Integrative Immunology Center

Dr. Teague holds the George Kaiser Family Foundation Chair in Community Medicine Research.  He is the Integrative Immunology Center Director and the Associate Dean for Research at the University of Oklahoma School of Community Medicine.  Dr. Teague is a professor in the Department of Surgery and an adjunct professor in the Department of Psychiatry at the School of Community Medicine.  He is also an adjunct associate professor at the Oklahoma State University Center for Health Sciences and an adjunct professor at the University of Oklahoma College of Pharmacy.  He completed his Ph.D. in Biological Sciences at the University of Texas M.D. Anderson Cancer Center in Houston.  He completed a postdoctoral fellowship in Immunology at the Howard Hughes Medical Institute at the National Jewish Research Center in Denver.  

Kent-teague@ouhsc.edu  

ORCID iD: 0000-0002-4680-5440

 

Dr. Marino is a faculty member in the Department of Surgery at the University of Oklahoma, School of Community Medicine, Tulsa.  She received her Bachelor of Arts in Biology from Covenant College before completing her PhD in Immunology at the University of Tulsa. She completed post-doctoral training in the Department of Surgery at the University of Oklahoma College of Medicine in Tulsa.  She is an expert in gene expression analysis and directs the genomics research efforts at the Integrative Immunology Center.

Julie-marino@ouhsc.edu  

 

Ashlee Rempel serves as the Integrative Immunology Center Laboratory Manager and Business Manager.  Ashlee has been employed at the University of Oklahoma since 2002, beginning as a Research Assistant II in the Department of Pediatrics at the OUHSC in Oklahoma City.  She joined OU - Tulsa as a Research Assistant II in 2005.  She assumed the role of Research Associate and Laboratory Manager in 2009.  She has a Bachelor of Science in Microbiology and a Master's in Business Administration from Oklahoma State University.  She is a certified flow cytometrist and an expert in flow-based cytokine bead arrays, ELISA, MSD arrays, and other biomarker technologies.

Ashlee-rempel@ouhsc.edu

 

Dr. Tan directs the Flow Cytometry Laboratory at the Integrative Immunology Center.  He is an expert in multiparametric flow cytometry.  He is a certified operator of the MoFlo™ XDP high-speed cell sorter.  He earned his PhD in Polymer Chemistry and Physics at the Chinese Academy of Sciences, Beijing, China.  He completed a postdoctoral fellowship in Biochemistry and Biophysics at the OUHSC in Oklahoma City and a second postdoctoral fellowship in Immunology at the University of Oklahoma School of Community Medicine in Tulsa.

Chibing-tan@ouhsc.edu

 

Brenda Davis is a senior research technician with extensive experience in human tissue/blood processing, blood and saliva biomarker analyses,  molecular biology and recombinant DNA technology.  She serves as the Integrative Immunology Center’s clinical studies coordinator and oversees human tissue processing and cryogenic storage. She earned a Bachelor of Science in Biochemistry from The Oklahoma State University.  

Brenda-davis@ouhsc.edu   

 

Dr. Alarbi is a postdoctoral fellow in the Department of Surgery and the Integrative Immunology Center.  She earned an MS in Biochemistry and a PhD in Chemistry from the University of Tulsa.  She is currently doing research in the laboratories of Dr. Peter Nelson and Dr. Kent Teague.  

Ahlam-Alarbi@ouhsc.edu

 

Jonathan Savitz, Ph.D. Principal Investigator, Laureate Institute for Brain Research and Associate Professor, University of Tulsa

Projects:

NIMH R01MH123652: Neural response to inflammatory challenge in major depressive disorder. The main goals of this project are aimed at 1) elucidating the neural circuitry underlying a maladaptive homeostatic response to inflammation in MDD by using a placebo-controlled transient inflammatory response and 2) identifying brain targets relevant to inflammation-induced depression.

NIGMS P20GM131212: The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP): Research Core. The goal of the NeuroMAP is to establish  a  program  to  train  junior  researchers  with  a  pragmatic  focus  to  use  neuroscience  to  improve  mental  health. The components of the Research Core are organized to examine specific units of analyses and create an integrated infrastructure: (A) Symptoms & Behavior, (B) Circuits & Physiology, (C) Cells & Molecules, (D) Intervention, (E) Biostatistics, and (F) IT & Database.

