 2005. She assumed the role of Research Associate and Laboratory Manager in 2009. She has a Bachelor of Science in Microbiology and a Master's in Business Administration from Oklahoma State University. She is a certified flow cytometrist and an expert in flow-based cytokine bead arrays, ELISA, MSD arrays, and other biomarker technologies.
Dr. Chibing Tan directs the Flow Cytometry Laboratory at the Integrative Immunology Center. He is an expert in multiparametric flow cytometry. He is a certified operator of the MoFlo™ XDP high-speed cell sorter. He earned his PhD in Polymer Chemistry and Physics at the Chinese Academy of Sciences, Beijing, China. He completed a postdoctoral fellowship in Biochemistry and Biophysics at the OUHSC in Oklahoma City and a second postdoctoral fellowship in Immunology at the University of Oklahoma School of Community Medicine in Tulsa.
Brenda Davis is a senior research technician with extensive experience in human tissue/blood processing, blood and saliva biomarker analyses, molecular biology and recombinant DNA technology. She serves as the Integrative Immunology Center’s clinical studies coordinator and oversees human tissue processing and cryogenic storage. She earned a Bachelor of Science in Biochemistry from The Oklahoma State University.
Brenda-davis@ouhsc.edu
Dr. Alarbi is a postdoctoral fellow in the Department of Surgery and the Integrative Immunology Center. She earned an MS in Biochemistry and a PhD in Chemistry from the University of Tulsa. She is currently doing research in the laboratories of Dr. Peter Nelson and Dr. Kent Teague.
Jonathan Savitz, Ph.D. Principal Investigator, Laureate Institute for Brain Research and Associate Professor, University of Tulsa
Projects: Neuroimaging abnormalities in major depressive disorder: Effect of inflammation (NIH - 1K01MH096077); Response to Inflammatory Challenge in Major Depressive Disorder (NIH - P20GM131212-01); Inflammatory transcripts, genes and positive valence system function in anhedonia (NIMH - 1R01MH098099)
Jerzy Bodurka, Ph.D. Chief Technology Officer, Laureate Institute for Brain Research, Associate Professor, University of Oklahoma College of Engineering
Project: Neuroscience-Based Mental Health Assessment and Prediction (NeuroMAP)- Center of Biomedical Research Excellence - (NIH - P20GM131212-01); Inflammatory transcripts, genes and positive valence system function in anhedonia (NIMH - 1R01MH098099)
Timothy Meier, Ph.D Assistant Professor of Neurosurgery, Department of Neurosurgery
Project: Inflammation and kynurenine metabolites in the acute sequelae of concussion (NIMH - 1R21NS099789)
Jennifer Hays-Grudo, Ph.D. Professor, Department of Human Development and Family Science
Projects: Child Cortisol Levels and Family Stress; Center for Integrated Research on Childhood Adversity Administrative Core - (NIH - P20GM109097)
Julie Croff, Ph.D. Assistant Professor, School of Applied Health and Education Psychology
Project: Examining Epidemiology of Folate Status Attributable to Adolescent Alcohol Use - Center for Integrated Research on Childhood Adversity (NIH - P20GM109097)
Isaac Washburn, Ph.D. Assistant Professor, Department of Human Development and Family Science
Project: Center for Integrated Research on Childhood Adversity Statistics Core (NIH - P20GM109097)
Amanda Sheffield Morris, Ph.D. Regents' Professor and George Kaiser Family Foundation Endowed Chair in Child Development, Center for Family Resilience, Department of Human Development and Family Science
Project: The Dyadic Inter-Brain Signaling (DIBS) Project: Modeling Parent-Child Inter-Brain Regulation in the Prediction of Adolescent Depressive Symptoms - Center for Integrated Research on Childhood Adversity (NIH - P20GM109097)
