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Lauren E. EthridgeAssistant Professor, Psychology and Pediatrics Dale Hall Tower 739 405-325-4497 ethri at ou dot edu https://ouhsc.edu/bbmc/babl/ Ph.D., Neuroscience, University of Georgia, 2011
The Brain and Biomarker Laboratory, under the direction of Dr. Lauren Ethridge, is a multidisciplinary, translational neuroscience laboratory focusing on applications of basic science to clinical outcomes, particularly in neurodevelopmental disorders.
The BABL group centers on the use of dense-array EEG as a translational tool for learning more about brain function in neurodevelopmental disorders. The ultimate goal of our research is to establish non-invasive biological markers for changes in brain function that not only elucidate neural and molecular pathways affected by disorders such as Autism Spectrum Disorder but also serve as aids for early identification, early predictors for response to individualized treatment protocols, and reliable indicators of treatment effects.
Research in the lab is highly collaborative, with a large network of investigators across the country. Current research includes:
1. EEG as a translational, treatment sensitive, biomarker in rare genetic disorders associated with autism, including Fragile X Syndrome and Phelan-McDermid Syndrome
2. Neural correlates of face processing in toddlers at risk for autism
3. Characteristics of EEG activity related to variation in ASD symptoms across the full spectrum, including subclinical characteristics in the typically developing population
4. Dense phenotyping of biologically based subtypes (“biotypes”) across the schizo-bipolar spectrum of psychosis
Pedapati, E., Schmitt, L., Liu, R., Ethridge, L., Smith, E., Sweeney, J., Shaffer, R., Dominick, K., Gilbert, D., Wu, S., Horn, P., Binder, D., Lamy, M., Axford, M., Miyakoshi, M., and Erickson, C. (2021) Neocortical Localization and Thalamocortical Modulation of Neuronal Hyperexcitability in Fragile X Syndrome. MedRxiv (preprint).
Berry-Kravis, E. M., Harnett, M. D., Reines, S. A., Reese, M. A., Ethridge, L. E. Outterson, A. H., Michalak, C., Furman, J., and Gurney, M. (2021) Benefit of BPN14770 for cognition, language, and daily function in adults with fragile x syndrome: A randomized, placebo-controlled, phase 2 clinical trial. Nature Medicine 27: 862-870.
Mariscal, M. G., Berry-Kravis, E., Buxbaum, J. D., Ethridge, L. E., Filip-Dhima, R., Foss-Feig, J. H., Kolevzon, A., Modi, M. E., Mosconi, M. W., Nelson, C. A., Powell, C. M. Siper, P. M., Soorya, L., Thaliath, A., Thurm, A., Zhang, B., Sahin, M. and Levin, A. R. (2021) Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid Syndrome. Molecular Autism, 12(1): 1-12.
Ethridge, L. E., Thaliath, A., Kraff, J., Nijhawan, K., and Berry-Kravis, E., (2020) Development of neural response to novel sounds in fragile x syndrome: potential biomarkers. American Journal on Intellectual and Developmental Disabilities 125 (6): 449-464.
Reese, M., Bryant, D., and Ethridge, L. E. (2020) Biomarkers for moral cognition: Current status and future prospects for neurotransmitters and neuropeptides. Neuroscience and Biobehavioral Reviews 113: 88-97.
Ethridge, L. E., De Stefano, L. A. Schmitt, L. S., Woodruff, N. E., Brown, K. L., Tran, M., Wang, J., Pedapati, E., Erickson, C. A., and Sweeney, J. A. (2019) Auditory EEG Biomarkers in Fragile X Syndrome: Clinical Relevance. Frontiers in Integrative Neuroscience 13: 60.
De Stefano, L. A., Schmitt, L. M., White, S. P., Mosconi, M. W., Sweeney, J. A., and Ethridge, L. E. (2019) Developmental effects on auditory neural oscillatory synchronization abnormalities in autism spectrum disorder. Frontiers in Integrative Neuroscience 13: 34.
Shou, G., Mosconi, M., Ethridge, L., Sweeney, J., and Ding, L. (2018) Resting-state gamma-band EEG abnormalities in autism. Proceedings of 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: 1915-1918.
Hudgens-Haney, M. E., Ethridge, L. E., Knight, J. B., McDowell, J. E., Keedy, S. K., Pearlson, G. D., Tamminga, C. A., Keshavan, M. S., Sweeney, J. A., and Clementz, B. A. (2018) Psychosis subgroups differ in intrinsic neural activity but not task-specific processing. Schizophrenia Research 195: 222-230.
Hudgens-Haney, M. E., Ethridge, L. E., Knight, J. B., McDowell, J. E., Keedy, S. K., Pearlson, G. D., Tamminga, C. A., Keshavan, M. S., Sweeney, J. A., and Clementz, B. A. (2017) Intrinsic neural activity differences among psychotic illnesses. Psychophysiology 54(8): 1223–1238.