 

Timothy Meier, Ph.D Assistant Professor of Neurosurgery, Department of Neurosurgery

Project:

NIMH - 1R21NS099789: Inflammation and kynurenine metabolites in the acute sequelae of concussion

 

Jennifer Hays-Grudo, Ph.D. Professor, Department of Psychiatry and Behavioral Sciences. Center for Integrative Research on Childhood Adversity, National Center for Wellness and Recovery

Projects:

NIMH U01DA055349: 10/24 Healthy Brain and Child Development National Consortium. The main goals of this project are to prospectively examine human brain, cognitive, behavioral, social and emotional development of children and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children.

NIGMS P20GM109097: Center for Integrative Research on Childhood Adversity - Biomarker Core. The major goals of this project are to build Oklahoma State University-Tulsa’s (OSU-Tulsa) and OU-Tulsa's research environment focused on discovering the sources of health inequities among children and to translate scientific results into solutions that eliminate children’s health inequities. The Biomarker Core is aimed at providing support for biomarker analyses for the center investigators.

 

Amanda Sheffield Morris, Ph.D. Regents' Professor and George Kaiser Family Foundation Endowed Chair in Child Development, Department of Psychiatry and Behavioral Sciences, Center for Integrative Research on Childhood Adversity

Projects:

NIMH U01DA055349: 10/24 Healthy Brain and Child Development National Consortium. The main goals of this project are to prospectively examine human brain, cognitive, behavioral, social and emotional development of children and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of childre

NIGMS P20GM1090907: The Dyadic Inter-Brain Signaling (DIBS) Project: Modeling Parent-Child Inter-Brain Regulation in the Prediction of Adolescent Depressive Symptoms - Center for Integrated Research on Childhood Adversity

 

Julie Croff, PhD, Professor, Executive Director - Population and Clinical Research, National Center for Wellness and Recovery

Projects:

NIH - P20GM109097: Examining Epidemiology of Folate Status Attributable to Adolescent Alcohol Use - Center for Integrated Research on Childhood Adversity

NIMH U01DA055349: 10/24 Healthy Brain and Child Development National Consortium. The main goals of this project are to prospectively examine human brain, cognitive, behavioral, social and emotional development of children and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children.

Bart Ford, PhD. Assistant Professor, Department of  Pharmacology and Physiology

Project: 

Brain & Behavior Research Foundation: Immune Predictors of SARS-CoV-2 Vaccine Response in Major Depressive Disorder. The main goal of this project is to examine the immune predictors of the adaptive immune response to SARS-CoV-2 vaccination in a sample of individuals with mood and anxiety disorders.

 

 

Misty Hawkins, PhD,  Assistant Professor, Department of Psychology, College of Arts and Sciences

Projects:

NIH - P20GM109097: Neurotrophic Indicators of Cognition, Executive Skills, Plasticity, and Adverse Childhood Experiences Study (NICE SPACES). Major goals are to 1) Identify whether brain markers of neural health (e.g., neurotrophins) are related to adverse childhood experiences and/or neurocognitive performance, and 2) Test whether neuronal or glial neurotrophins predict or change in response to weight loss.

 

David Bard, Ph.D. Director, Biomedical and Behavioral Methodology Core (BBMC) , Associate Professor, Department of Pediatrics, OU College of College of Medicine

Project: 

HRSA/OSDH UH4MC307450100: Maternal, Infant, and Early Childhood Home Visiting Program: A Collaborative Learning Innovation for Addressing Engagement/ Retention of Home Visiting

 

Karina Shreffler, Ph.D. Professor, College of Nursing, University of Oklahoma Health Science Center

Project: 

NIGMS P20GM109097: Holistic Assessment of Tulsa Children's Health (HATCH) - Center for Integrated Research on Childhood Adversity

 

 

Marianna Wetherill, Ph.D., M.P.H., RDN/LD, Associate Professor, Department of Health Promotions Sciences, Hudson College of Public Health and Department of Family and Community Medicine, School of Community Medicine

Project: 

NIDDK R01DK127464: Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma. The major goals of this project are to identify how food insecurity contributes to insulin resistance in HIV and to evaluate a “food as medicine” intervention designed to lower insulin resistance for people living with HIV.