Karina Shreffler, Ph.D. Professor, Center for Family Resilience, Department of Human Development and Family Science
Project: Holistic Assessment of Tulsa Children's Health (HATCH) - Center for Integrated Research on Childhood Adversity (NIH - P20GM109097)
Hideo Suzuki, Ph.D Assistant Professor, Department of Educational Psychology, University of Nebraska-Lincoln; Faculty Affiliate, Center for Brain, Biology and Behavior
Project: Inflammatory transcripts, genes and positive valence system function in anhedonia (NIMH - 1R01MH098099)
David Bard, Ph.D. Director, Biomedical and Behavioral Methodology Core (BBMC) , Associate Professor, Department of Pediatrics, OU College of College of Medicine
Project: Maternal, Infant, and Early Childhood Home Visiting Program: A Collaborative Learning Innovation for Addressing Engagement/ Retention of Home Visiting (HRSA/OSDH UH4MC307450100)
Marianna Wetherill, Ph.D., M.P.H., RDN/LD, Associate Professor, Department of Health Promotions Sciences, Hudson College of Public Health and Department of Family and Community Medicine, School of Community Medicine
Project: Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma (NIDDK 1R01DK127464-01 )
Jameca Price, M.D., M.P.H., M.C.R. Assistant Professor, Associate Director of Clinical Resarch, Department of Obstetrics and Gynecology, School of Community Medicine
Projects: Recurrent urinary tract infections and heparin: a double-blind randomized trial (COMAA 20171706)
Julie Miller-Cribbs, Ph.D. Professor, Director, Anne and Henry Zarrow School of Social Work
Projects: Child Cortisol Levels and Family Stress; School of Community Medicine Summer Institute Evaluation
Diane Horm, Ph.D. George Kaiser Family Foundation Professor of Early Childhood Education ; Director, Early Childhood Education Institute
Project: Child Cortisol Levels and Family Stress
Brett McKinney, Ph.D Associate Professor, William K. Warren, Jr. Endowed Chair in Bioinformatics, Tandy School of Computer Science and Department of Mathematics
Project: Neuroscience-Based Mental Health Assessment and Prediction (NeuroMAP)- Center of Biomedical Research Excellence - (NIH - P20GM131212-01)
Matteo Avella, Ph.D Assistant Professor of Biology, Department of Biological Science, College of Engineering and Natural Sciences
Project: Molecular biology and Genetics of mouse and human reproduction
1. Blair, A, Chiaf, AL, Crockett, EK, Teague, TK, Croff, JM. Validation of Hair Ethyl Glucuronide Using Transdermal Monitoring and Self-Reported Alcohol Use in Women of Childbearing Potential. Neuropsychopharmacology Reports. (in press)
2. Meier, T. B.#, España, L. E., Nitta, M. E., Teague, T. K., Brett, B. L., Nelson, L. D., McCrea, M. A., Savitz, J. Positive association between serum quinolinic acid and functional connectivity following concussion. Brain, Behavior, and Immunity. Jan 2021, 91:531-540. PMID: 33176183
3. Zheng H, Ford BN, Bergamino M, Kuplicki R; Tulsa 1000 Investigators, Hunt PW, Bodurka J, Teague TK, Irwin MR, Yolken RH, Paulus MP, Savitz J. A Hidden Menace? Cytomegalovirus Infection is Associated with Reduced Cortical Gray Matter Volume in Major Depressive Disorder. Molecular Psychiatry. Nov 2020, PMID: 33223520
4. Savitz, J, Ford, BN, Yeh, HW, Akeman, E, Cosgrove, K, Clausen, A, Martell, C, Kirlic, N, Santiago, J, Teague, TK, Irwin, MR, Paulus, MP, Aupperle, RL. Behavioral Activation Therapy for Depression Reduces the Concentration of Circulating Quinolinic Acid. Psychological Medicine. Nov 2020, PMID: 33234171
5. Brett, B, Savitz, J, Nitta, M, España, L, Teague, TK, Nelson, L, McCrea, M, Meier, TB.. Systemic inflammation moderates the association of prior concussion with hippocampal volume and episodic memory in high school and collegiate athletes. Brain, Behavior, and Immunity, Oct 2020, 89, 380-388. PMID: 32717401.
