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March 2021

Dr. Jialing Lin, COBRE Project Leader, has a new publication:

Zhang et al. (2021) "Cysteine-based crosslinking approach for characterization of oligomeric pore-forming proteins in the mitochondrial membrane", Methods Enzymol.  doi.org/10.1016/bs.mie.2021.01.023

Dr. Len Thomas, Facility Director of the COBRE Biomolecular Structure Core has a new publication:

Karsten et al. (2021) "Kinetic, spectral, and structural studies of the slow-binding inhibition of the Escherichia coli dihydrodipicolinate synthase by 2, 4-oxo-pentanoic acid", Arch. Biochem. Biophys.  doi.org/10.1016/j.abb.2021.108819

Dr. Robert Matts, former COBRE Project Leader, has a new publication:

Mishra et al. (2021) "Selective inhibition of the Hsp90a isoform", Angew Chem Intl Ed Eng.  doi: 10.1002/anie.202015422

February 2021

Dr. Christina Bourne, former COBRE Project Leader, has a new publication:

McGillick et al. (2021) "A YoeB toxin cleaves both RNA and DNA", Sci Rep. doi: 10.1038/s41598-021-82950-6

Dr. Marie Hanigan, former COBRE Project Leader, has a new publication:

Terzyan et al. (2021) "Crystal structures of glutathione- and inhibitor-bound human GGT1: Critical interactions within the cysteinylglycine binding site", J. Biol. Chem. doi: 10.1074/jbc.RA120.016265  

Dr. Blaine Mooers, Academic Core Director of the COBRE Biomolecular Structure Core, has two new publications:

Mooers and Brown (2021) "Templates for writing PyMOL scripts", Protein Sci. doi.org/10.1002/pro.3997

Subbiah et al. (2021) "Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations", Annals Oncol. doi.org/10.1016/j.annonc.2020.10.599

August 2020

Dr. Wei-Qun Ding, former COBRE Project Leader, has a new publication:

Xu et al. (2020) "SRSF1 regulates exosome microRNA enrichment in human cancer cells", Cell Communication and Signaling. doi: 10.1186/s12964-020-00615-9  

Dr. Rakhi Rajan, former COBRE Project Leader, has a new publication:

Van Orden et al. (2020) "CRISPR type II-A subgroups exhibit phylogenetically distinct mechanisms for spacer insertion", J. Biol. Chem. doi: 10.1074/jbc.RA120.013554  

May 2020

Dr. Anne Kasus-Jacobi, former COBRE Project Leader, has a new publication:

Kasus-Jacobi et al. (2020) "Antimicrobial peptides derived from the immune defense protein CAP37 inhibit TLR4 activation by S100A9", Invest. Ophthalmol. Vis. Sci., doi: 10.1167/iovs.61.4.16

Dr. Wei-Qun Ding, COBRE Project Leader, has a new publication:

Xu et al. (2020) "The role of exosomal microRNAs in pancreatic cancer", Stem Cell Investig., doi: 10.21037/sci.2020.02.01   

Dr. Christina Bourne, former COBRE Project Leader, has two new publications:

Ames et al. (2020) "Identifying a molecular mechanism that imparts species-specific toxicity to YoeB toxins", Front. Microbiol. doi: 10.3389/fmicb.2020.00959  

Muddala et al. (2020) "Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase", Eur. J. Med. Chem. doi.org/10.1016/j.ejmech.2020.112412

March 2020

Dr. Shanteri Singh, COBRE Project Leader, has a new publication:

Johnson et al. (2020) "Acceptor substrate determines the donor substrate specificity of an aromatic prenyltransferase: expanding the biocatalytic potential of NphB", Appl. Microbiol. Biotechnol., doi: 10.1007/s00253-020-10529-8     

Dr. Adam Duerfeldt, COBRE Project Leader, has a new publication:

Dou et al. (2020) "Structure-based evolution of a 4-benzyloxy-benzylamino chemotype to provide efficacious, potent, and isoform selective PPARα agonists as leads for retinal disorders",  J. Med. Chem. doi.org/10.1021/acs.jmedchem.9b01189    

February 2020

Dr. Indrajeet Sharma, fomer COBRE Project Leader, has a new publication:

Schlitzer et al. (2020) "A metal-free aromatic cascade for the synthesis of diverse heterocycles", Org. Chem. Front. doi: 10.1039/C9QO01336A        

January 2020

Dr. Augen Pioszak, former COBRE Project Leader, has a new publication:

Lee et al. (2020) "Calcitonin receptor N-glycosylation enhances peptide hormone affinity by controlling receptor dynamics", J. Mol. Biol.  doi.org/10.1016/j.jmb.2020.01.028      

Dr. Jialing Lin, COBRE Project Leader, has a new publication:

Chi et al. (2020) "The carboxyl-terminal sequence of Bim enables Bax activation and killing of unprimed cells", eLife.  doi.org/10.7554/eLife.44525     

December 2019

Dr. Yihan Shao, former COBRE Pilot Project Leader, has a new publication:

Tao et al. (2019) "Constructing spin-adiabatic states for the modeling of spin-crossing reactions. I. A shared-orbital implementation", Int. J. Quantum Chem. doi.org/10.1002/qua.26123     

Dr. Rakhi Rajan, COBRE Project Leader, has a new publication:

Chan et al. (2019) "Crystal structures of an unmodified bacterial tRNA reveal intrinsic structural flexibility and plasticity as general properties of folded tRNAs", RNA, doi:10.1261/rna.073478.119     

November 2019

Dr. Blaine Mooers, Academic Core Director of the COBRE Biomolecular Structure Core, has a new publication:

B.H.M. Mooers (2019) "Shortcuts for faster image creation in PyMOL", Protein Science, doi: 10.1002/pro.3781

October 2019

Dr. Ann West, COBRE PI, has a new publication:

Branscum, K.M., Menon, S.K., Foster, C.A., and West, A.H. (2019) "Insights revealed by the co-crystal structure of the Saccharomyces cerevisiae histidine phosphotransfer protein Ypd1 and the receiver domain of its downstream response regulator Ssk1", Protein Science, doi: 10.1002/pro.3755

Dr. Yihan Shao, COBRE Pilot Project Investigator, has been awarded a four-year R01 grant by the National Institutes of Health:

Project title: "Multiscale modeling of enzymatic reactions and firefly bioluminescence".