 

 

Brett McKinney, Ph.D Professor of Computer Science, William K. Warren, Jr. Endowed Chair in Bioinformatics, College of Engineering and Natural Sciences

Project:

NIGMS P20GM131212: Neuroscience-Based Mental Health Assessment and Prediction (NeuroMAP)- Center of Biomedical Research Excellence - Research Core. The goal of the NeuroMAP is to establish  a  program  to  train  junior  researchers  with  a  pragmatic  focus  to  use  neuroscience  to  improve  mental  health. The components of the Research Core are organized to examine specific units of analyses and create an integrated infrastructure: (A) Symptoms & Behavior, (B) Circuits & Physiology, (C) Cells & Molecules, (D) Intervention, (E) Biostatistics, and (F) IT & Database.

 

1.      Figureroa-Hall, L, Xu, B, Kuplicki, Ford, B, Burrows, K., Teague, TK, Sen, S, Yeh, H-W, Irwin, M, Savitz, J, Paulus, M (2022) Psychiatric symptoms are not associated with circulating CRP concentrations after controlling for medical, social, and demographic factors. Translational Psychiatry. 12(1), 279. PMID: 35821205.

2.      Burrows, K, Figueroa-Hall, LK, Kuplicki, R, Stewart, JL, Alarbi, AM, Ramesh, R, Savitz, JB, Teague, TK, Risbrough, VB, Paulus, MP. (2022) Neuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial. Scientific Reports, 12(1), 861. PMID: 35039595.

3.      MacGregor, T, Savitz, J, Zhang, Y, Burrows, K, Smith, R, Figueroa-Hall, L, Kuplicki, R, Khalsa, SS, Taki, Y, Teague, TK, Irwin, MR, Yeh, F-C, Paulus, MP, Zheng, H. (2021) Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression. Life, 12(1), 43. PMID: 35054436.

4.      Meier, T, Guedes, V, Smith, E, Sass, D, Mithani, S, Vorn, R, Savitz, J, Teague, TK, McCrea, M, Gill, J. (2021) Extracellular vesicle-associated cytokines in sport-related concussion. Brain, Behavior, and Immunity, 100, 83-87. PMID: 34848337.

5.      Zheng, H, Ford, BN, Kuplicki, R, Burrows, K, Hunt, PW, Bodurka, J, Teague, TK, Irwin, MR, Yolken, RH, Paulus, MP, Savitz, J. (2021) Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension. Translational Psychiatry, 11(1), 464. PMID: 34493708.

6.      Jenkins, ND, Rogers, EM, Banks, NF, Tomco, PM, Sciarrillo, CM, Emerson, SR, Taylor, A, Teague, TK. (2021) Childhood psychosocial stress is linked with impaired vascular endothelial function, lower SIRT1, and oxidative stress in young adulthood. Am J Physiol Heart Circ Physiol, 321(3), 532-541. PMID: 34328346.

7.      Kuplicki, R, Touthang, J, Al Zoubi, O, Mayeli, A, Misaki, M, Investigators, N, Aupperle, RL, Teague, TK, McKinney, BA, Paulus, MP, Bodurka, J. (2021) Common Data Elements, Scalable Data Management Infrastructure and Analytics Workflows for Large-scale Neuroimaging Studies. Frontiers in Psychiatry. 12:682495. PMID: 34220587

8.      Cosgrove, KT, Kuplicki, R, Savitz, J, Simmons, K, Khalsa, SS, Aupperle, RL, Teague, TK, Paulus, MP. (2021) Impact of ibuprofen and peroxisome proliferator-activated receptor gamma on emotion-related neural activation: A randomized, placebo-controlled trial. Brain, Behavior, and Immunity. 96:135-142. PMID: 34052365

9.      Cohen, ZP, Cosgrove, KT, Akeman, E, Coffey, S, Teague, K, Hays-Grudo, J, Paulus, MP, Aupperle, RL, Kirlic, N. (2021) The effect of a mindfulness-based stress intervention on neurobiological and symptom measures in adolescents with early life stress: a randomized feasibility study. BMC Complementary Medicine and Therapies, 21, 123. PMID: 33858395.