6. Meier, TB, Nitta, ME, Teague, TK, Nelson, LD, McCrea, MC, Savitz, J. Prospective study of the effects of sport-related concussion on serum kynurenine pathway metabolites. Brain, Behavior, and Immunity, Jul 2020, 87, 715-724. PMID: 32147388
7. Ford BN, Teague TK, Bayouth M, Yolken RH, Bodurka J, Irwin MR, Paulus MP, Savitz J. Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection. Brain, Behavior, and Immunity, Jul 2020, 87:795-803. PMID: 32209361
8. Meier, TB, Huber, DL, Bohorquez-Montoya, L, Morgan, NE, Savitz, J, Teague, TK, Bazarian, JJ, Hayes, RL, Nelson, LD, McCrea, MA. A prospective study of acute blood-based biomarkers for sport-related concussion. Annals of Neurology, Jun 2020, 87(6), 907-920. PMID: 32215965.
9. Burrows, K, Stewart, JL, Antonacci, C, Kuplicki, R, Thompson, K, Taylor, A, Teague, TK, Paulus, MP. Association of poorer dietary quality and higher dietary inflammation with greater symptom severity in depressed individuals with appetite loss. Journal of Affective Disorders, Feb 2020, 263, 99-106. PMID: 31818803.
10. Croff, J, Chibing, T, Chiaf, AL, Hartwell, ML, Crockett, EK, Teague, TK. Erythrocyte and Serum Folate Collection Techniques: A Multi-Method Study of Folate Status. Vitamins & Minerals, 2020, 9, 188.
11. Cosgrove, KT, Burrows, K, Avery, JA, Kerr, KL, DeVille, DC, Aupperle, RL, Teague, TK, Drevets, WC, Simmons, WK. Appetite change profiles in depression exhibit differential relationships between systemic inflammation and activity in reward and interoceptive neurocircuitry. Brain, Behavior, and Immunity. 2020 Jan. 83, 163-171. PMID: 31604141
12. Croff, JM, Chiaf, AL, Hartwell, ML, Crockett, EK, Tan, C, Teague, TK. Electronic Nicotine Delivery Systems and Serum Folate: A Case Study. Tobacco Use Insights. Nov 2019. 12, 1-4. PMID: 31798305
13. Nitta, M., Savitz, J., Nelson, L., Teague, T. K., Hoelzle, J., McCrea, M., Meier, T. Acute elevation of serum inflammatory markers predicts symptom recovery after concussion. Neurology. 2019 Jul 30. 93 (5), e497-e507 PMID: 31270219.
14. Ford BN, Yolken RH, Aupperle RL, Teague TK, Irwin MR, Paulus MP, Savitz J. Association of Early-Life Stress With Cytomegalovirus Infection in Adults With Major Depressive Disorder. JAMA Psychiatry. 2019 Mar 6. PMID: 30840037
15. Ford, BN, Yolken, RH, Dickerson, FB, Teague, TK, Irwin, MR, Paulus, MP, Savitz, J. Reduced Immunity to Measles in Adults with Major Depressive Disorder. Psychological Medicine. Jan 2019. 49 (2), 243-249. PMID: 29552990.