10.  Burrows, K, Ste, JL, Kuplicki, R, Figueroa-Hall, L, Spechler, PA, Zheng, H, Guinjoan, SM, Tulsa 1000 Investigators, Savitz, JB, Teague, TK, Paulus, MP. (2021) Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder. Brain, Behavior, and Immunity, 93, 214-225. PMID: 33508469.

11.  Blair, A, Chiaf, AL, Crockett, EK, Teague, TK, Croff, JM. (2021) Validation of Hair Ethyl Glucuronide Using Transdermal Monitoring and Self-Reported Alcohol Use in Women of Childbearing Potential. Neuropsychopharmacology Reports. PMID: 33650766.

12.  Meier, TB, España, LE, Nitta, ME, Teague, TK, Brett, BL, Nelson, LD, McCrea, MA, Savitz, J. (2021) Positive association between serum quinolinic acid and functional connectivity following concussion. Brain, Behavior, and Immunity, 91, 531-540. PMID: 33176183.

13.  Shreffler, KM, Joachims, CN, Tiemeyer, S, Simmons, WK, Teague, TK, Hays-Grudo, J. (2021) Childhood Adversity and Perceived Distress from the COVID-19 Pandemic. Adversity and Resilience Science. PMID: 33527096.

14.  Zheng, H, Bergamino, M, Ford, BN, Kuplicki, R, Yeh, F-C, Bodurka, J., Burrows, K, Tulsa 1000 Investigators, Hunt, PW, Teague, TK, Irwin, MR, Yolken, RH, Paulus, MP, Savitz, J. (2021) Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder. Neuropsychopharmacology. PMID: 33500556.

15.  Tsuchiyagaito A, Smith JL, El-Sabbagh N, Zotev V, Misaki M, Al Zoubi O, Kent Teague T, Paulus MP, Bodurka J, Savitz J. (2021) Real-time fMRI neurofeedback amygdala training may influence kynurenine pathway metabolism in major depressive disorder.  Neuroimage Clin. 29:102559. PMID: 33516062 

16.  Blair AL, Chiaf AL, Crockett EK, Teague TK, Croff JM. (2021) Validation of hair ethyl glucuronide using transdermal monitoring and self-reported alcohol use in women of childbearing potential. Neuropsychopharmacol Rep. 41(2):144-151. PMID: 33650766

17.  Meier, T. B., España, L. E., Nitta, M. E., Teague, T. K., Brett, B. L., Nelson, L. D., McCrea, M. A., Savitz, J. (2021) Positive association between serum quinolinic acid and functional connectivity following concussion. Brain, Behavior, and Immunity. 91:531-40. PMID: 33176183

18.  Zheng H, Ford BN, Bergamino M, Kuplicki R; Tulsa 1000 Investigators, Hunt PW, Bodurka J, Teague TK, Irwin MR, Yolken RH, Paulus MP, Savitz J. (2020) A Hidden Menace? Cytomegalovirus Infection is Associated with Reduced Cortical Gray Matter Volume in Major Depressive Disorder. Molecular Psychiatry. 26(8):4234-244. PMID: 33223520

19.  Savitz, J, Ford, BN, Yeh, HW, Akeman, E, Cosgrove, K, Clausen, A, Martell, C, Kirlic, N, Santiago, J, Teague, TK, Irwin, MR, Paulus, MP, Aupperle, RL. (2020) Behavioral Activation Therapy for Depression Reduces the Concentration of Circulating Quinolinic Acid. Psychological Medicine. Nov. 25, 1-10. PMID: 33234171

20.  Brett, B, Savitz, J, Nitta, M, España, L, Teague, TK, Nelson, L, McCrea, M, Meier, TB. (2020) Systemic inflammation moderates the association of prior concussion with hippocampal volume and episodic memory in high school and collegiate athletes. Brain, Behavior, and Immunity, 89, 380-88. PMID: 32717401.

21.  Meier, TB, Nitta, ME, Teague, TK, Nelson, LD, McCrea, MC, Savitz, J. Prospective study of the effects of sport-related concussion on serum kynurenine pathway metabolites. Brain, Behavior, and Immunity, Jul 2020, 87, 715-24. PMID: 32147388

22.  Ford BN, Teague TK, Bayouth M, Yolken RH, Bodurka J, Irwin MR, Paulus MP, Savitz J. (2020) Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection. Brain, Behavior, and Immunity, 87:795-803. PMID: 32209361

23.  Meier, TB, Huber, DL, Bohorquez-Montoya, L, Morgan, NE, Savitz, J, Teague, TK, Bazarian, JJ, Hayes, RL, Nelson, LD, McCrea, MA. (2020) A prospective study of acute blood-based biomarkers for sport-related concussion. Annals of Neurology, 87(6), 907-20. PMID: 32215965.

24.  Burrows, K, Stewart, JL, Antonacci, C, Kuplicki, R, Thompson, K, Taylor, A, Teague, TK, Paulus, MP. (2020) Association of poorer dietary quality and higher dietary inflammation with greater symptom severity in depressed individuals with appetite loss. Journal of Affective Disorders, 263, 99-106. PMID: 31818803.

25.  Croff, J, Chibing, T, Chiaf, AL, Hartwell, ML, Crockett, EK, Teague, TK. (2020) Erythrocyte and Serum Folate Collection Techniques: A Multi-Method Study of Folate Status. Vitamins & Minerals, 9, 188.

26.  Cosgrove, KT, Burrows, K, Avery, JA, Kerr, KL, DeVille, DC, Aupperle, RL, Teague, TK, Drevets, WC, Simmons, WK. (2020) Appetite change profiles in depression exhibit differential relationships between systemic inflammation and activity in reward and interoceptive neurocircuitry. Brain, Behavior, and Immunity. 83, 163-171. PMID: 31604141

27.  Croff, JM, Chiaf, AL, Hartwell, ML, Crockett, EK, Tan, C, Teague, TK. (2019) Electronic Nicotine Delivery Systems and Serum Folate: A Case Study. Tobacco Use Insights. 12, 1-4. PMID: 31798305

28.  Nitta, M., Savitz, J., Nelson, L., Teague, T. K., Hoelzle, J., McCrea, M., Meier, T. (2019) Acute elevation of serum inflammatory markers predicts symptom recovery after concussion. Neurology. 93 (5), e497-e507 PMID: 31270219. 

29.  Ford BN, Yolken RH, Aupperle RL, Teague TK, Irwin MR, Paulus MP, Savitz J. (2019) Association of Early-Life Stress With Cytomegalovirus Infection in Adults With Major Depressive Disorder. JAMA Psychiatry. 76(5):545-47. PMID: 30840037

30.  Ford, BN, Yolken, RH, Dickerson, FB, Teague, TK, Irwin, MR, Paulus, MP, Savitz, J. (2019) Reduced Immunity to Measles in Adults with Major Depressive Disorder. Psychological Medicine. 49 (2), 243-49. PMID: 29552990. 

31.  Le, TT, Savitz, J, Suzuki, H, Misaki, M, Teague, TK, White, B, Marino, JH, Wiley, G, Gaffney, P, Drevets, W, McKinney, B, Bodurka. (2018) Identification and replication of RNA-Seq gene network modules associated with depression severity. Translational Psychiatry. 8(1), 180. PMID: 30185774

32.  Simmons, K, Burrows, K, Avery, J, Kerr, K, Taylor, A, Bodurka, J, Potter, W, Teague, TK, Drevets, W. (2018)  Appetite Changes Reveal Depression Subgroups with Distinct Endocrine, Metabolic, and Immune States. Molecular Psychiatry. 25(7):1457-1468 PMID: 29899546

33.  Savitz J, Teague TK, Misaki M, Macaluso M, Wurfel B., Meyer M., Drevets D, Yates W, Gleason OC, Drevets W, Preskorn S. (2018) Treatment of Bipolar Depression with Minocycline and/or Aspirin: An adaptive, 2 X 2 double-blind, randomized, placebo-controlled, phase IIA clinical trial. Transl Psychiatry. 8(1):27. PMID: 29362444