16. Le, TT, Savitz, J, Suzuki, H, Misaki, M, Teague, TK, White, B, Marino, JH, Wiley, G, Gaffney, P, Drevets, W, McKinney, B, Bodurka. Identification and replication of RNA-Seq gene network modules associated with depression severity. Translational Psychiatry. Sep 5, 2018 8(1), 180. PMID: 30185774
17. Simmons, K, Burrows, K, Avery, J, Kerr, K, Taylor, A, Bodurka, J, Potter, W, Teague, TK, Drevets, W. Appetite Changes Reveal Depression Subgroups with Distinct Endocrine, Metabolic, and Immune States. Molecular Psychiatry. 2018 Jun 13. PMID: 29899546
18. Savitz J, Teague TK, Misaki M, Macaluso M, Wurfel B., Meyer M., Drevets D, Yates W, Gleason OC, Drevets W, Preskorn S. Treatment of Bipolar Depression with Minocycline and/or Aspirin: An adaptive, 2 X 2 double-blind, randomized, placebo-controlled, phase IIA clinical trial. Transl Psychiatry. 2018 Jan 24;8(1):27. PMID: 29362444
19. Meier TB, Drevets WC, Teague TK, Wurfel BE, Mueller SC, Bodurka J, Dantzer R, Savitz J. Kynurenic acid is reduced in females and oral contraceptive users: Implications for depression. Brain, Behavior, and immunity. 2018 Jan 67:59-64. PMID: 28867283
20. Suzuki H, Savitz, J, Teague TK, Gandhapudi SK, Tan, C, Misaki M, McKinney BA, Irwin, MR, Drevets, WC, Bodurka, J. Altered Populations of Natural Killer Cells, Cytotoxic T Lymphocytes, and Regulatory T Cells in Major Depressive Disorder: Association with Sleep Disturbance. Brain Behav Immun. 2017 Nov 66:193-200. PMID: 28645775
21. Cho HJ, Savitz J, Dantzer R, Teague TK, Drevets WC, Irwin MR. Sleep disturbance and kynurenine metabolism in depression. J Psychosom Res. 2017 Aug;99:1-7. PMID: 28712413.
22. Wurfel BE, Drevets WC, Bliss SA, McMillin JR, Suzuki H, Ford BN, Morris HM, Teague TK, Dantzer R, Savitz JB. Serum kynurenic acid is reduced in affective psychosis. Transl Psychiatry. 2017 May 2;7(5):e1115. PMID: 28463241.
23. Meier TB, Lancaster MA, Mayer AR, Teague TK, Savitz J. Abnormalities in Functional Connectivity in Collegiate Football Athletes with and without a Concussion History: Implications and Role of Neuroactive Kynurenine Pathway Metabolites. J Neurotrauma. 2017 Feb 15;34(4):824-837. PMID: 27618518.
24. Young KD, Drevets WC, Dantzer R, Teague TK, Bodurka J, Savitz J. Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression. Brain Behav Immun. 2016 Aug;56:335-42. PMID: 27091600
25. Meier TB, Savitz J, Singh R, Teague TK, Bellgowan PS. Smaller Dentate Gyrus and CA2 and CA3 Volumes Are Associated with Kynurenine Metabolites in Collegiate Football Athletes. J Neurotrauma. 2016 Jul 15;33(14):1349-57. PMID: 26493952
26. Singh R, Savitz J, Teague TK, Polanski DW, Mayer AR, Bellgowan PS, Meier TB. Mood symptoms correlate with kynurenine pathway metabolites following sports-related concussion. J Neurol Neurosurg Psychiatry. 2016 Jun;87(6):670-5. PMID: 26269650.
27. Meier TB, Drevets WC, Wurfel BE, Ford BN, Morris HM, Victor TA, Bodurka J, Teague TK, Dantzer R, Savitz J. Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder. Brain Behav Immun. 2016 Mar;53:39-48. PMID: 26546831
28. Meier TB, Bergamino M, Bellgowan PS, Teague TK, Ling JM, Jeromin A, Mayer AR. Longitudinal assessment of white matter abnormalities following sports-related concussion. Hum Brain Mapp. 2016 Feb;37(2):833-45. PMID: 26663463.
29. Savitz J, Dantzer R, Meier TB, Wurfel BE, Victor TA, McIntosh SA, Ford BN, Morris HM, Bodurka J, Teague TK, Drevets WC. Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder. Psychoneuroendocrinology. 2015 Dec;62:54-
30. Savitz J, Drevets WC, Wurfel BE, Ford BN, Bellgowan PS, Victor TA, Bodurka J, Teague TK, Dantzer R. Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder. Brain Behav Immun. 2015 May;46:55-9. PMID: 25686798
31. Gandhapudi SK, Tan C, Marino JH, Taylor AA, Pack CC, Gaikwad J, Van De Wiele CJ, Wren JD, Teague TK. IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol. 2015 Apr 15;194(8):3820-8. PMID: 25780034
32. Savitz J, Dantzer R, Wurfel BE, Victor TA, Ford BN, Bodurka J, Bellgowan PS, Teague TK, Drevets WC. Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. Psychoneuroendocrinology. 2015 Feb;52:200-11. PMID: 25486577
33. Savitz J, Drevets WC, Smith CM, Victor TA, Wurfel BE, Bellgowan PS, Bodurka J, Teague TK, Dantzer R. Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder.Neuropsychopharmacology. 2015 Jan;40(2):463-71. PMID: 25074636
34. Duffy FD, Miller-Cribbs JE, Clancy GP, Van De Wiele CJ, Teague TK, Crow S, Kollaja EA, Fox MD. Changing the culture of a medical school by orienting students and faculty toward community medicine. Acad Med. 2014 Dec;89(12):1630-5. PMID: 25162616.