34.  Meier TB, Drevets WC, Teague TK, Wurfel BE, Mueller SC, Bodurka J, Dantzer R, Savitz J. (2018) Kynurenic acid is reduced in females and oral contraceptive users: Implications for depression. Brain Behav Immun. 67:59-64. PMID: 28867283

35.  Suzuki H, Savitz, J, Teague TK, Gandhapudi SK, Tan, C, Misaki M, McKinney BA, Irwin, MR, Drevets, WC, Bodurka, J. (2017) Altered Populations of Natural Killer Cells, Cytotoxic T Lymphocytes, and Regulatory T Cells in Major Depressive Disorder: Association with Sleep Disturbance. Brain Behav Immun. 66:193-200. PMID: 28645775 

36.  Cho HJ, Savitz J, Dantzer R, Teague TK, Drevets WC, Irwin MR. (2017) Sleep disturbance and kynurenine metabolism in depression. J Psychosom Res. 99:1-7. PMID: 28712413.

37.  Wurfel BE, Drevets WC, Bliss SA, McMillin JR, Suzuki H, Ford BN, Morris HM, Teague TK, Dantzer R, Savitz JB. (2017) Serum kynurenic acid is reduced in affective psychosis. Transl Psychiatry. 7(5):e1115. PMID: 28463241.

38.  Meier TB, Lancaster MA, Mayer AR, Teague TK, Savitz J. (2017) Abnormalities in Functional Connectivity in Collegiate Football Athletes with and without a Concussion History: Implications and Role of Neuroactive Kynurenine Pathway Metabolites. J Neurotrauma. 34(4):824-837. PMID: 27618518.

39.  Young KD, Drevets WC, Dantzer R, Teague TK, Bodurka J, Savitz J. (2016) Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression. Brain Behav Immun. 56:335-42. PMID: 27091600

40.  Meier TB, Savitz J, Singh R, Teague TK, Bellgowan PS. (2016) Smaller Dentate Gyrus and CA2 and CA3 Volumes Are Associated with Kynurenine Metabolites in Collegiate Football Athletes. J Neurotrauma. 33(14):1349-57. PMID: 26493952

41.  Singh R, Savitz J, Teague TK, Polanski DW, Mayer AR, Bellgowan PS, Meier TB. (2016) Mood symptoms correlate with kynurenine pathway metabolites following sports-related concussion. J Neurol Neurosurg Psychiatry. 87(6):670-5. PMID: 26269650.

42.  Meier TB, Drevets WC, Wurfel BE, Ford BN, Morris HM, Victor TA, Bodurka J, Teague TK, Dantzer R, Savitz J. (2016) Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder. Brain Behav Immun. 53:39-48. PMID: 26546831

43.  Meier TB, Bergamino M, Bellgowan PS, Teague TK, Ling JM, Jeromin A, Mayer AR. (2016) Longitudinal assessment of white matter abnormalities following sports-related concussion. Hum Brain Mapp. 37(2):833-45. PMID: 26663463.

44.  Savitz J, Dantzer R, Meier TB, Wurfel BE, Victor TA, McIntosh SA, Ford BN, Morris HM, Bodurka J, Teague TK, Drevets WC. (2015) Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder. Psychoneuroendocrinology. 62:54-8

45.  Savitz J, Drevets WC, Wurfel BE, Ford BN, Bellgowan PS, Victor TA, Bodurka J, Teague TK, Dantzer R. (2015) Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder. Brain Behav Immun.46:55-9. PMID: 25686798

46.  Gandhapudi SK, Tan C, Marino JH, Taylor AA, Pack CC, Gaikwad J, Van De Wiele CJ, Wren JD, Teague TK. (2015) IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol. 194(8):3820-8. PMID: 25780034

47.  Savitz J, Dantzer R, Wurfel BE, Victor TA, Ford BN, Bodurka J, Bellgowan PS, Teague TK, Drevets WC. (2015) Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. Psychoneuroendocrinology. 52:200-11. PMID: 25486577

48.  Savitz J, Drevets WC, Smith CM, Victor TA, Wurfel BE, Bellgowan PS, Bodurka J, Teague TK, Dantzer R. (2015) Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder. Neuropsychopharmacology. 40(2):463-71. PMID: 25074636

49.  Duffy FD, Miller-Cribbs JE, Clancy GP, Van De Wiele CJ, Teague TK, Crow S, Kollaja EA, Fox MD. (2014) Changing the culture of a medical school by orienting students and faculty toward community medicine. Acad Med. 89(12):1630-5. PMID: 25162616.

50.  Singh R, Meier TB, Kuplicki R, Savitz J, Mukai I, Cavanagh L, Allen T, Teague TK, Nerio C, Polanski D, Bellgowan PS. (2014) Relationship of collegiate football experience and concussion with hippocampal volume and cognitive outcomes. JAMA. 201311(18):1883-8. PMID: 24825643.

51.  Savitz J, Frank MB, Victor T, Bebak M, Marino JH, Bellgowan PS, McKinney BA, Bodurka J, Kent Teague T, Drevets WC. (2013) Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain Behav Immun. 31:161-71. PMID: 23064081

52.  Savitz J, Preskorn S, Teague TK, Drevets D, Yates W, Drevets W. (2012) Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2x2 clinical trial. BMJ Open. 2(1):e000643. PMID: 22357572

53.  Tan C, Taylor AA, Coburn MZ, Marino JH, Van De Wiele CJ, Teague TK. (2011) Ten-color flow cytometry reveals distinct patterns of expression of CD124 and CD126 by developing thymocytes. BMC Immunol. 12:36. PMID:

54.  Li X, Naylor MF, Le H, Nordquist RE, Teague TK, Howard CA, Murray C, Chen WR. (2010) Clinical effects of in situ photoimmunotherapy on late-stage melanoma patients: a preliminary study. Cancer Biol Ther. 10(11):1081-7.  PMID: 20890121

55.  Teague TK, Tan C, Marino JH, Davis BK, Taylor AA, Huey RW, Van De Wiele CJ. (2010) CD28 expression redefines thymocyte development during the pre-T to DP transition. Int Immunol. 22(5):387-97. PMID: 20203098.

56.  Marino JH, Tan C, Taylor AA, Bentley C, Van De Wiele CJ, Ranne R, Paliotta M, Broughan TA, Teague TK. (2010) Differential IL-7 responses in developing human thymocytes. Hum Immunol. 71(4):329-33. PMID: 20074604

57.  Marino JH, Tan C, Davis B, Han ES, Hickey M, Naukam R, Taylor A, Miller KS, Van De Wiele CJ, Teague TK. (2008) Disruption of thymopoiesis in ST6Gal I-deficient mice. Glycobiology. 18(9):719-26. PMID: 18535087

58.  Broughan TA, Naukam R, Tan C, Van De Wiele CJ, Refai H, Teague TK. (2008) Effects of hepatic zonal oxygen levels on hepatocyte stress responses. J Surg Res. 145(1):150-60. PMID: 18164035.

59.  Van de Wiele CJ, Marino JH, Tan C, Kneale HA, Weber J, Morelli JN, Davis BK, Taylor AA, Teague TK. (2007) Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Cell Immunol. 250(1-2):31-9. PMID: 18321477

60.  Naylor MF, Chen WR, Teague TK, Perry LA, Nordquist RE. (2006) In situ photoimmunotherapy: a tumour-directed treatment for melanoma. Br J Dermatol. 155(6):1287-92. PMID: 17107404.

61.  Marino JH, Van De Wiele CJ, Everhart JM, Masengale R, Naukam RJ, Schniederjan MJ, Vo S, Teague TK. (2006) Attenuation of cytokine responsiveness during T cell development and differentiation. J Interferon Cytokine Res. 26(10):748-59. PMID: 17032169.

62.  Rao RS, Howard CA, Teague TK. (2006) Pulmonary endothelial permeability is increased by fluid from packed red blood cell units but not by fluid from clinically-available washed units. J Trauma. 60(4):851-8. PMID: 16612308.

63.  Van De Wiele CJ, Marino JH, Murray BW, Vo SS, Whetsell ME, Teague TK. (2004) Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J Immunol. 172(7):4235-44. PMID: 15034036.