35. Singh R, Meier TB, Kuplicki R, Savitz J, Mukai I, Cavanagh L, Allen T, Teague TK, Nerio C, Polanski D, Bellgowan PS. Relationship of collegiate football experience and concussion with hippocampal volume and cognitive outcomes. JAMA. 2014 May 14;311(18):1883-8. PMID: 24825643.
36. Savitz J, Frank MB, Victor T, Bebak M, Marino JH, Bellgowan PS, McKinney BA, Bodurka J, Kent Teague T, Drevets WC. Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain Behav Immun. 2013 Jul;31:161-71. PMID: 23064081
37. Savitz J, Preskorn S, Teague TK, Drevets D, Yates W, Drevets W. Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2x2 clinical trial. BMJ Open. 2012 Feb 22;2(1):e000643. PMID: 22357572
38. Tan C, Taylor AA, Coburn MZ, Marino JH, Van De Wiele CJ, Teague TK. Ten-color flow cytometry reveals distinct patterns of expression of CD124 and CD126 by developing thymocytes. BMC Immunol. 2011 Jun 20;12:36. PMID:
39. Li X, Naylor MF, Le H, Nordquist RE, Teague TK, Howard CA, Murray C, Chen WR. Clinical effects of in situ photoimmunotherapy on late-stage melanoma patients: a preliminary study. Cancer Biol Ther. 2010 Dec 1;10(11):1081-7. PMID: 20890121
40. Teague TK, Tan C, Marino JH, Davis BK, Taylor AA, Huey RW, Van De Wiele CJ. CD28 expression redefines thymocyte development during the pre-T to DP transition. Int Immunol. 2010 May;22(5):387-97. PMID: 20203098.
41. Marino JH, Tan C, Taylor AA, Bentley C, Van De Wiele CJ, Ranne R, Paliotta M, Broughan TA, Teague TK. Differential IL-7 responses in developing human thymocytes. Hum Immunol. 2010 Apr;71(4):329-33. PMID: 20074604
42. Marino JH, Tan C, Davis B, Han ES, Hickey M, Naukam R, Taylor A, Miller KS, Van De Wiele CJ, Teague TK. Disruption of thymopoiesis in ST6Gal I-deficient mice. Glycobiology. 2008 Sep;18(9):719-26. PMID: 18535087
43. Broughan TA, Naukam R, Tan C, Van De Wiele CJ, Refai H, Teague TK. Effects of hepatic zonal oxygen levels on hepatocyte stress responses. J Surg Res. 2008 Mar;145(1):150-60. PMID: 18164035.
44. Van de Wiele CJ, Marino JH, Tan C, Kneale HA, Weber J, Morelli JN, Davis BK, Taylor AA, Teague TK. Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Cell Immunol. 2007 Nov-Dec;250(1-2):31-9. PMID: 18321477
45. Naylor MF, Chen WR, Teague TK, Perry LA, Nordquist RE. In situ photoimmunotherapy: a tumour-directed treatment for melanoma. Br J Dermatol. 2006 Dec;155(6):1287-92. PMID: 17107404.
46. Marino JH, Van De Wiele CJ, Everhart JM, Masengale R, Naukam RJ, Schniederjan MJ, Vo S, Teague TK. Attenuation of cytokine responsiveness during T cell development and differentiation. J Interferon Cytokine Res. 2006 Oct;26(10):748-59. PMID: 17032169.