64.  Van De Wiele CJ, Marino JH, Whetsell ME, Vo SS, Masengale RM, Teague TK. (2004) Loss of interferon-induced Stat1 phosphorylation in activated T cells. J Interferon Cytokine Res. 24(3):169-78. PMID: 15035850.

65.  Naylor MF, Crowson N, Kuwahara R, Teague K, Garcia C, Mackinnis C, Haque R, Odom C, Jankey C, Cornelison RL. (2003) Treatment of lentigo maligna with topical imiquimod. Br J Dermatol. 149 Suppl 66:66-70. PMID: 14616356.

Certified flow cytometrists: Ashlee Rempel, B.S., M.B.A. and Chibing Tan, Ph.D.

For instrument availability or laboratory protocol information contact:
Ashlee Rempel, B.S., M.B.A.
Phone: 918-660-3924
Fax: 918-660-3928
Email: ashlee-rempel@ouhsc.edu

 

AutoMACS cell sorter (Miltenyi Biotec) This instrument is used for magnetic bead cell enrichment and is used to quickly enrich cells from very large starting populations.

For laboratory protocol information contact:
Julie Marino, PhD
Phone: 918-660-3934
Fax: 918-660-3928
Email: julie-marino@ouhsc.edu

MESO QUICKPLEX SQ 120 (Meso Scale Discovery) is an instrument  that uses technology similar to plate-bound ELISAs but is specifically designed for high-sensitivity multiplexed assays.  This instrument allows for highly sensitive analysis of cytokines and other biomarkers using small sample sizes and low inter-assay variability.

SmartCycler Real-Time PCR machine (Cepheid) This instrument has 3 separate units and can analyze 48 samples independently using up to four fluorochromes simultaneously.  

ImageQuant LAS4000 (GE) This hardware/software package allows for image capture and analysis of Western blots, DNA and PCR gels, culture dishes and microscope fields.

For laboratory protocol information contact:
Brenda Davis, BS
Phone: 918-660-3910
Fax: 918-660-3928
Email: brenda-davis@ouhsc.edu

 

P20GM109097 (Hays-Grudo) 09/06/2022– 06/30/2027

NIH/NIGMS

Center for Integrative Research on Childhood Adversity – The IIC serves as the biomarker core laboratories for the research projects and interventions for this multicenter project. The major goals of the project are to build a Tulsa research environment focused on discovering the sources of health inequities among children and to translate scientific results into solutions that eliminate children’s health inequities. 

 

R01MH123652 (Savitz)  04/01/2021 - 03/31/2026

NIH/NIMH

Neural response to inflammatory challenge in major depressive disorder: The aim of this research is to test how depressed and healthy individuals differ in their neural, immunological, and behavioral responses to an acute inflammatory challenge.  The IIC is providing immunology expertise and laboratory support to the project.

R01DK127464 (Wetherill)  09/17/2020 – 08/31/2025

NIH/NIDDK

Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma (NOURISH-OK): The goal of this project is to determine how food insecurity and chronic inflammation relate to insulin resistance via diet, other health behaviors, and the microbiome. The IIC laboratories are providing biomarker assessments for this study. 

 

BBRF Foundation Grant (Ford) 01/01/2022 - 12-31-2024

Immune Predictors of SARS-CoV-2 Vaccine Response in Major Depressive Disorder: The main goals of this project are to prospectively examine human brain, cognitive, behavioral, social and emotional development of children and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children.  The IIC is providing immunology expertise and laboratory support to the project.

 

HR21-021 (Criss) 12/01/2021 - 11/30/2024

OCAST

Link Between Chronic Adversity and Emerging Adult Mental and Physical Health: An Examination of Underlying Bio-Social Mechanisms and Protective Factors. The main goals of this project are to identify potential pathways linking social and environmental adversity, biological processes, and mental and physical health and to elucidate potential relationship processes that serve as protective factors.  The IIC is providing laboratory support to the project.

 

P20GM131212-01 (Paulus) 09/15/2017 – 06/30/2022

NIH/NIGMS

The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) – The IIC serves as a core biomarker laboratory for the research projects and interventions for this multicenter project.