47. Rao RS, Howard CA, Teague TK. Pulmonary endothelial permeability is increased by fluid from packed red blood cell units but not by fluid from clinically-available washed units. J Trauma. 2006 Apr;60(4):851-8. PMID: 16612308.
48. Van De Wiele CJ, Marino JH, Murray BW, Vo SS, Whetsell ME, Teague TK. Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J Immunol. 2004 Apr 1;172(7):4235-44. PMID: 15034036.
49. Van De Wiele CJ, Marino JH, Whetsell ME, Vo SS, Masengale RM, Teague TK. Loss of interferon-induced Stat1 phosphorylation in activated T cells. J Interferon Cytokine Res. 2004 Mar;24(3):169-78. PMID: 15035850.
50. Naylor MF, Crowson N, Kuwahara R, Teague K, Garcia C, Mackinnis C, Haque R, Odom C, Jankey C, Cornelison RL. Treatment of lentigo maligna with topical imiquimod. Br J Dermatol. 2003 Nov;149 Suppl 66:66-70. PMID: 14616356.
Certified flow cytometrists: Ashlee Rempel, B.S., M.B.A. and Chibing Tan, Ph.D.
For instrument availability or laboratory protocol information contact:
Ashlee Rempel, B.S., M.B.A.
Phone: 918-660-3924
Fax: 918-660-3928
Email: ashlee-rempel@ouhsc.edu
LSR-II “Special Order System” 4 laser flow cytometer. (Becton Dickinson) This instrument is capable of 12-color detection and is equipped with solid state blue, green, red, and violet lasers. It has a PC workstation including FACSDiva 6.0 software for analysis and data acquisition.
MoFlo XDP High speed cell sorting cytometer. (Beckman Coulter/Cytomation) This instrument is equipped with up to 8-color detection and 4-way sorting. It has a PC workstation including Summit v5.0 acquisition and analysis software.
AutoMACS cell sorter (Miltenyi Biotec) This instrument is used for magnetic bead cell enrichment and is used to quickly enrich cells from very large starting populations.
For laboratory protocol information contact:
Julie Marino, PhD
Phone: 918-660-3934
Fax: 918-660-3928
Email: julie-marino@ouhsc.edu
ViiA7 Real-Time PCR System (Life Technologies) This is a high-throughput quantitative PCR instrument capable of rapid, high volume PCR analyses. It is the ideal instrument for gene expression studies using the RNA biobanked during this study.
MESO QUICKPLEX SQ 120 (Meso Scale Discovery) is an instrument that uses technology similar to plate-bound ELISAs but is specifically designed for high-sensitivity multiplexed assays. This instrument allows for highly sensitive analysis of cytokines and other biomarkers using small sample sizes and low inter-assay variability.
SmartCycler Real-Time PCR machine (Cepheid) This instrument has 3 separate units and can analyze 48 samples independently using up to four fluorochromes simultaneously.
ImageQuant LAS4000 (GE) This hardware/software package allows for image capture and analysis of Western blots, DNA and PCR gels, culture dishes and microscope fields.
For laboratory protocol information contact:
Brenda Davis, BS
Phone: 918-660-3910
Fax: 918-660-3928
Email: brenda-davis@ouhsc.edu
1R01DK127464-01 (Wetherill) 09/17/2020 – 08/31/2025
NIH/NIDDK
Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma (NOURISH-OK): The goal of this project is to determine how food insecurity and chronic inflammation relate to insulin resistance via diet, other health behaviors, and the microbiome. The IIC laboratories will be providing biomarker assessments for this study.
P20GM131212-01 (Paulus) 09/15/2017 – 06/30/2022
NIH/NIGMS
The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) – The IIC serves as a core biomarker laboratory for the research projects and interventions for this multicenter project.
P20GM109097 sub #6025 (Teague) 07/01/2016 – 03/31/2022
NIH/NIGMS
Center for Integrative Research on Childhood Adversity (previously the Children's Health Equity Solutions Center) –The IIC serves as the biomarker core laboratories for the research projects and interventions for this multicenter project.
